People

Dr Philippe Laissue

Senior Research Officer
School of Biological Sciences
Dr Philippe Laissue

Profile

Biography

since Oct. 2015 Royal Society Industry Fellow since 2009 Bioimaging Senior Research Officer, University of Essex, UK 2006 2009 Postdoctoral Research Associate (with Prof A Colchester), University of Kent, UK 2004 2005 Postdoctoral Research Assistant, Biozentrum (University of Basel), CH 2001 2004 PhD, Applied Microbiology and Bioimaging, Biozentrum (University of Basel), CH (Supervisor Prof P Philippsen, Advisor Prof U Aebi) 1993-1999 BSc & MSc in Biology, Université de Fribourg, CH Reviewer for BBSRC, Mic Res Tech, J Microsc, J Histochem Cytochem, Histochem Cell Biol, BMC Bioinformatics, Limnol Oceanogr Meth, Sensors,Handbook of Photonics.

Qualifications

  • 2010 Postgraduate Certificate in Higher Education

  • 2004 PhD (Hons) Biozentrum (University of Basel), CH

  • 1999 MSc in Zoology (Hons), Université de Fribourg, CH

Research and professional activities

Research interests

I have broad experience in advanced optical imaging and biomedical image analysis of different organisms. With a strong background in methods development

designing and teaching new approaches for imaging-based problems.

Current research

- Low-light microscopy for live imaging

- Development of reef-building corals (with Prof D Smith)

- Quantified phenotype analysis (research student: Mrs Rana Alghamdi)

- Metabolic inhibitors of prostate cancer (with Dr Greg Brooke and research student Mrs Amna Allafi)

- The location and signalling mechanisms of hydrogen peroxide in plants (with Prof P Mullineaux)

Funding: Royal Society, NERC, BBSRC,British Retinitis Pigmentosa Society.

Publications

Journals (18)

Mullineaux, PM., Exposito-Rodriguez, M., Laissue, PP. and Smirnoff, N., (2018). ROS-dependent signaling pathways in plants and algae exposed to high light: Comparisons with other eukaryotes. Free Radical Biology and Medicine

Exposito-Rodriguez, M., Laissue, PP., Yvon-Durocher, G., Smirnoff, N. and Mullineaux, PM., (2017). Photosynthesis-dependent H2O2 transfer from chloroplasts to nuclei provides a high-light signalling mechanism. Nature Communications. 8 (1)

Exposito-Rodriguez, M., Laissue, PP., López-Calcagno, PE., Mullineaux, PM., Raines, CA. and Simkin, AJ., (2017). Development of pGEMINI, a Plant Gateway Destination Vector Allowing the Simultaneous Integration of Two cDNA via a Single LR-Clonase Reaction. Plants. 6 (4)

Laissue, PP., Alghamdi, RA., Tomancak, P., Reynaud, EG. and Shroff, H., (2017). Assessing phototoxicity in live fluorescence imaging. Nature Methods. 14 (7)

Nelson, CJ., Duckney, P., Hawkins, TJ., Deeks, MJ., Laissue, PP., Hussey, PJ. and Obara, B., (2015). Blobs and curves: object-based colocalisation for plant cells. Functional Plant Biology. 42 (5)

Jabeen, A., Miranda-Sayago, JM., Obara, B., Spencer, PS., Dealtry, GB., Hayrabedyan, S., Shaikly, V., Laissue, PP. and Fernández, N., (2013). Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy1. Biology of Reproduction. 89 (4)

Laissue, JA., Bartzsch, S., Blattmann, H., Bräuer-Krisch, E., Bravin, A., Dalléry, D., Djonov, V., Hanson, AL., Hopewell, JW., Kaser-Hotz, B., Keyriläinen, J., Laissue, PP., Miura, M., Serduc, R., Siegbahn, AE. and Slatkin, DN., (2013). Response of the rat spinal cord to X-ray microbeams. Radiotherapy and Oncology. 106 (1)

Obara, B., Jabeen, A., Fernandez, N. and Laissue, PP., (2013). A novel method for quantified, superresolved, three-dimensional colocalisation of isotropic, fluorescent particles. Histochemistry and Cell Biology. 139 (3)

Exposito-Rodriguez, M., Laissue, PP., Littlejohn, GR., Smirnoff, N. and Mullineaux, PM., (2013). The use of HyPer to examine spatial and temporal changes in H2O2in high light-exposed plants. Methods in Enzymology. 527

Avanaki, MRN., Laissue, PP., Eom, TJ., Podoleanu, AG. and Hojjatoleslami, A., (2013). Speckle reduction using an artificial neural network algorithm. Applied Optics. 52 (21)

Spencer, PS., Hakam, SM., Laissue, PP., Jabeen, A., Jain, P., Hayrabedyan, S., Todorova, K., Blanch, A., McElhinney, JM., Muhandiram, N., Alkhatib, S., Dealtry, GB., Miranda-Sayago, JM. and Fernández, N., (2012). Key Cellular Components and Interactive Histocompatibility Molecules Regulating Tolerance to the Fetal Allograft. American Journal of Reproductive Immunology. 68 (2)

Jabeen, A., Jain, P., Laissue, PP., Suhling, K., Levitt, JA., Shaikly, V., Shakhawat, A. and Fern�ndez, N., (2010). Physical interactions of HLA-G with MHC class I partner molecules on the surface of two trophoblast cell lines, JEG-3 and ACH-3P, by Forster resonance energy transfer based on fluorescence lifetime measurements. Journal of reproductive immunology. 86 (2, SI)

Rosen, RB., Hathaway, M., Rogers, J., Pedro, J., Garcia, P., Laissue, PP., Dobre, GM. and Podoleanu, AG., (2009). Multidimensional en-face OCT imaging of the retina.. Optics Express. 17 (5)

Laissue, PP., Kenwright, C., Hojjat, SA. and Colchester, AC., (2008). Using curve-fitting of curvilinear features for assessing registration of clinical neuropathology with in vivo MRI.. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. 11 (Pt 2)

Laissue, PP. and Vosshall, LB., (2008). Tie olfactory sensory map in Drosophila. BRAIN DEVELOPMENT IN DROSOPHILA MELANOGRASTER. 628

Vosshall, LB. and Laissue, PP., (2008). The olfactory sensory map in drosophila. Advances in Experimental Medicine and Biology. 628

Schmitz, H-P., (2005). From Function to Shape: A Novel Role of a Formin in Morphogenesis of the Fungus Ashbya gossypii. Molecular Biology of the Cell. 17 (1)

Laissue, PP., Reiter, C., Hiesinger, PR., Halter, S., Fischbach, KF. and Stocker, RF., (1999). Three-dimensional reconstruction of the antennal lobe in Drosophila melanogaster. Journal of Comparative Neurology. 405 (4)

Conferences (1)

Jabeen, A., Laissue, PP., Obara, B., Jain, P. and Fernandez, N., (2012). Immunological receptors' expression and communication on extravillous trophoblast cell surface

Grants and funding

2017

A new dynamic for Phosphorus in Riverbed Nitrogen Cycling - PRINCe

Natural Environment Research Council

Bioimaging of dehydroascorbate and (phospho)lipid hydroperoxides: The development of fluorescent protein biosensors

Biotechnology & Biology Science Res.Council

2015

Design specification and prototyping of low-cost lightsheet illumination module for low-phototoxicity fluorescence microscopy

Cairn Research Ltd

Lightsheet illumination modules for low-prototoxicity fluorescence microscopy

The Royal Society

2014

Coral CSR Project Green Light

Nikon UK Ltd

2012

Long-term live cell imaging of reef building corals

The Royal Society

2011

Structural restoration of Rhodopsin ADRP mutants

BRPS

Development of plant-based hydrogen peroxide YFP nanosensors

Biotechnology & Biology Science Res.Council

Contact

plaissue@essex.ac.uk
+44 (0) 1206 872246

Location:

3SW.4.17, Colchester Campus