Dr Joaquin De Navascues

School of Life Sciences
Dr Joaquin De Navascues

Research and professional activities

Research interests

Molecular regulation of cell fate decisions

Key words: Gene expression regulation
Open to supervise

Stem cell-based adult tissue homeostasis

Key words: Stem cells
Open to supervise

Late radiation toxicity

Key words: Radiotherapy
Open to supervise

Conferences and presentations

Is the radiosensitivity of fruitflies clinically relevant?

Annual meeting of the Association for Radiation Research, Francis Crick Institute, London, 6/6/2022

Drosophila as a tool for radiobiology

Invited presentation, Drosophila gut meeting, University of Glasgow, Glasgow, 5/5/2022

Modelling late radiation toxicity to normal tissue in Drosophila

Invited presentation, Annual meeting of the Association for Radiation Research, (online), 13/7/2021

Modelling tissue-level responses to radiation in Drosophila

Invited presentation, Annual fly JEDI meeting, University of Essex, Colchester, United Kingdom, 16/9/2019

Teaching and supervision

Current teaching responsibilities

  • Genetics and Evolution (BS102)

  • Transferable Skills in Life Sciences (BS143)

  • Employability Skills for the Biosciences (BS211)

  • Molecular Biology: Genes, Proteins and Disease (BS221)

  • Issues in Biomolecular Science (BS304)

  • Advanced Cancer Biology (BS932)

  • Gene Technology and Synthetic Biology (BS934)

  • Molecular Mechanisms of Disease (BS938)

  • Biomedical Science: Practice and Employability (BS214)

  • Research Project in Life Sciences (BS832)


Journal articles (10)

Guisoni, N., Martinez-Corral, R., Garcia-Ojalvo, J. and de Navascués, J., (2017). Diversity of fate outcomes in cell pairs under lateral inhibition. Development. 144 (7), 1177-1186

Fang, HY., Martinez-Arias, A. and de Navascués, J., (2016). Autocrine and paracrine Wingless signalling in the Drosophila midgut by both continuous gradient and asynchronous bursts of wingless expression. F1000Research. 5, 317-317

Porazinski, S., de Navascués, J., Yako, Y., Hill, W., Jones, MR., Maddison, R., Fujita, Y. and Hogan, C., (2016). EphA2 Drives the Segregation of Ras-Transformed Epithelial Cells from Normal Neighbors. Current Biology. 26 (23), 3220-3229

Jurado, J., de Navascués, J. and Gorfinkiel, N., (2016). α-Catenin stabilises Cadherin–Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction. Journal of Cell Science. 129 (24), 4496-4508

Guisoni, N., Martinez-Corral, R., Garcia Ojalvo, J. and de Navascués, J., (2015). Diversity of fate outcomes in cell pairs under lateral inhibition

de Navascués, J., Perdigoto, CN., Bian, Y., Schneider, MH., Bardin, AJ., Martínez-Arias, A. and Simons, BD., (2012). Drosophilamidgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells. The EMBO Journal. 31 (11), 2473-2485

Muñoz‐Descalzo, S., de Navascues, J. and Arias, AM., (2012). Wnt‐Notch signalling: An integrated mechanism regulating transitions between cell states. BioEssays. 34 (2), 110-118

de Navascués, J. and Modolell, J., (2010). The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila. Mechanisms of Development. 127 (9-12), 393-406

de Navascués, J. and Modolell, J., (2007). tailup, a LIM-HD gene, and Iro-C cooperate inDrosophiladorsal mesothorax specification. Development. 134 (9), 1779-1788

Villa-Cuesta, E., de Navascués, J., Ruiz-Gómez, M., del Corral, RD., Domínguez, M., de Celis, JF. and Modolell, J., (2003). Tufted Is a Gain-of-Function Allele That Promotes Ectopic Expression of the Proneural Gene amos in Drosophila. Genetics. 163 (4), 1403-1412

Grants and funding


Advanced live imaging for the Eastern ARC with dual inverted light-sheets and AI-led analysis

Biotechnology and Biological Sciences Research Council


Acquisition of the Drosophila model system to understand mechanisms of innate immunity regulation by chromatin dynamics

National Centre for the Replacement Refinement & Reduction of Animals in Research


Molecular dynamics of a bHLH transcription factor network in stemness and bi-lineage differentiation in the intestine

The Royal Society

+44 (0) 1206 876585


3SW.3.10, Colchester Campus