2020 applicants
People

Dr Efstathios (Stathis) Giotis

Lecturer
School of Life Sciences
Dr Efstathios (Stathis) Giotis

Profile

Biography

Efstathios (Stathis) Giotis graduated from the School of veterinary medicine (Aristotle University, Greece) in 2001, received his MSc in biotechnology in 2002 and PhD in molecular microbiology in 2006 from the Ulster and Illinois State Universities. Since 2009, he worked at the Roslin Institute, the Royal Veterinary College London, the University of Copenhagen in the field of pathogen-host interactions. Common denominators of his research have been the focus on the interface of human-animal health and the use of transcriptomics technologies to answer scientific questions. Since joining Imperial College London in 2012, his research has moved to focus on the host cell-entry and transmission of zoonotic avian and bat-borne viruses such as avian/bat influenza A viruses, using big data techniques and bioinformatics. He joined the University of Essex in 2020 in order to establish his own group with a primary focus on SARS-CoV-2. He remains affiliated with Imperial College London as an honorary senior research fellow.

Qualifications

  • PhD in Molecular Microbiology Ulster & Illinois State Universities, (2006)

  • MSc in Biotechnology Ulster University, (2002)

  • Doctor in Veterinary Medicine Aristotle University of Thessaloniki, (2001)

Teaching and supervision

Current teaching responsibilities

  • Immunity in Health and Disease (BS223)

  • Issues in Biomedical Science (BS306)

Publications

Journal articles (31)

Dulwich, KL., Asfor, A., Gray, A., Giotis, ES., Skinner, MA. and Broadbent, AJ., (2020). The Stronger Downregulation of in vitro and in vivo Innate Antiviral Responses by a Very Virulent Strain of Infectious Bursal Disease Virus (IBDV), Compared to a Classical Strain, Is Mediated, in Part, by the VP4 Protein. Frontiers in Cellular and Infection Microbiology. 10, 315-

Giotis, ES., (2020). Inferring the Urban Transmission Potential of Bat Influenza Viruses. Frontiers in Cellular and Infection Microbiology. 10, 264-

Liu, PJ., Harris, JM., Marchi, E., D’Arienzo, V., Michler, T., Wing, PAC., Magri, A., Ortega-Prieto, AM., van de Klundert, M., Wettengel, J., Durantel, D., Dorner, M., Klenerman, P., Protzer, U., Giotis, ES. and McKeating, JA., (2020). Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models. Scientific Reports. 10 (1), 14101-

Giotis, ES., Laidlaw, SM., Bidgood, SR., Albrecht, D., Burden, JJ., Robey, RC., Mercer, J. and Skinner, MA., (2020). Modulation of early host innate immune response by a Fowlpox virus (FWPV) lateral body protein

Oliveira, M., Rodrigues, DR., Guillory, V., Kut, E., Giotis, ES., Skinner, MA., Guabiraba, R., Bryant, CE. and Ferguson, BJ., (2020). Chicken cGAS senses fowlpox virus infection and regulates macrophage effector functions

Giotis, ES., Montillet, G., Pain, B. and Skinner, MA., (2019). Chicken Embryonic-Stem Cells Are Permissive to Poxvirus Recombinant Vaccine Vectors.. Genes. 10 (3), 237-237

Mariatulqabtiah, AR., Majid, NN., Giotis, ES., Omar, AR. and Skinner, MA., (2019). Inoculation of fowlpox viruses coexpressing avian influenza H5 and chicken IL-15 cytokine gene stimulates diverse host immune responses. Asia-Pacific Journal of Molecular Biology and Biotechnology. 27 (1), 84-94

Giotis, ES., Carnell, G., Young, EF., Ghanny, S., Soteropoulos, P., Wang, L-F., Barclay, WS., Skinner, MA. and Temperton, N., (2019). Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor. Nature Microbiology. 4 (12), 2035-2038

Giotis, ES. and Skinner, MA., (2019). Spotlight on avian pathology: fowlpox virus. Avian Pathology. 48 (2), 87-90

Giotis, ES., Scott, A., Rothwell, L., Hu, T., Talbot, R., Todd, D., Burt, DW., Glass, EJ. and Kaiser, P., (2018). Chicken anaemia virus evades host immune responses in transformed lymphocytes. Journal of General Virology. 99 (3), 321-327

Tierney, M., Gallagher, AM., Giotis, ES. and Pentieva, K., (2017). An Online Survey on Consumer Knowledge and Understanding of Added Sugars.. Nutrients. 9 (1), 37-37

Dulwich, KL., Giotis, ES., Gray, A., Nair, V., Skinner, MA. and Broadbent, AJ., (2017). Differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV).. The Journal of general virology. 98 (12), 2918-2930

Giotis, ES., Ross, CS., Robey, RC., Nohturfft, A., Goodbourn, S. and Skinner, MA., (2017). Constitutively elevated levels of SOCS1 suppress innate responses in DF-1 immortalised chicken fibroblast cells.. Scientific Reports. 7 (1), 17485-

Giotis, ES., Robey, RC., Skinner, NG., Tomlinson, CD., Goodbourn, S. and Skinner, MA., (2016). Chicken interferome: avian interferon-stimulated genes identified by microarray and RNA-seq of primary chick embryo fibroblasts treated with a chicken type I interferon (IFN-α).. Veterinary Research. 47 (1), 75-

Long, JS., Giotis, ES., Moncorgé, O., Frise, R., Mistry, B., James, J., Morisson, M., Iqbal, M., Vignal, A., Skinner, MA. and Barclay, WS., (2016). Species difference in ANP32A underlies influenza A virus polymerase host restriction.. Nature. 529 (7584), 101-104

Giotis, ES., Rothwell, L., Scott, A., Hu, T., Talbot, R., Todd, D., Burt, DW., Glass, EJ. and Kaiser, P., (2015). Transcriptomic Profiling of Virus-Host Cell Interactions following Chicken Anaemia Virus (CAV) Infection in an In Vivo Model.. PLoS One. 10 (8), e0134866-e0134866

Kennedy, TG., Giotis, ES. and McKevitt, AI., (2014). Microbial assessment of an upward and downward dehiding technique in a commercial beef processing plant. Meat Science. 97 (4), 486-489

Wheatley, P., Giotis, ES. and McKevitt, AI., (2014). Effects of slaughtering operations on carcass contamination in an Irish pork production plant.. Irish Veterinary Journal. 67 (1), 1-1

Laidlaw, SM., Robey, R., Davies, M., Giotis, ES., Ross, C., Buttigieg, K., Goodbourn, S. and Skinner, MA., (2013). Genetic Screen of a Mutant Poxvirus Library Identifies an Ankyrin Repeat Protein Involved in Blocking Induction of Avian Type I Interferon. Journal of Virology. 87 (9), 5041-5052

Giotis, ES., Loeffler, A., Knight-Jones, T. and Lloyd, DH., (2012). Development of a skin colonization model in gnotobiotic piglets for the study of the microbial ecology of meticillin-resistant Staphylococcus aureus ST398. Journal of Applied Microbiology. 113 (4), 992-1000

Carson, M., Meredith, AL., Shaw, DJ., Giotis, ES., Lloyd, DH. and Loeffler, A., (2012). Foxes As a Potential Wildlife Reservoir formecA-Positive Staphylococci. Vector-Borne and Zoonotic Diseases. 12 (7), 583-587

Porphyre, T., Giotis, ES., Lloyd, DH. and Stärk, KDC., (2012). A metapopulation model to assess the capacity of spread of meticillin-resistant Staphylococcus aureus ST398 in humans.. PLoS One. 7 (10), e47504-e47504

Giotis, ES., Loeffler, A., Lindsay, JA. and Lloyd, DH., (2011). Reduced Sensitivity of Oxacillin-Screening Agar for Detection of MRSA ST398 from Colonized Pigs. Journal of Clinical Microbiology. 49 (8), 3103-3104

Giotis, ES., Muthaiyan, A., Natesan, S., Wilkinson, BJ., Blair, IS. and McDowell, DA., (2010). Transcriptome Analysis of Alkali Shock and Alkali Adaptation inListeria monocytogenes10403S. Foodborne Pathogens and Disease. 7 (10), 1147-1157

Kehrenberg, C., Cuny, C., Strommenger, B., Schwarz, S. and Witte, W., (2009). Methicillin-Resistant and -Susceptible Staphylococcus aureus Strains of Clonal Lineages ST398 and ST9 from Swine Carry the Multidrug Resistance Gene cfr. Antimicrobial Agents and Chemotherapy. 53 (2), 779-781

Pu, S., Han, F. and Ge, B., (2009). Isolation and Characterization of Methicillin-Resistant Staphylococcus aureus Strains from Louisiana Retail Meats. Applied and Environmental Microbiology. 75 (1), 265-267

Singh, VK., Hattangady, DS., Giotis, ES., Singh, AK., Chamberlain, NR., Stuart, MK. and Wilkinson, BJ., (2008). Insertional Inactivation of Branched-Chain α-Keto Acid Dehydrogenase in Staphylococcus aureus Leads to Decreased Branched-Chain Membrane Fatty Acid Content and Increased Susceptibility to Certain Stresses. Applied and Environmental Microbiology. 74 (19), 5882-5890

GIOTIS, ES., JULOTOK, M., WILKINSON, BJ., BLAIR, IS. and MCDOWELL, DA., (2008). Role of Sigma B Factor in the Alkaline Tolerance Response of Listeria monocytogenes 10403S and Cross-Protection against Subsequent Ethanol and Osmotic Stress. Journal of Food Protection. 71 (7), 1481-1485

Giotis, ES., Muthaiyan, A., Blair, IS., Wilkinson, BJ. and McDowell, DA., (2008). Genomic and proteomic analysis of the Alkali-Tolerance Response (AlTR) in Listeria monocytogenes 10403S.. BMC Microbiology. 8 (1), 102-102

Giotis, ES., Blair, IS. and McDowell, DA., (2007). Morphological changes in Listeria monocytogenes subjected to sublethal alkaline stress. International Journal of Food Microbiology. 120 (3), 250-258

Giotis, ES., McDowell, DA., Blair, IS. and Wilkinson, BJ., (2007). Role of Branched-Chain Fatty Acids in pH Stress Tolerance in Listeria monocytogenes. Applied and Environmental Microbiology. 73 (3), 997-1001

Conferences (5)

Giotis, ES., Robey, RR., Ross, C., Goodbourn, SE. and Skinner, MA., (2015). ID: 217

Giotis, ES., Robey, RR., Ross, C., Laidlaw, S., Goodbourn, S. and Skinner, MA., (2015). ID: 130

Ascough, S., Sadeyen, J-R., Giotis, E., Laidlaw, S., Staines, K., Mwangi, W., Hernandez, RR., Skinner, M. and Butter, C., (2014). Potentiating the immunogenicity of poxvirus vectors to improve the efficacy of live recombinant viral vaccines in poultry

Giotis, ES., Blair, IS. and McDowell, DA., (2011). Standardisation and optimisation of the Alkaline-Tolerance Response (A1TR) in Listeria monocytogenes 10403S

Krysa, J., Zita, J., Zlamal, M., Kluson, P., Giotis, ES., Loeffler, A., Stark, KDC. and Lloyd, DA., (2010). Ability of Photocatalytic TiO2 Surfaces to Destroy MRSA ST398 under Controlled UV Light Conditions

Reports and Papers (5)

Liu, PJ., Harris, JM., Marchi, E., D’Arienzo, V., Michler, T., Wing, PAC., Magri, A., Ortega-Prieto, AM., van de Klundert, M., Wettengel, J., Durantel, D., Dorner, M., Klenerman, P., Protzer, U., Giotis, S. and McKeating, JA., (2020). Hypoxic gene expression in chronic hepatitis B infected patients is not observed in state-of-art in vitro and mouse infection models

Dulwich, KL., Asfor, AS., Gray, AG., Giotis, ES., Skinner, MA. and Broadbent, AJ., (2019). The stronger downregulation of in vitro and in vivo innate antiviral responses by a very virulent strain of infectious bursal disease virus (IBDV), compared to a classical strain, is mediated, in part, by the VP4 protein

Giotis, ES., Carnell, G., Young, EF., Ghanny, S., Soteropoulos, P., Barclay, WS., Skinner, MA. and Temperton, N., (2019). The MHC class-II HLA-DR receptor mediates bat influenza A-like H17N10 virus entry into mammalian cells

Carnell, G., Giotis, E., Grehan, K., Ferrara, F., Mather, S., Molesti, E., Scott, S., Pessi, A., Lacek, K. and Temperton, N., (2018). The bat influenza H17N10 can be neutralized by broadly-neutralizing monoclonal antibodies and its neuraminidase can facilitate viral egress.

Dulwich, KL., Giotis, ES., Gray, A., Nair, V., Skinner, MA. and Broadbent, AJ., (2017). Differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV)

Contact

e.giotis@essex.ac.uk

Location:

Colchester Campus