People

Professor Elena Klenova

Emeritus Professor
School of Life Sciences
Professor Elena Klenova

Profile

Biography

I joined the Department of Biological Sciences in January 2001 as a Lecturer in Molecular Biology. My education: I graduated from the Moscow State University with the M.Sc. degree in Virology in 1982 and obtained my D.Phil. degree in Genetics at The Institute of General Genetics of the USSR Academy of Science in 1988. My research experience: 1996 2000 - Departmental Lecturer at the Genetics Unit, Department of Biochemistry, University of Oxford. 1992 - 1996 - Fellow of the European Molecular Biology Organization (EMBO) and International Human Frontier Science Program ( HFSPO ) Long-Term Fellowships at the Institute of Cancer Research, London. 1989-1991 Senior Research Fellow, Institute of Carcinogenesis, All-Union Cancer Research Center, Moscow, USSR. 1982-1989 Junior Research Fellow, The Institute of General Genetics, All-Union Academy of Science, Moscow, USSR. I would be very interested to receive enquiries concerning research opportunities in my laboratory from D.Phil. students, Visiting and Post-Doctoral Scientists. Dr Klenova's laboratory Research Students Mrs Lydumyla Pavlova MD Student (Clinical Fellow): Gurvir Josan (co-supervisor)

Research and professional activities

Research interests

My main research interests lie in the areas of regulation of transcription and molecular mechanisms of tumourigenesis.

We study the biological role of two related proteins, CTCF and BORIS, in genetics, epigenetics and disease, particularly, in tumourigenesis. CTCF and BORIS belong to a group of Zinc Finger transcription factors and share an identical DNA binding domain. Although related, CTCF and BORIS have different functions. CTCF has properties of a tumour suppressor, whereas BORIS has features of an oncogene. CTCF is present in various cell types, whereas BORIS normally is found only in the testis. Importantly, BORIS is activated in many cancers and could potentially be used as cancer biomarker.

My research projectshave beenfunded by various granting bodies, which include Councils and Charities such as The Medical Research Council (MRC), The Wellcome Trust, BBSRC, Association for International Cancer Research, Breast Cancer Campaign, Association for International Cancer Research, BreastCancer Research Trust, NHSand others.

Teaching and supervision

Previous supervision

Lyudmyla Pavlova
Lyudmyla Pavlova
Thesis title: Discovery and Validation of Novel Blood Biomarkers of Breast and Prostate Cancer
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 29/11/2018
Shaza Alkhatib
Shaza Alkhatib
Thesis title: Investigation of the Immunological Differences Between Granulocytes From Healthy Donors and Breast Cancer Patients, with Respect to the Cancer Testis Antigen, Ctcfl
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 19/4/2016
Ioanna Pavlaki
Ioanna Pavlaki
Thesis title: Role of Ctcf Poly(Adp-Ribosyl)Ation in the Regulation of Cellular Functions
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 22/12/2015
Jayakumar Mani
Jayakumar Mani
Thesis title: Identification and Validation of Biomarkers for Breast Cancer From Human White Blood Cells
Degree subject: Biological Sciences: Immunology
Degree type: Doctor of Philosophy
Awarded date: 17/11/2015
Olayinka Azeez Oloko
Olayinka Azeez Oloko
Thesis title: The Identification and Validation of DrUG Targets for Prostate Cancer Using Integrated Approaches
Degree subject: Biological Sciences
Degree type: Doctor of Philosophy
Awarded date: 12/9/2014
Nikhil Pawa
Nikhil Pawa
Thesis title: Identification and Validation of New Biomarkers for the Diagnosis and Management of Colorectal Cancer
Degree subject: Medicine
Degree type: Doctor of Medicine
Awarded date: 5/9/2014
Daruliza Kernain Binti Mohd Azman
Daruliza Kernain Binti Mohd Azman
Degree subject: Occasional Study: Biological Sciences (Research)
Degree type: Occasional Postgraduate Study
Awarded date: 1/9/2014
Zubair Ahmad Cheema
Zubair Ahmad Cheema
Thesis title: Assessment of the Boris Protein as a Potential Blood and Tissue Biomarker of Prostate Cancer
Degree subject: Medicine
Degree type: Doctor of Medicine
Awarded date: 3/7/2014
Rosie Alexandra Bryan
Rosie Alexandra Bryan
Thesis title: Analysis of Selected Regulatory Ctcf and Boris Target Genes in Prostate Cancer Cells
Degree subject: Cell and Molecular Biology
Degree type: Master of Science (by Dissertation)
Awarded date: 16/5/2014
Yukti Hari Gupta
Yukti Hari Gupta
Thesis title: An Investigation Into Boris Expression in Prostate Cancer Cells and its Role in Epigenetic Regulation of the Androgen Receptor Gene
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 16/4/2014
Anuradha Apte
Anuradha Apte
Thesis title: Novel Biomarkers for Breast Cancer Early Diagnosis and Treatment Monitoring
Degree subject: Medicine
Degree type: Doctor of Medicine
Awarded date: 21/11/2013
Svetlana Vladimirovna Gretton
Svetlana Vladimirovna Gretton
Thesis title: Investigation of the Functional Role of the Transcription Factor, Ctcf, in the Regulation of Human Bax and P14Arf Genes
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 14/2/2013
Adhip Mandal
Adhip Mandal
Thesis title: Leukocyte Based Biomarkers as Screening and Prognostic Tools for Breast Cancer
Degree subject: Medicine
Degree type: Doctor of Medicine
Awarded date: 15/11/2011

Publications

Journal articles (57)

Teo Hansen Selnø, A., Schlichtner, S., Yasinska, IM., Sakhnevych, SS., Fiedler, W., Wellbrock, J., Berger, SM., Klenova, E., Gibbs, BF., Fasler-Kan, E. and Sumbayev, VV., (2021). High Mobility Group Box 1 (HMGB1) Induces Toll-Like Receptor 4-Mediated Production of the Immunosuppressive Protein Galectin-9 in Human Cancer Cells. Frontiers in Immunology. 12, 675731-

Selnø, ATH., Schlichtner, S., Yasinska, IM., Sakhnevych, SS., Fiedler, W., Wellbrock, J., Klenova, E., Pavlova, L., Gibbs, BF., Degen, M., Schnyder, I., Aliu, N., Berger, SM., Fasler-Kan, E. and Sumbayev, VV., (2020). Transforming growth factor beta type 1 (TGF-β) and hypoxia-inducible factor 1 (HIF-1) transcription complex as master regulators of the immunosuppressive protein galectin-9 expression in human cancer and embryonic cells. Aging. 12 (23), 23478-23496

Yasinska, IM., Sakhnevych, SS., Pavlova, L., Teo Hansen Selnø, A., Teuscher Abeleira, AM., Benlaouer, O., Gonçalves Silva, I., Mosimann, M., Varani, L., Bardelli, M., Hussain, R., Siligardi, G., Cholewa, D., Berger, SM., Gibbs, BF., Ushkaryov, YA., Fasler-Kan, E., Klenova, E. and Sumbayev, VV., (2019). The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer. Frontiers in Immunology. 10 (JULY), 1594-

Pavlaki, I., Docquier, F., Chernukhin, I., Kita, G., Gretton, S., Clarkson, CT., Teif, VB. and Klenova, E., (2018). Poly(ADP-ribosyl)ation associated changes in CTCF-chromatin binding and gene expression in breast cells. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1861 (8), 781-730

Venkatraman, B. and Klenova, E., (2015). Role of CTCF poly(ADP-Ribosyl)ation in the regulation of apoptosis in breast cancer cells. Indian Journal of Medical and Paediatric Oncology. 36 (01), 49-54

Cheema, Z., Hari-Gupta, Y., Kita, G-X., Farrar, D., Seddon, I., Corr, J. and Klenova, E., (2014). Expression of the cancer-testis antigen BORIS correlates with prostate cancer. The Prostate. 74 (2), 164-176

Méndez-Catalá, CF., Gretton, S., Vostrov, A., Pugacheva, E., Farrar, D., Ito, Y., Docquier, F., Kita, G-X., Murrell, A., Lobanenkov, V. and Klenova, E., (2013). A Novel Mechanism for CTCF in the Epigenetic Regulation of Bax in Breast Cancer Cells. Neoplasia. 15 (8), 898-IN14

Guastafierro, T., Catizone, A., Calabrese, R., Zampieri, M., Martella, O., Bacalini, MG., Reale, A., Di Girolamo, M., Miccheli, M., Farrar, D., Klenova, E., Ciccarone, F. and Caiafa, P., (2013). ADP-ribose polymer depletion leads to nuclear Ctcf re-localization and chromatin rearrangement1. Biochemical Journal. 449 (3), 623-630

Chernukhin, I., Kang, SY., Brown, S., Gretton, S., Mendez-Catala, CF., Cowieson, D. and Klenova, E., (2011). BioVyon Protein A, an alternative solid-phase affinity matrix for chromatin immunoprecipitation. Analytical Biochemistry. 412 (2), 183-188

Farrar, D., Chernukhin, I. and Klenova, E., (2011). Generation of Poly(ADP-ribosyl)ation Deficient Mutants of the Transcription Factor, CTCF. Methods in Molecular Biology. 780, 293-312

Ohlsson, R., Lobanenkov, V. and Klenova, E., (2010). Does CTCF mediate between nuclear organization and gene expression?. BioEssays. 32 (1), 37-50

Farrar, D., Rai, S., Chernukhin, I., Jagodic, M., Ito, Y., Yammine, S., Ohlsson, R., Murrell, A. and Klenova, E., (2010). Mutational Analysis of the Poly(ADP-Ribosyl)ation Sites of the Transcription Factor CTCF Provides an Insight into the Mechanism of Its Regulation by Poly(ADP-Ribosyl)ation. Molecular and Cellular Biology. 30 (5), 1199-1216

Ali, FR., Vasiliou, SA., Haddley, K., Paredes, UM., Roberts, JC., Miyajima, F., Klenova, E., Bubb, VJ. and Quinn, JP., (2010). Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF. Journal of Neurochemistry. 112 (1), 296-306

Docquier, F., Kita, G-X., Farrar, D., Jat, P., O'Hare, M., Chernukhin, I., Gretton, S., Mandal, A., Alldridge, L. and Klenova, E., (2009). Decreased Poly(ADP-Ribosyl)ation of CTCF, a Transcription Factor, Is Associated with Breast Cancer Phenotype and Cell Proliferation. Clinical Cancer Research. 15 (18), 5762-5771

Ito, Y., Koessler, T., Ibrahim, AEK., Rai, S., Vowler, SL., Abu-Amero, S., Silva, A-L., Maia, A-T., Huddleston, JE., Uribe-Lewis, S., Woodfine, K., Jagodic, M., Nativio, R., Dunning, A., Moore, G., Klenova, E., Bingham, S., Pharoah, PDP., Brenton, JD., Beck, S., Sandhu, MS. and Murrell, A., (2008). Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer. Human Molecular Genetics. 17 (17), 2633-2643

D'Arcy, V., Pore, N., Docquier, F., Abdullaev, ZK., Chernukhin, I., Kita, G-X., Rai, S., Smart, M., Farrar, D., Pack, S., Lobanenkov, V. and Klenova, E., (2008). BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours. British Journal of Cancer. 98 (3), 571-579

D'Arcy, V., Pore, N., Docquier, F., Abdullaev, ZK., Chernukhin, I., Kita, G-X., Rai, S., Smart, M., Farrar, D., Pack, S., Lobanenkov, V. and Klenova, E., (2008). Erratum: BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours. British Journal of Cancer. 98 (3), 676-676

Hancock, AL., Brown, KW., Moorwood, K., Moon, H., Holmgren, C., Mardikar, SH., Dallosso, AR., Klenova, E., Loukinov, D., Ohlsson, R., Lobanenkov, VV. and Malik, K., (2007). A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis. Human Molecular Genetics. 16 (3), 343-354

Roberts, J., Scott, AC., Howard, MR., Breen, G., Bubb, VJ., Klenova, E. and Quinn, JP., (2007). Differential Regulation of the Serotonin Transporter Gene by Lithium Is Mediated by Transcription Factors, CCCTC Binding Protein and Y-Box Binding Protein 1, through the Polymorphic Intron 2 Variable Number Tandem Repeat. Journal of Neuroscience. 27 (11), 2793-2801

Chernukhin, I., Shamsuddin, S., Kang, SY., Bergström, R., Kwon, Y-W., Yu, W., Whitehead, J., Mukhopadhyay, R., Docquier, F., Farrar, D., Morrison, I., Vigneron, M., Wu, S-Y., Chiang, C-M., Loukinov, D., Lobanenkov, V., Ohlsson, R. and Klenova, E., (2007). CTCF Interacts with and Recruits the Largest Subunit of RNA Polymerase II to CTCF Target Sites Genome-Wide. Molecular and Cellular Biology. 27 (5), 1631-1648

D'Arcy, V., Abdullaev, ZK., Pore, N., Docquier, F., Torrano, V., Chernukhin, I., Smart, M., Farrar, D., Metodiev, M., Fernandez, N., Richard, C., Delgado, MD., Lobanenkov, V. and Klenova, E., (2006). The Potential of BORIS Detected in the Leukocytes of Breast Cancer Patients as an Early Marker of Tumorigenesis. Clinical Cancer Research. 12 (20), 5978-5986

Torrano, V., Navascués, J., Docquier, F., Zhang, R., Burke, LJ., Chernukhin, I., Farrar, D., León, J., Berciano, MT., Renkawitz, R., Klenova, E., Lafarga, M. and Delgado, MD., (2006). Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism. Journal of Cell Science. 119 (9), 1746-1759

Torrano, V., Chernukhin, I., Docquier, F., D'Arcy, V., León, J., Klenova, E. and Delgado, MD., (2005). CTCF Regulates Growth and Erythroid Differentiation of Human Myeloid Leukemia Cells. Journal of Biological Chemistry. 280 (30), 28152-28161

Docquier, F., Farrar, D., D'Arcy, V., Chernukhin, I., Robinson, AF., Loukinov, D., Vatolin, S., Pack, S., Mackay, A., Harris, RA., Dorricott, H., O'Hare, MJ., Lobanenkov, V. and Klenova, E., (2005). Heightened Expression of CTCF in Breast Cancer Cells Is Associated with Resistance to Apoptosis. Cancer Research. 65 (12), 5112-5122

Klenova, E. and Ohlsson, R., (2005). Poly(ADP-ribosyl)ation and Epigenetics: Is CTCF PARt of the Plot?. Cell Cycle. 4 (1), 96-101

El-Kady, A. and Klenova, E., (2005). Regulation of the transcription factor, CTCF, by phosphorylation with protein kinase CK2. FEBS Letters. 579 (6), 1424-1434

Yu, W., Ginjala, V., Pant, V., Chernukhin, I., Whitehead, J., Docquier, F., Farrar, D., Tavoosidana, G., Mukhopadhyay, R., Kanduri, C., Oshimura, M., Feinberg, AP., Lobanenkov, V., Klenova, E. and Ohlsson, R., (2004). Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nature Genetics. 36 (10), 1105-1110

Pant, V., Kurukuti, S., Pugacheva, E., Shamsuddin, S., Mariano, P., Renkawitz, R., Klenova, E., Lobanenkov, V. and Ohlsson, R., (2004). Mutation of a Single CTCF Target Site within the H19 Imprinting Control Region Leads to Loss of Igf2 Imprinting and Complex Patterns of De Novo Methylation upon Maternal Inheritance. Molecular and Cellular Biology. 24 (8), 3497-3504

Klenova, E., (2004). YB-1 and CTCF Differentially Regulate the 5-HTT Polymorphic Intron 2 Enhancer Which Predisposes to a Variety of Neurological Disorders. Journal of Neuroscience. 24 (26), 5966-5973

Mukhopadhyay, R., (2004). The Binding Sites for the Chromatin Insulator Protein CTCF Map to DNA Methylation-Free Domains Genome-Wide. Genome Research. 14 (8), 1594-1602

Klenova, E., (2002). Immunoprecipitation techniques for the analysis of transcription factor complexes. Methods. 26 (3), 254-259

Filippova, GN., Ulmer, JE., Moore, JM., Ward, MD., Hu, YJ., Neiman, PE., Collins, SJ., Qi, CF., Loukinov, DI., Pugacheva, EM., Morse, HC., Lobanenkov, VV., Klenova, EM., Grundy, PE., Feinberg, AP., Cleton-Jansen, AM., Moerland, EW., Cornelisse, CJ., Suzuki, H., Komiya, A., Lindblom, A. and Dorion-Bonnet, F., (2002). Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter its DNA-binding specificity. Cancer Research. 62 (1), 48-52

Klenova, EM., Morse, HC., Ohlsson, R. and Lobanenkov, VV., (2002). The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. Seminars in Cancer Biology. 12 (5), 399-414

Loukinov, DI., Pugacheva, E., Vatolin, S., Pack, SD., Moon, H., Chernukhin, I., Mannan, P., Larsson, E., Kanduri, C., Vostrov, AA., Cui, H., Niemitz, EL., Rasko, JEJ., Docquier, FM., Kistler, M., Breen, JJ., Zhuang, Z., Quitschke, WW., Renkawitz, R., Klenova, EM., Feinberg, AP., Ohlsson, R., Morse, HC. and Lobanenkov, VV., (2002). BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proceedings of the National Academy of Sciences. 99 (10), 6806-6811

Klenova, EM., Chernukhin, IV., El-Kady, A., Lee, RE., Pugacheva, EM., Loukinov, DI., Goodwin, GH., Delgado, D., Filippova, GN., León, J., Morse, HC., Neiman, PE. and Lobanenkov, VV., (2001). Functional Phosphorylation Sites in the C-Terminal Region of the Multivalent Multifunctional Transcriptional Factor CTCF. Molecular and Cellular Biology. 21 (6), 2221-2234

Rasko, JEJ., Klenova, EM., Leon, J., Filippova, GN., Loukinov, DI., Vatolin, S., Robinson, AF., Jia Hu, Y., Ulmer, J., Ward, MD., Pugacheva, EM., Neiman, PE., Morse, HC., Collins, SJ. and Lobanenkov, VV., (2001). Cell growth inhibition by the multifunctional multivalent zinc-finger factor CTCF. Cancer Research. 61 (16), 6002-6007

Chernukhin, IV., Shamsuddin, S., Robinson, AF., Carne, AF., Paul, A., El-Kady, AI., Lobanenkov, VV. and Klenova, EM., (2000). Physical and Functional Interaction between Two Pluripotent Proteins, the Y-box DNA/RNA-binding Factor, YB-1, and the Multivalent Zinc Finger Factor, CTCF. Journal of Biological Chemistry. 275 (38), 29915-29921

Chernukhin, IV. and Klenova, EM., (2000). A Method of Immobilization on the Solid Support of Complex and Simple Enzymes Retaining Their Activity. Analytical Biochemistry. 280 (1), 178-181

Delgado, MD., Chernukhin, IV., Bigas, A., Klenova, EM. and León, J., (1999). Differential expression and phosphorylation of CTCF, a c-myctranscriptional regulator, during differentiation of human myeloid cells. FEBS Letters. 444 (1), 5-10

Filippova, GN., Lindblom, A., Meincke, LJ., Klenova, EM., Neiman, PE., Collins, SJ., Doggett, NA. and Lobanenkov, VV., (1998). A widely expressed transcription factor with multiple DNA sequence specificity,CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers. Genes, Chromosomes and Cancer. 22 (1), 26-36

Klenova, EM., Fagerlie, S., Filippova, GN., Kretzner, L., Goodwin, GH., Loring, G., Neiman, PE. and Lobanenkov, VV., (1998). Characterization of the Chicken CTCF Genomic Locus, and Initial Study of the Cell Cycle-regulated Promoter of the Gene. Journal of Biological Chemistry. 273 (41), 26571-26579

Klenova, E., (1997). Molecular weight abnormalities of the CTCF transcription factor: CTCF migrates aberrantly in SDS-PAGE and the size of the expressed protein is affected by the UTRs and sequences within the coding region of the CTCF gene. Nucleic Acids Research. 25 (3), 466-474

Filippova, GN., Fagerlie, S., Klenova, EM., Myers, C., Dehner, Y., Goodwin, G., Neiman, PE., Collins, SJ. and Lobanenkov, VV., (1996). An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Molecular and Cellular Biology. 16 (6), 2802-2813

Klenova, EM., Nicolas, RH., Paterson, HF., Carne, AF., Heath, CM., Goodwin, GH., Neiman, PE. and Lobanenkov, VV., (1993). CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms.. Molecular and Cellular Biology. 13 (12), 7612-7624

Klenova, EM., Botezato, I., Laudet, V., Goodwin, GH., Wallace, JC. and Lobanenkov, VV., (1992). Isolation of a cDNA clone encoding the RNASE-superfamily-related gene highly expressed in chicken bone marrow cells. Biochemical and Biophysical Research Communications. 185 (1), 231-239

Adler, VV., Kiseleva, NP., Kistanova, EN., Klenova, EM., Lobanenkov, VV., Polotskaya, AV. and Tevosyan, SG., (1991). Differences in expression and functional organization of rat tyrosine aminotransferase gene in two Morris hepatoma cell lines 7777 and 8994. Molekulyarnaya Biologiya. 25 (2), 431-441

Kintsurashvili, EG., Adler, VV., Klenova, EM., Lobanenkov, VV. and Razin, SV., (1990). Multiple DNA recognition sites by sequence-specific DNA-binding proteins in the region of replication initiation site located 5-end upstream to the chicken alpha-globin gene domain. Doklady Akademii nauk SSSR. 310 (1), 227-228

Kintsurashvili, EG., Adler, VV., Klenova, EM., Lobanenkov, VV. and Razin, SV., (1990). Multiple recognition sites for DNA by sequence-specific DNA-binding proteins in the neighborhood of the site of the beginning of replication, situated in the 5-terminal region of the domain of chicken α-globin genes. Doklady Biochemistry. 310 (1-6), 9-11

Kabishev, AA., Klenova, EM., Gribanovskiǐ, VA. and Gorodetskiǐ, SI., (1990). The identification of the binding sites of nuclear factor I in the region of the bovine beta-casein gene. Doklady Akademii nauk SSSR. 315 (4), 997-1000

Lobanenkov, VV., Nicolas, RH., Adler, VV., Paterson, H., Klenova, EM., Polotskaja, AV. and Goodwin, GH., (1990). A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene. Oncogene. 5 (12), 1743-1753

Klenova, EM., Adler, VV. and Lobanenkov, VV., (1989). In vitro formation of multimers of specific DNA-protein complexes with nuclear factor I (NF I). Doklady Akademii nauk SSSR. 306 (4), 995-998

Klenova, EM., Adler, VV., Gribanovsky, VA., Gorodetsky, SI., Bogdanova, NN. and Lobanenkov, VV., (1989). Specific interaction of a nuclear protein factor from the CTF/NF-I family with two distinct promoter regions of the rat tyrosine aminotransferase gene. Molekulyarnaya Biologiya. 23 (5), 1400-1415

Klenova, EM., Polotskaya, AV., Adler, VV., Gorodetsky, SI., Gribanovsky, VA. and Lobanenkov, VV., (1989). A rat-liver nuclear protein factor A5 that requires metal to interact specifically with the distal promoter element of the tyrosine aminotransferase gene in vitro. Molekulyarnaya Biologiya. 23 (5), 1416-1427

Klenova, EM., Adler, VV. and Lobanenkov, VV., (1989). In vitro formation of multimers of specific DNA-protein complexes with nuclear factor I (NF I). Doklady Biochemistry. 306 (1-6), 157-160

Lobanenkov, VV., Klenova, EM., Gorodetskii, SI. and Adler, VV., (1988). DNA-binding nuclear protein factors that interact specifically with the elements of the promoter of the rat tyrosine aminotransferase gene. Doklady Biochemistry. 298 (1-6), 11-16

Lobanenkov, VV., Klenova, EM., Gorodetskiǐ, SI. and Adler, VV., (1988). DNA-binding nuclear protein factors specifically binding with the promoter elements of the tyrosine aminotransferase gene in the rat. Doklady Akademii nauk SSSR. 298 (3), 746-750

Klenova, EM., Desiatnikov, OO., Bulachev, VN. and Gorodetskiǐ, SI., (1988). Change in the level of casein mRNA in the mammary gland of rats and goats during lactation. Biokhimiya. 53 (11), 1925-1931

Reports and Papers (1)

Pavlaki, I., Docquier, F., Chernukhin, I., Kita, G., Gretton, S., Teif, V. and Klenova, E., (2018). Poly(ADP-ribosyl)ation associated changes in CTCF-chromatin binding and gene expression in breast cells

Grants and funding

2014

Further validation of new biomarkers of prostate and breast cancer: the continuing investigation

Colchester Hospitals NHS Foundation Trust

Identification and validation of new biomarkers and drug targets for prostate cancer: The continuing investigation

Colchester Hospitals NHS Foundation Trust

2011

Role of poly(ADP-ribosyl)ation of a transcriptional factor

Cancer Research Uk

2010

Clinical Research Fellowship - Zubair Cheema.

Colchester Hospitals NHS Foundation Trust

Identificaton of a human plasma component....

Breast Cancer Campaign

2009

Collaborative Studies - Colchester NHS Trust

Colchester Hospitals NHS Foundation Trust

Clinical Research Fellowship

Colchester Hospitals NHS Foundation Trust

Clinical Research Fellowship - Dr Anu Apte - BORIS

Colchester Hospitals NHS Foundation Trust

Contact

klenovae@essex.ac.uk

Location:

Colchester Campus