Dr Graham Mitchell

-
Email
gmitch@essex.ac.uk -
Telephone
+44 (0) 1206 876002
-
Location
3SW.4.09, Colchester Campus
Teaching and supervision
Previous supervision

Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 16/8/2017

Degree subject: Molecular Medicine: Medical Microbiology
Degree type: Doctor of Philosophy
Awarded date: 5/1/2017
Publications
Journal articles (77)
Mitchell, GH. and Butcher, GA., (2018). The role of Plasmodium knowlesi in the history of malaria research. Parasitology. 145 (1), 6-17
Moon, RW., Hall, J., Rangkuti, F., Ho, YS., Almond, N., Mitchell, GH., Pain, A., Holder, AA. and Blackman, MJ., (2013). Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes.. Proceedings of the National Academy of Sciences of the United States of America. 110 (2), 531-536
Vermeer, LS., Lan, Y., Abbate, V., Ruh, E., Bui, TT., Wilkinson, LJ., Kanno, T., Jumagulova, E., Kozlowska, J., Patel, J., McIntyre, CA., Yam, WC., Siu, G., Atkinson, RA., Lam, JKW., Bansal, SS., Drake, AF., Mitchell, GH. and Mason, AJ., (2012). Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic a-helical peptides.. The Journal of Biological Chemistry. 287 (41), 34120-34133
Butcher, GA., Mitchell, GH. and Cohen, S., (2010). Plasmodium knowlesi infections in a small number of non-immune natural hosts (Macaca fascicularis) and in rhesus monkeys (M. mulatta).. Transactions of the Royal Society of Tropical Medicine and Hygiene. 104 (1), 75-77
BANNISTER, LH. and MITCHELL, GH., (2009). The malaria merozoite, forty years on. Parasitology. 136 (12), 1435-1444
JACKSON, S., MOLDOVEANU, Z., KIRK, KA., JULIAN, BA., PATTERSON, TF., MULLINS, AL., JILLING, T., MESTECKY, J. and GALLA, JH., (2008). IgA-containing immune complexes after challenge with food antigens in patients with IgA nephropathy. Clinical and Experimental Immunology. 89 (2), 315-320
Dluzewski, AR., Ling, IT., Hopkins, JM., Grainger, M., Margos, G., Mitchell, GH., Holder, AA. and Bannister, LH., (2008). Formation of the Food Vacuole in Plasmodium falciparum: A Potential Role for the 19 kDa Fragment of Merozoite Surface Protein 1 (MSP119). PLoS ONE. 3 (8), e3085-e3085
Yeoh, S., O'Donnell, RA., Koussis, K., Dluzewski, AR., Ansell, KH., Osborne, SA., Hackett, F., Withers-Martinez, C., Mitchell, GH., Bannister, LH., Bryans, JS., Kettleborough, CA. and Blackman, MJ., (2007). Subcellular Discharge of a Serine Protease Mediates Release of Invasive Malaria Parasites from Host Erythrocytes. Cell. 131 (6), 1072-1083
Pachebat, JA., Kadekoppala, M., Grainger, M., Dluzewski, AR., Gunaratne, RS., Scott-Finnigan, TJ., Ogun, SA., Ling, IT., Bannister, LH., Taylor, HM., Mitchell, GH. and Holder, AA., (2007). Extensive proteolytic processing of the malaria parasite merozoite surface protein 7 during biosynthesis and parasite release from erythrocytes. Molecular and Biochemical Parasitology. 151 (1), 59-69
Harris, PK., Yeoh, S., Dluzewski, AR., O'Donnell, RA., Withers-Martinez, C., Hackett, F., Bannister, LH., Mitchell, GH. and Blackman, MJ., (2005). Molecular Identification of a Malaria Merozoite Surface Sheddase. PLoS Pathogens. 1 (3), e29-e29
Chaparro‐Olaya, J., Margos, G., Coles, DJ., Dluzewski, AR., Mitchell, GH., Wasserman, MM. and Pinder, JC., (2005). Plasmodium falciparum myosins: Transcription and translation during asexual parasite development. Cell Motility. 60 (4), 200-213
Bannister, LH., Hopkins, JM., Margos, G., Dluzewski, AR. and Mitchell, GH., (2004). Three-Dimensional Ultrastructure of the Ring Stage ofPlasmodium falciparum: Evidence for Export Pathways. Microscopy and Microanalysis. 10 (5), 551-562
Mitchell, GH., Thomas, AW., Margos, G., Dluzewski, AR. and Bannister, LH., (2004). Apical Membrane Antigen 1, a Major Malaria Vaccine Candidate, Mediates the Close Attachment of Invasive Merozoites to Host Red Blood Cells. Infection and Immunity. 72 (1), 154-158
MARGOS, G., BANNISTER, LH., DLUZEWSKI, AR., HOPKINS, J., WILLIAMS, IT. and MITCHELL, GH., (2004). Correlation of structural development and differential expression of invasion-related molecules in schizonts ofPlasmodium falciparum. Parasitology. 129 (3), 273-287
Bannister, LH., Hopkins, JM., Dluzewski, AR., Margos, G., Williams, IT., Blackman, MJ., Kocken, CH., Thomas, AW. and Mitchell, GH., (2003). Plasmodium falciparumapical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development. Journal of Cell Science. 116 (18), 3825-3834
Bannister, L. and Mitchell, G., (2003). The ins, outs and roundabouts of malaria. Trends in Parasitology. 19 (5), 209-213
Fowler, RE., Smith, AMC., Whitehorn, J., Williams, IT., Bannister, LH. and Mitchell, GH., (2001). Microtubule associated motor proteins of Plasmodium falciparum merozoites. Molecular and Biochemical Parasitology. 117 (2), 187-200
Bannister, LH., Hopkins, JM., Fowler, RE., Krishna, S. and Mitchell, GH., (2000). A Brief Illustrated Guide to the Ultrastructure of Plasmodium falciparum Asexual Blood Stages. Parasitology Today. 16 (10), 427-433
BANNISTER, LH., HOPKINS, JM., FOWLER, RE., KRISHNA, S. and MITCHELL, GH., (2000). Ultrastructure of rhoptry development in Plasmodium falciparum erythrocytic schizonts. Parasitology. 121 (3), 273-287
Pinder, J., Fowler, R., Bannister, L., Dluzewski, A. and Mitchell, G., (2000). Motile Systems in Malaria Merozoites: How is the Red Blood Cell Invaded?. Parasitology Today. 16 (6), 240-245
Margos, G., Sidén-Kiamos, I., Fowler, RE., Gillman, TR., Spaccapelo, R., Lycett, G., Vlachou, D., Papagiannakis, G., Eling, WM., Mitchell, GH. and Louis, C., (2000). Myosin-A expressions in sporogonic stages of Plasmodium. Molecular and Biochemical Parasitology. 111 (2), 465-469
Hopkins, J., Fowler, R., Krishna, S., Wilson, I., Mitchell, G. and Bannister, L., (1999). The Plastid in Plasmodium falciparum Asexual Blood Stages: a Three-Dimensional Ultrastructural Analysis. Protist. 150 (3), 283-295
Pinder, JC., Fowler, RE., Dluzewski, AR., Bannister, LH., Lavin, FM., Mitchell, GH., Wilson, RJM. and Gratzer, WB., (1998). Actomyosin motor in the merozoite of the malaria parasite, Plasmodium falciparum: implications for red cell invasion. Journal of Cell Science. 111 (13), 1831-1839
FOWLER, RE., FOOKES, RE., LAVIN, F., BANNISTER, LH. and MITCHELL, GH., (1998). Microtubules in Plasmodium falciparum merozoites and their importance for invasion of erythrocytes. Parasitology. 117 (5), 425-433
BEJON, PA., BANNISTER, LH., FOWLER, RE., FOOKES, RE., WEBB, SE., WRIGHT, A. and MITCHELL, GH., (1997). A role for microtubules in Plasmodium falciparum merozoite invasion. Parasitology. 114 (1), 1-6
Webb, SE., Fowler, RE., O'Shaughnessy, C., Pinder, JC., Dluzewski, AR., Gratzer, WB., Bannister, LH. and Mitchell, GH., (1996). Contractile protein system in the asexual stages of the malaria parasite Plasmodium falciparum. Parasitology. 112 (5), 451-457
Bannister, LH. and Mitchell, GH., (1995). The role of the cytoskeleton inPlasmodium falciparummerozoite biology: an electron-microscopic view. Annals of Tropical Medicine & Parasitology. 89 (2), 105-111
Thomas, AW., Narum, D., Waters, AP., Trape, JF., Rogier, C., Gonçalves, A., Rosario, V., Druilhe, P., Mitchell, GH. and Dennis, D., (1994). Aspects of immunity for the AMA-1 family of molecules in humans and non-human primates malarias. Memórias do Instituto Oswaldo Cruz. 89 (suppl 2), 67-70
Goodier, M., Krause-Jauer, M., Sanni, A., Massougbodji, A., Sadeler, B-C., Mitchell, GH., Modolell, M., Eichmann, K. and Langhorne, J., (1993). γδ T cells in the peripheral blood of individuals from an area of holoendemic Plasmodium falciparum transmission. Transactions of the Royal Society of Tropical Medicine and Hygiene. 87 (6), 692-696
Dluzewski, AR., Mitchell, GH., Fryer, PR., Griffiths, S., Wilson, RJM. and Gratzer, WB., (1992). Origins of the parasitophorous vacuole membrane of the malaria parasite, Plasmodium falciparum, in human red blood cells. Journal of Cell Science. 102 (3), 527-532
WATERS, A., THOMAS, A., MITCHELL, G. and MCCUTCHAN, T., (1991). Intra-generic conservation and limited inter-strain variation in a protective minor surface antigen of Plasmodium knowlesi merozoites. Molecular and Biochemical Parasitology. 44 (1), 141-144
Mitchell, GH., (1991). Malaria research in Colombia: has a useful malaria vaccine arrived?. Vaccine. 9 (4), 219-219
Johnston, DA., Knight, AM., Naylor, BA., Wedderburn, N. and Mitchell, GH., (1990). Monoclonal antibodies from Epstein-Barr virus-transformed lymphocytes of common marmosets (Callithrix jacchus) immune to malaria. Journal of Immunological Methods. 127 (2), 187-195
Waters, AP., Thomas, AW., Deans, JA., Mitchell, GH., Hudson, DE., Miller, LH., McCutchan, TF. and Cohen, S., (1990). A merozoite receptor protein from Plasmodium knowlesi is highly conserved and distributed throughout Plasmodium.. Journal of Biological Chemistry. 265 (29), 17974-17979
Mitchell, GH., (1990). Progress toward malaria vaccination. Current Opinion in Infectious Diseases. 3 (3), 387-392
Mitchell, GH., (1989). Immunization against parasitic disease. Current Opinion in Infectious Diseases. 2 (6), 765-772
Mitchell, GH., (1989). An update on candidate malaria vaccines. Parasitology. 98 (S1), S29-S47
BANNISTER, LH. and MITCHELL, GH., (1989). The Fine Structure of Secretion by Plasmodium knowlesi Merozoites during Red Cell Invasion. The Journal of Protozoology. 36 (4), 362-367
Mitchell, GH., (1989). A vaccine for ovine cysticercosis. Vaccine. 7 (5), 379-379
Mitchell, GH., (1988). Immunization against protozoan disease. Current Opinion in Infectious Diseases. 1 (6), 883-889
Mitchell, GH., Bannister, LH. and Sinden, RE., (1988). Malaria parasite invasion: Interactions with the red cell membrane. Critical Reviews in Oncology/Hematology. 8 (4), 255-310
DEANS, JA., KNIGHT, AM., JEAN, WC., WATERS, AP., COHEN, S. and MITCHELL, GH., (1988). Vaccination trials in rhesus monkeys with a minor, invariant, Plasmodium knowlesi 66 kD merozoite antigen. Parasite Immunology. 10 (5), 535-552
Wedderburn, N., Davies, DR., Mitchell, GH., Desgranges, C. and de The, G., (1988). Glomerulonephritis in Common Marmosets Infected with Plasmodium brasilianum and Epstein-Barr Virus. Journal of Infectious Diseases. 158 (4), 789-794
Mitchell, GH., Johnston, DA., Naylor, BA., Knight, AM. and Wedderburn, N., (1988). Plasmodium vivax malaria in the common marmoset, Callithrix jacchus: adaptation and host response to infection. Parasitology. 96 (2), 241-250
Mitchell, GH., (1987). The comparative immunobiology of Plasmodium: model systems and new technologies in malaria vaccine research.. Progress in veterinary microbiology and immunology. 3, 112-138
Bannister, LH., Mitchell, GH., Butcher, GA. and Dennis, ED., (1986). Lamellar membranes associated with rhoptries in erythrocytic merozoites ofPlasmodium knowlesi: a clue to the mechanism of invasion. Parasitology. 92 (2), 291-303
BANNISTER, LH. and MITCHELL, GH., (1986). Lipidic Vacuoles in Plasmodium knowlesi Erythrocytic Schizonts. The Journal of Protozoology. 33 (2), 271-275
Bannister, LH., Mitchell, GH., Butcher, GA., Dennis, ED. and Cohen, S., (1986). Structure and development of the surface coat of erythrocytic merozoites of Plasmodium knowlesi. Cell and Tissue Research. 245 (2), 281-290
Mitchell, GH., Hadley, TJ., McGinniss, MH., Klotz, FW. and Miller, LH., (1986). Invasion of erythrocytes by Plasmodium falciparum malaria parasites: evidence for receptor heterogeneity and two receptors. Blood. 67 (5), 1519-1521
Sharma, S., Svec, P., Mitchell, GH. and Godson, GN., (1985). Diversity of circumsporozoite antigen genes from two different strains of the malarial parasite Plasmodium knowlesi. Federation Proceedings. 44 (3)
Sharma, S., Svec, P., Mitchell, GH. and Godson, GN., (1985). Diversity of Circumsporozoite Antigen Genes from Two Strains of the Malarial Parasite Plasmodium knowlesi. Science. 229 (4715), 779-782
Wedderburn, N., Mitchell, GH. and Davies, DR., (1985). Plasmodium brasilianum in the common marmoset Callithrix jacchus. Parasitology. 90 (3), 573-578
Thomas, AW., Deans, JA., Mitchell, GH., Alderson, T. and Cohen, S., (1984). The Fab fragments of monoclonal IgG to a merozoite surface antigen inhibit Plasmodium knowlesi invasion of erythrocytes. Molecular and Biochemical Parasitology. 13 (2), 187-199
Mitchell, GH., (1984). Vaccination against malaria: its plausibility and the present state of research. Vaccine. 2 (2), 115-124
Facer, CA. and Mitchell, GH., (1984). Wrb NEGATIVE ERYTHROCYTES ARE SUSCEPTIBLE TO INVASION BY MALARIA PARASITES. The Lancet. 324 (8405), 758-759
Deans, JA., Alderson, T., Thomas, AW., Mitchell, GH., Lennox, ES. and Cohen, S., (1982). Rat monoclonal antibodies which inhibit the in vitro multiplication of Plasmodium knowlesi. Clinical and Experimental Immunology. 49 (2), 297-309
Mitchell, GH., Cohen, S., Black, CDV., Voller, A., Dietrich, FM. and Dukor, P., (1981). Novel adjuvants in malaria vaccination. Transactions of the Royal Society of Tropical Medicine and Hygiene. 75 (1), 187-188
Wickham, JM., Dennis, ED. and Mitchell, GH., (1980). Long term cultivation of a simian malaria parasite (Plasmodium knowlesi) in a semi-automated apparatus. Transactions of the Royal Society of Tropical Medicine and Hygiene. 74 (6), 789-792
Mitchell, GH., Richards, WHG., Voller, A., Dietrich, FM. and Dukor, P., (1979). Nor-MDP, saponin, corynebacteria, and pertussis organisms as immunological adjuvants in experimental malaria vaccination of macaques. Bulletin of the World Health Organization. 57 (Suppl. 1), 189-197
Cohen, S. and Mitchell, GH., (1978). Prospects for Immunisation Against Malaria. Current Topics in Microbiology and Immunology. 80, 97-137
Butcher, GA., Mitchell, GH. and Cohen, S., (1978). Antibody mediated mechanisms of immunity to malaria induced by vaccination with Plasmodium knowlesi merozoites. Immunology. 34 (1), 77-86
Richards, WHG., Mitchell, GH., Butcher, GA. and Cohen, S., (1977). Merozoite vaccination of rhesus monkeys against plasmodium knowlesi malaria; immunity to sporozoite (mosquito-transmitted) challenge. Parasitology. 74 (2), 191-198
Cohen, S., Butcher, GA. and Mitchell, GH., (1977). Immunization Against Erythrocytic Forms of Malaria Parasites. Advances in experimental medicine and biology. 93, 89-112
Mitchell, GH., Butcher, GA., Richards, WHG. and Cohen, S., (1977). MEROZOITE VACCINATION OF DOUROUCOULI MONKEYS AGAINST FALCIPARUM MALARIA. The Lancet. 309 (8026), 1335-1338
Bannister, LH., Butcher, GA. and Mitchell, GH., (1977). Recent advances in understanding the invasion of erythrocytes by merozoites of Plasmodium knowlesi. Bulletin of the World Health Organization. 55 (2-3), 163-169
Cohen, S., Butcher, GA., Mitchell, GH., Deans, JA. and Langhorne, J., (1977). Acquired Immunity and Vaccination in Malaria. The American Journal of Tropical Medicine and Hygiene. 26 (6_Part_2), 223-232
Mitchell, GH., Butcher, GA., Langhorne, J. and Cohen, S., (1977). A freeze dried merozoite vaccine effective against Plasmodium knowlesi malaria. Clinical and Experimental Immunology. 28 (1), 276-279
Mitchell, GH., (1977). A review of merozoite vaccination against Plasmodium knowlesi malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. 71 (4), 281-282
Mitchell, GH., Butcher, GA., Voller, A. and Cohen, S., (1976). The effect of human immune IgG on the in vitro development of Plasmodium falciparum. Parasitology. 72 (2), 149-162
Bannister, LH., Butcher, GA., Dennis, ED. and Mitchell, GH., (1975). Studies on the structure and invasive behaviour of merozoites of Plasmodium knowlesi.. Transactions of the Royal Society of Tropical Medicine and Hygiene. 69 (1), 5-
Bannister, LH., Butcher, GA., Dennis, ED. and Mitchell, GH., (1975). Structure and invasive behaviour ofPlasmodium knowlesimerozoitesin vitro. Parasitology. 71 (3), 483-491
Dennis, ED., Mitchell, GH., Butcher, GA. and Cohen, S., (1975). In vitroisolation ofPlasmodium knowlesimerozoites using polycarbonate sieves. Parasitology. 71 (3), 475-481
Mitchell, GH., Butcher, GA. and Cohen, S., (1975). Merozoite vaccination against Plasmodium knowlesi malaria. Immunological Communications. 29 (2), 397-407
Cohen, S., Butcher, GA. and Mitchell, GH., (1974). Mechanisms of immunity to malaria. Bulletin of the World Health Organization. 50 (3-4), 251-257
MITCHELL, GH., BUTCHER, GA. and COHEN, S., (1974). A merozoite vaccine effective against Plasmodium knowlesi malaria. Nature. 252 (5481), 311-313
Mitchell, GH., Butcher, GA. and Cohen, S., (1973). Isolation of blood-stage merozoites from Plasmodium knowlesi malaria. International Journal for Parasitology. 3 (3), 443-445
BUTCHER, GA., MITCHELL, GH. and COHEN, S., (1973). Mechanism of Host Specificity in Malarial Infection. Nature. 244 (5410), 40-42
Books (1)
FOWLER, R., MARGOS, G. and MITCHELL, G., (2003). The Cytoskeleton and Motility in Apicomplexan Invasion. Elsevier. 9780120317561
Conferences (1)
Chaparro-Olaya, J., Dluzewski, AR., Margos, G., Wasserman, MM., Mitchell, GH., Bannister, LH. and Pinder, JC., (2003). The multiple myosins of malaria: The smallest malaria myosin, Plasmodium falciparum myosin-B (Pfmyo-B) is expressed in mature schizonts and merozoites
Other (1)
Dobson, A., (2001).Invertebrates are here again. Trends in Parasitology. 17(12),Elsevier BV