People

Professor Glyn Stanway

Emeritus Professor
School of Life Sciences
Professor Glyn Stanway

Profile

Biography

I joined the University 1986 as Lecturer in Molecular Genetics, after having done post-doctoral work in the Department of Medical Oncology, Charing Cross Hospital and the Department of Microbiology, University of Leicester. My PhD was done in the Chemistry Department, University College London. I take part in the activities of the European Study Group on the Molecular Biology of Picornaviruses, which organises the EUROPIC meetings. I am also a member of the ICTV Picornaviridae Study Group which reports on classification of picornaviruses. My research interests are centred on the molecular biology of medically important viruses. These include the enteroviruses which are a large group of RNA viruses and part of the Picornaviridae family. Important enteroviruses include the poliviruses, the causative agents of paralytic poliomyelitis, and coxsackieviruses which can cause a number of human diseases, including aseptic meningitis and heart disease. There is evidence that some enteroviruses can be the trigger for type 1 diabetes. My research interests also include the parechoviruses, which are increasingly being identified as important human pathogens of young children. All the work done in my laboratory is concerned with improving our understanding of how viruses replicate and cause disease and is intended to provide insights which may facilitate the design of effective vaccines or antivirus agents, as well as developing viruses as potential anti-cancer agents. We also have an active interest in virus taxonomy since understanding the relationship between viruses is important in identifying critical features which are central to replication.

Research and professional activities

Research interests

molecular virology of medically important picornaviruses, particularly coxsackievirus A9, parechoviruses and rhinoviruses

virus cell receptor interactions

RNA structures involved in replication

parechovirus and enterovirus molecular biology

Picornaviridae evolution and classification

translation and processing in picornaviruses

cell biology of virus infection

virotherapy of cancer

antivirus drugs

Teaching and supervision

Previous supervision

Osamah Abdullah Hasan Hasan
Osamah Abdullah Hasan Hasan
Thesis title: Pharmacology of Novel Approaches Designed to Target Picornaviral Infections
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 5/7/2021
Marina Ioannou
Marina Ioannou
Thesis title: Cell Surface Interactions of Coxsackie A9 Virus
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 29/6/2018
Ali Aidarous S Khrid
Ali Aidarous S Khrid
Thesis title: Analysis of the Interaction Between the 2C Protein of Parechoviruses and Lipid Droplets
Degree subject: Biological Sciences
Degree type: Doctor of Philosophy
Awarded date: 11/5/2017
Bandar Saleh S Aljuaid
Bandar Saleh S Aljuaid
Thesis title: Identification and Analysis of Arabidopsis Thiamine Pyrophosphate Transporters
Degree subject: Biological Sciences
Degree type: Doctor of Philosophy
Awarded date: 5/4/2017
Cheryl Kokomma Eno-Ibanga
Cheryl Kokomma Eno-Ibanga
Thesis title: The Analysis of a Conserved Rna Structure in the 3D Polymerase Encoding Region of Human Parechovirus 1
Degree subject: Microbiology
Degree type: Doctor of Philosophy
Awarded date: 15/2/2017
Ashjan Ali H Shami
Ashjan Ali H Shami
Thesis title: The Effect of Coxsackie Virus A9 Infection on Nuclear and Nucleolar Proteins
Degree subject: Biological Sciences
Degree type: Doctor of Philosophy
Awarded date: 22/9/2016
Waleed Ibrahim A Alabdulmenaim
Waleed Ibrahim A Alabdulmenaim
Thesis title: Regulation of Cd74 Expression in Response to Human Interferon Gamma and Lipopolysaccharide on Human Trophoblast Derived Cells: Relevance for Human Feto-Maternal Tolerance
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 19/8/2016
Osamah Mohammad A Al Rugaie
Osamah Mohammad A Al Rugaie
Thesis title: Presence and Role Acanthamoeba in Wound Infections
Degree subject: Molecular Medicine: Medical Microbiology
Degree type: Doctor of Philosophy
Awarded date: 6/7/2016
Wael Abdulghani A Obaid
Wael Abdulghani A Obaid
Thesis title: The Impact of Silver Nanoparticles on Plant Physiology
Degree subject: Biological Sciences
Degree type: Doctor of Philosophy
Awarded date: 24/5/2016
Hussain Mohammed M Al Ssadh
Hussain Mohammed M Al Ssadh
Thesis title: The Role of Immunological Receptors Cd74 and Cd44 in Association with the Macrophage Migration Inhibitory Factor (Mif) on Human Breast Cancer Derived Cells
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 7/3/2016
Naseebh Nabih A Baeshen
Naseebh Nabih A Baeshen
Thesis title: Molecular Basis of Adaptation of Enteroviruses to Different Cancer Cell Lines
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 22/12/2015
Arsalan Salimi
Arsalan Salimi
Thesis title: Investigation of the Localization and Role in Replication of the Parechovirus Non-Structural Proteins
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 14/1/2015
Shaia Saleh R Almalki
Shaia Saleh R Almalki
Thesis title: Understanding Parechovirus Pathogenesis Through Investigating Ires and Cell Receptor Tropism
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 24/4/2014
Almonther Abdullah Hershan
Almonther Abdullah Hershan
Thesis title: Identification and Analysis of Conserved Structures in Rna Viruses
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 6/7/2012

Publications

Journal articles (11)

Ioannou, M. and Stanway, G., (2021). Tropism of Coxsackie virus A9 depends on the +1 position of the RGD (arginine- glycine- aspartic acid) motif found at the C’ terminus of its VP1 capsid protein. Virus Research. 294, 198292-198292

Al-Zuhair, S., Ashraf, S., Hisaindee, S., Darmaki, NA., Battah, S., Svistunenko, D., Reeder, BJ., Stanway, G. and Chaudhary, A., (2017). Enzymatic pre-treatment of microalgae cells for enhanced extraction of proteins. Engineering in Life Sciences. 17 (2), 175-185

Oikarinen, S., Tauriainen, S., Hober, D., Lucas, B., Vazeou, A., Sioofy-Khojine, A., Bozas, E., Muir, P., Honkanen, H., Ilonen, J., Knip, M., Keskinen, P., Saha, M., Huhtala, H., Stanway, G., Bartsocas, C., Ludvigsson, J., Taylor, K. and Hyoty, H., (2014). Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes. Diabetes. 63 (2), 655-662

McLeish, NJ., Williams, CH., Kaloudas, D., Roivainen, MM. and Stanway, G., (2012). Symmetry-related clustering of positive charges is a common mechanism for heparan sulfate binding in enteroviruses.. Journal of virology. 86 (20), 11163-70

Benschop, KSM., de Vries, M., Minnaar, RP., Stanway, G., van der Hoek, L., Wolthers, KC. and Simmonds, P., (2010). Comprehensive full-length sequence analyses of human parechoviruses: diversity and recombination. Journal of General Virology. 91 (Part 1), 145-154

Stanway, G. and Williams, CH., (2009). Enteroviruses and Diabetes. Journal of Medical Virology. 81 (1), creators-Stanway=3AGlyn=3A=3A

Williams, CH., Panayiotou, M., Girling, GD., Peard, CI., Oikarinen, S., Hyoty, H. and Stanway, G., (2009). Evolution and conservation in human parechovirus genomes. Journal of General Virology. 90 (7), 1702-1712

Heikkila, O., Susi, P., Stanway, G. and Hyypia, T., (2009). Integrin alpha V beta 6 is a high-affinity receptor for coxsackievirus A9. Journal of General Virology. 90 (1), 197-204

Williams, CH. and Stanway, G., (2009). Viruses: Genomes and Genomics. eLS

Le Gall, O., Christian, P., Fauquet, CM., King, AMQ., Knowles, NJ., Nakashima, N., Stanway, G. and Gorbalenya, AE., (2008). Picornavirales, a proposed order of positive-sense single-stranded RNA viruses with a pseudo-T=3 virion architecture. Archives Of Virology. 153 (4), 715-727

Benschop, KSM., Williams, CH., Wolthers, KC., Stanway, G. and Simmonds, P., (2008). Widespread recombination within human parechoviruses: analysis of temporal dynamics and constraints. Journal of General Virology. 89 (Part 4), 1030-1035

Contact

stanwg@essex.ac.uk

Location:

Colchester Campus