2020 applicants
People

Dr Graham Mitchell

Visiting Professor
School of Life Sciences
Dr Graham Mitchell
  • Email

  • Telephone

    +44 (0) 1206 876002

  • Location

    3SW.4.09, Colchester Campus

Teaching and supervision

Current teaching responsibilities

  • Medical Microbiology (BS235)

Previous supervision

Aiden Matthew Jayanth
Aiden Matthew Jayanth
Thesis title: Experimental Studies on the Microbiota Associated with Urinary Tract Infections
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 16/8/2017
Bauyrzhan Tashmukhambetov
Bauyrzhan Tashmukhambetov
Thesis title: An Investigation of the Effects of an Antimicrobial Peptide on the Survival of Acanthamoeba and Intracellular Bacteria Associated with Cystic Fibrosis
Degree subject: Molecular Medicine: Medical Microbiology
Degree type: Doctor of Philosophy
Awarded date: 5/1/2017

Publications

Journal articles (77)

Mitchell, GH. and Butcher, GA., (2018). The role of Plasmodium knowlesi in the history of malaria research. Parasitology. 145 (1), 6-17

Moon, RW., Hall, J., Rangkuti, F., Ho, YS., Almond, N., Mitchell, GH., Pain, A., Holder, AA. and Blackman, MJ., (2013). Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes.. Proceedings of the National Academy of Sciences of the United States of America. 110 (2), 531-536

Vermeer, LS., Lan, Y., Abbate, V., Ruh, E., Bui, TT., Wilkinson, LJ., Kanno, T., Jumagulova, E., Kozlowska, J., Patel, J., McIntyre, CA., Yam, WC., Siu, G., Atkinson, RA., Lam, JKW., Bansal, SS., Drake, AF., Mitchell, GH. and Mason, AJ., (2012). Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic a-helical peptides.. The Journal of Biological Chemistry. 287 (41), 34120-34133

Butcher, GA., Mitchell, GH. and Cohen, S., (2010). Plasmodium knowlesi infections in a small number of non-immune natural hosts (Macaca fascicularis) and in rhesus monkeys (M. mulatta).. Transactions of the Royal Society of Tropical Medicine and Hygiene. 104 (1), 75-77

BANNISTER, LH. and MITCHELL, GH., (2009). The malaria merozoite, forty years on. Parasitology. 136 (12), 1435-1444

Dluzewski, AR., Ling, IT., Hopkins, JM., Grainger, M., Margos, G., Mitchell, GH., Holder, AA. and Bannister, LH., (2008). Formation of the Food Vacuole in Plasmodium falciparum: A Potential Role for the 19 kDa Fragment of Merozoite Surface Protein 1 (MSP119). PLoS ONE. 3 (8), e3085-e3085

Yeoh, S., O'Donnell, RA., Koussis, K., Dluzewski, AR., Ansell, KH., Osborne, SA., Hackett, F., Withers-Martinez, C., Mitchell, GH., Bannister, LH., Bryans, JS., Kettleborough, CA. and Blackman, MJ., (2007). Subcellular Discharge of a Serine Protease Mediates Release of Invasive Malaria Parasites from Host Erythrocytes. Cell. 131 (6), 1072-1083

Pachebat, JA., Kadekoppala, M., Grainger, M., Dluzewski, AR., Gunaratne, RS., Scott-Finnigan, TJ., Ogun, SA., Ling, IT., Bannister, LH., Taylor, HM., Mitchell, GH. and Holder, AA., (2007). Extensive proteolytic processing of the malaria parasite merozoite surface protein 7 during biosynthesis and parasite release from erythrocytes. Molecular and Biochemical Parasitology. 151 (1), 59-69

Harris, PK., Yeoh, S., Dluzewski, AR., O'Donnell, RA., Withers-Martinez, C., Hackett, F., Bannister, LH., Mitchell, GH. and Blackman, MJ., (2005). Molecular Identification of a Malaria Merozoite Surface Sheddase. PLoS Pathogens. 1 (3), e29-e29

Chaparro-Olaya, J., Margos, G., Coles, DJ., Dluzewski, AR., Mitchell, GH., Wasserman, MM. and Pinder, JC., (2005). Plasmodium falciparummyosins: Transcription and translation during asexual parasite development. Cell Motility and the Cytoskeleton. 60 (4), 200-213

Bannister, LH., Hopkins, JM., Margos, G., Dluzewski, AR. and Mitchell, GH., (2004). Three-Dimensional Ultrastructure of the Ring Stage of Plasmodium falciparum: Evidence for Export Pathways. Microscopy and Microanalysis. 10 (5), 551-562

Mitchell, GH., Thomas, AW., Margos, G., Dluzewski, AR. and Bannister, LH., (2004). Apical Membrane Antigen 1, a Major Malaria Vaccine Candidate, Mediates the Close Attachment of Invasive Merozoites to Host Red Blood Cells. Infection and Immunity. 72 (1), 154-158

MARGOS, G., BANNISTER, LH., DLUZEWSKI, AR., HOPKINS, J., WILLIAMS, IT. and MITCHELL, GH., (2004). Correlation of structural development and differential expression of invasion-related molecules in schizonts ofPlasmodium falciparum. Parasitology. 129 (3), 273-287

Bannister, LH., (2003). Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development. Journal of Cell Science. 116 (18), 3825-3834

Bannister, L. and Mitchell, G., (2003). The ins, outs and roundabouts of malaria. Trends in Parasitology. 19 (5), 209-213

Fowler, RE., Smith, AMC., Whitehorn, J., Williams, IT., Bannister, LH. and Mitchell, GH., (2001). Microtubule associated motor proteins of Plasmodium falciparum merozoites. Molecular and Biochemical Parasitology. 117 (2), 187-200

Bannister, LH., Hopkins, JM., Fowler, RE., Krishna, S. and Mitchell, GH., (2000). A Brief Illustrated Guide to the Ultrastructure of Plasmodium falciparum Asexual Blood Stages. Parasitology Today. 16 (10), 427-433

BANNISTER, LH., HOPKINS, JM., FOWLER, RE., KRISHNA, S. and MITCHELL, GH., (2000). Ultrastructure of rhoptry development in Plasmodium falciparum erythrocytic schizonts. Parasitology. 121 (3), 273-287

Pinder, J., Fowler, R., Bannister, L., Dluzewski, A. and Mitchell, G., (2000). Motile Systems in Malaria Merozoites: How is the Red Blood Cell Invaded?. Parasitology Today. 16 (6), 240-245

Margos, G., Sidén-Kiamos, I., Fowler, RE., Gillman, TR., Spaccapelo, R., Lycett, G., Vlachou, D., Papagiannakis, G., Eling, WM., Mitchell, GH. and Louis, C., (2000). Myosin-A expressions in sporogonic stages of Plasmodium. Molecular and Biochemical Parasitology. 111 (2), 465-469

Hopkins, J., Fowler, R., Krishna, S., Wilson, I., Mitchell, G. and Bannister, L., (1999). The Plastid in Plasmodium falciparum Asexual Blood Stages: a Three-Dimensional Ultrastructural Analysis. Protist. 150 (3), 283-295

Pinder, JC., Fowler, RE., Dluzewski, AR., Bannister, LH., Lavin, FM., Mitchell, GH., Wilson, RJM. and Gratzer, WB., (1998). Actomyosin motor in the merozoite of the malaria parasite, Plasmodium falciparum: Implications for red cell invasion. Journal of Cell Science. 111 (13), 1831-1839

FOWLER, RE., FOOKES, RE., LAVIN, F., BANNISTER, LH. and MITCHELL, GH., (1998). Microtubules in Plasmodium falciparum merozoites and their importance for invasion of erythrocytes. Parasitology. 117 (5), 425-433

BEJON, PA., BANNISTER, LH., FOWLER, RE., FOOKES, RE., WEBB, SE., WRIGHT, A. and MITCHELL, GH., (1997). A role for microtubules in Plasmodium falciparum merozoite invasion. Parasitology. 114 (1), 1-6

Webb, SE., Fowler, RE., O'Shaughnessy, C., Pinder, JC., Dluzewski, AR., Gratzer, WB., Bannister, LH. and Mitchell, GH., (1996). Contractile protein system in the asexual stages of the malaria parasite Plasmodium falciparum. Parasitology. 112 (5), 451-457

Bannister, LH. and Mitchell, GH., (1995). The role of the cytoskeleton in Plasmodium falciparum merozoite biology: an electron-microscopic view. Annals of Tropical Medicine & Parasitology. 89 (2), 105-111

Thomas, AW., Narum, D., Waters, AP., Trape, JF., Rogier, C., Gonçalves, A., Rosario, V., Druilhe, P., Mitchell, GH. and Dennis, D., (1994). Aspects of immunity for the AMA-1 family of molecules in humans and non-human primates malarias. Memórias do Instituto Oswaldo Cruz. 89 (suppl 2), 67-70

Goodier, M., Krause-Jauer, M., Sanni, A., Massougbodji, A., Sadeler, B-C., Mitchell, GH., Modolell, M., Eichmann, K. and Langhorne, J., (1993). γδ T cells in the peripheral blood of individuals from an area of holoendemic Plasmodium falciparum transmission. Transactions of the Royal Society of Tropical Medicine and Hygiene. 87 (6), 692-696

Dluzewski, AR., Mitchell, GH., Fryer, PR., Griffiths, S., Wilson, RJM. and Gratzer, WB., (1992). Origins of the parasitophorous vacuole membrane of the malaria parasite, Plasmodium falciparum, in human red blood cells. Journal of Cell Science. 102 (3), 527-532

WATERS, A., THOMAS, A., MITCHELL, G. and MCCUTCHAN, T., (1991). Intra-generic conservation and limited inter-strain variation in a protective minor surface antigen of Plasmodium knowlesi merozoites. Molecular and Biochemical Parasitology. 44 (1), 141-144

Mitchell, GH., (1991). Malaria research in Colombia: has a useful malaria vaccine arrived?. Vaccine. 9 (4), 219-219

Johnston, DA., Knight, AM., Naylor, BA., Wedderburn, N. and Mitchell, GH., (1990). Monoclonal antibodies from Epstein-Barr virus-transformed lymphocytes of common marmosets (Callithrix jacchus) immune to malaria. Journal of Immunological Methods. 127 (2), 187-195

Waters, AP., Thomas, AW., Deans, JA., Mitchell, GH., Hudson, DE., Miller, LH., McCutchan, TF. and Cohen, S., (1990). A merozoite receptor protein from Plasmodium knowlesi is highly conserved and distributed throughout Plasmodium. Journal of Biological Chemistry. 265 (29), 17974-17979

Mitchell, GH., (1990). Progress toward malaria vaccination. Current Opinion in Infectious Diseases. 3 (3), 387-392

Mitchell, GH., (1989). Immunization against parasitic disease. Current Opinion in Infectious Diseases. 2 (6), 765-772

Mitchell, GH., (1989). An update on candidate malaria vaccines. Parasitology. 98 (S1), S29-S47

BANNISTER, LH. and MITCHELL, GH., (1989). The Fine Structure of Secretion by Plasmodium knowlesi Merozoites during Red Cell Invasion. The Journal of Protozoology. 36 (4), 362-367

Mitchell, GH., (1989). A vaccine for ovine cysticercosis. Vaccine. 7 (5), 379-379

Mitchell, GH., (1988). Immunization against protozoan disease. Current Opinion in Infectious Diseases. 1 (6), 883-889

Mitchell, GH., Bannister, LH. and Sinden, RE., (1988). Malaria parasite invasion: Interactions with the red cell membrane. Critical Reviews in Oncology/Hematology. 8 (4), 255-310

DEANS, JA., KNIGHT, AM., JEAN, WC., WATERS, AP., COHEN, S. and MITCHELL, GH., (1988). Vaccination trials in rhesus monkeys with a minor, invariant, Plasmodium knowlesi 66 kD merozoite antigen. Parasite Immunology. 10 (5), 535-552

Wedderburn, N., Davies, DR., Mitchell, GH., Desgranges, C. and de The, G., (1988). Glomerulonephritis in Common Marmosets Infected with Plasmodium brasilianum and Epstein-Barr Virus. Journal of Infectious Diseases. 158 (4), 789-794

Mitchell, GH., Johnston, DA., Naylor, BA., Knight, AM. and Wedderburn, N., (1988). Plasmodium vivax malaria in the common marmoset, Callithrix jacchus: adaptation and host response to infection. Parasitology. 96 (2), 241-250

Mitchell, GH., (1987). The comparative immunobiology of Plasmodium: model systems and new technologies in malaria vaccine research.. Progress in veterinary microbiology and immunology. 3, 112-138

Bannister, LH., Mitchell, GH., Butcher, GA. and Dennis, ED., (1986). Lamellar membranes associated with rhoptries in erythrocytic merozoites of Plasmodium knowlesi: a clue to the mechanism of invasion. Parasitology. 92 (2), 291-303

BANNISTER, LH. and MITCHELL, GH., (1986). Lipidic Vacuoles inPlasmodium knowlesiErythrocytic Schizonts. The Journal of Protozoology. 33 (2), 271-275

Bannister, LH., Mitchell, GH., Butcher, GA., Dennis, ED. and Cohen, S., (1986). Structure and development of the surface coat of erythrocytic merozoites of Plasmodium knowlesi. Cell and Tissue Research. 245 (2), 281-290

Mitchell, GH., Hadley, TJ., McGinniss, MH., Klotz, FW. and Miller, LH., (1986). Invasion of erythrocytes by Plasmodium falciparum malaria parasites: evidence for receptor heterogeneity and two receptors. Blood. 67 (5), 1519-1521

Sharma, S., Svec, P., Mitchell, GH. and Godson, GN., (1985). Diversity of circumsporozoite antigen genes from two different strains of the malarial parasite Plasmodium knowlesi. Federation Proceedings. 44 (3)

Sharma, S., Svec, P., Mitchell, G. and Godson, G., (1985). Diversity of circumsporozoite antigen genes from two strains of the malarial parasite Plasmodium knowlesi. Science. 229 (4715), 779-782

Wedderburn, N., Mitchell, GH. and Davies, DR., (1985). Plasmodium brasilianum in the common marmoset Callithrix jacchus. Parasitology. 90 (3), 573-578

Thomas, AW., Deans, JA., Mitchell, GH., Alderson, T. and Cohen, S., (1984). The Fab fragments of monoclonal IgG to a merozoite surface antigen inhibit Plasmodium knowlesi invasion of erythrocytes. Molecular and Biochemical Parasitology. 13 (2), 187-199

Mitchell, GH., (1984). Vaccination against malaria: its plausibility and the present state of research. Vaccine. 2 (2), 115-124

Facer, CA. and Mitchell, GH., (1984). Wrb NEGATIVE ERYTHROCYTES ARE SUSCEPTIBLE TO INVASION BY MALARIA PARASITES. The Lancet. 324 (8405), 758-759

JACKSON, S., MOLDOVEANU, Z., KIRK, KA., JULIAN, BA., PATTERSON, TF., MULLINS, AL., JILLING, T., MESTECKY, J. and GALLA, JH., (1982). IgA-containing immune complexes after challenge with food antigens in patients with IgA nephropathy. Clinical & Experimental Immunology. 89 (2), 315-320

Deans, JA., Alderson, T., Thomas, AW., Mitchell, GH., Lennox, ES. and Cohen, S., (1982). Rat monoclonal antibodies which inhibit the in vitro multiplication of Plasmodium knowlesi. Clinical and Experimental Immunology. 49 (2), 297-309

Mitchell, GH., Cohen, S., Black, CDV., Voller, A., Dietrich, FM. and Dukor, P., (1981). Novel adjuvants in malaria vaccination. Transactions of the Royal Society of Tropical Medicine and Hygiene. 75 (1), 187-188

Wickham, JM., Dennis, ED. and Mitchell, GH., (1980). Long term cultivation of a simian malaria parasite (Plasmodium knowlesi) in a semi-automated apparatus. Transactions of the Royal Society of Tropical Medicine and Hygiene. 74 (6), 789-792

Mitchell, GH., Richards, WHG., Voller, A., Dietrich, FM. and Dukor, P., (1979). Nor-MDP, saponin, corynebacteria, and pertussis organisms as immunological adjuvants in experimental malaria vaccination of macaques. Bulletin of the World Health Organization. 57 (Suppl. 1), 189-197

Cohen, S. and Mitchell, GH., (1978). Prospects for Immunisation Against Malaria. Current Topics in Microbiology and Immunology. 80, 97-137

Butcher, GA., Mitchell, GH. and Cohen, S., (1978). Antibody mediated mechanisms of immunity to malaria induced by vaccination with Plasmodium knowlesi merozoites. Immunology. 34 (1), 77-86

Richards, WHG., Mitchell, GH., Butcher, GA. and Cohen, S., (1977). Merozoite vaccination of rhesus monkeys against plasmodium knowlesi malaria; immunity to sporozoite (mosquito-transmitted) challenge. Parasitology. 74 (2), 191-198

Cohen, S., Butcher, GA. and Mitchell, GH., (1977). Immunization Against Erythrocytic Forms of Malaria Parasites. Advances in experimental medicine and biology. 93, 89-112

Mitchell, GH., Butcher, GA., Richards, WHG. and Cohen, S., (1977). MEROZOITE VACCINATION OF DOUROUCOULI MONKEYS AGAINST FALCIPARUM MALARIA. The Lancet. 309 (8026), 1335-1338

Bannister, LH., Butcher, GA. and Mitchell, GH., (1977). Recent advances in understanding the invasion of erythrocytes by merozoites of Plasmodium knowlesi. Bulletin of the World Health Organization. 55 (2-3), 163-169

Cohen, S., Langhorne, J., Butcher, GA., Mitchell, GH. and Deans, JA., (1977). Acquired Immunity and Vaccination in Malaria. The American Journal of Tropical Medicine and Hygiene. 26 (6_Part_2), 223-232

Mitchell, GH., Butcher, GA., Langhorne, J. and Cohen, S., (1977). A freeze dried merozoite vaccine effective against Plasmodium knowlesi malaria. Clinical and Experimental Immunology. 28 (1), 276-279

Mitchell, GH., (1977). A review of merozoite vaccination against Plasmodium knowlesi malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. 71 (4), 281-282

Mitchell, GH., Butcher, GA., Voller, A. and Cohen, S., (1976). The effect of human immune IgG on the in vitro development of Plasmodium falciparum. Parasitology. 72 (2), 149-162

Bannister, LH., Butcher, GA., Dennis, ED. and Mitchell, GH., (1975). Studies on the structure and invasive behaviour of merozoites of Plasmodium knowlesi.. Transactions of the Royal Society of Tropical Medicine and Hygiene. 69 (1), 5-

Bannister, LH., Butcher, GA., Dennis, ED. and Mitchell, GH., (1975). Structure and invasive behaviour ofPlasmodium knowlesimerozoitesin vitro. Parasitology. 71 (3), 483-491

Dennis, ED., Mitchell, GH., Butcher, GA. and Cohen, S., (1975). In vitro isolation of Plasmodium knowlesi merozoites using polycarbonate sieves. Parasitology. 71 (3), 475-481

Mitchell, GH., Butcher, GA. and Cohen, S., (1975). Merozoite vaccination against Plasmodium knowlesi malaria. Immunological Communications. 29 (2), 397-407

Cohen, S., Butcher, GA. and Mitchell, GH., (1974). Mechanisms of immunity to malaria. Bulletin of the World Health Organization. 50 (3-4), 251-257

MITCHELL, GH., BUTCHER, GA. and COHEN, S., (1974). A merozoite vaccine effective against Plasmodium knowlesi malaria. Nature. 252 (5481), 311-313

Mitchell, GH., Butcher, GA. and Cohen, S., (1973). Isolation of blood-stage merozoites from Plasmodium knowlesi malaria. International Journal for Parasitology. 3 (3), 443-445

BUTCHER, GA., MITCHELL, GH. and COHEN, S., (1973). Mechanism of Host Specificity in Malarial Infection. Nature. 244 (5410), 40-42

Books (1)

FOWLER, R., MARGOS, G. and MITCHELL, G., (2003). The Cytoskeleton and Motility in Apicomplexan Invasion. Elsevier. 9780120317561

Conferences (1)

Chaparro-Olaya, J., Dluzewski, AR., Margos, G., Wasserman, MM., Mitchell, GH., Bannister, LH. and Pinder, JC., (2003). The multiple myosins of malaria: The smallest malaria myosin, Plasmodium falciparum myosin-B (Pfmyo-B) is expressed in mature schizonts and merozoites

Other (1)

Dobson, A., (2001).Invertebrates are here again. Trends in Parasitology. 17(12),Elsevier BV

Contact

gmitch@essex.ac.uk
+44 (0) 1206 876002

Location:

3SW.4.09, Colchester Campus