Aleyna Guney

Postgraduate Research Student
School of Life Sciences
 Aleyna Guney


Ask me about
  • TRAIL, Death receptor signalling
  • Apoptotic Pathways
  • Colorectal cancer


2019-2023 BSc Biomedical Science, University of Essex 2023-2024 MSD Molecular Medicine


  • BSc Biomedical Science University of Essex (2023)

Research and professional activities


The role of TRAIL-R2 signalling in the modulation chemotherapy-induced apoptosis pathways

Supervisor: Dr. Ralf Zwacka

Research interests

Apoptotic signalling pathways

Apoptotic Signaling Pathways in Colorectal Cancer Chemotherapy: I am investigating the mechanisms by which chemotherapy induces programmed cell death (apoptosis) in colorectal cancer. My research focuses on the two major pathways involved in apoptosis: (a) The intrinsic pathway, which is often associated with cellular stress and the role of the p53 tumor suppressor protein. (b) The extrinsic pathway, which involves death receptors such as TRAIL-R1, TRAIL-R2, and their ligand TRAIL.

Role of TRAIL-R2 in Chemotherapy-Induced Apoptosis

TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) is a a pro-apoptotic receptor found on the cell membrane. Since many cancer cells also express membrane death receptors, it presents a promising option for future therapeutic interventions. I am particularly interested in understanding the role of TRAIL-R2 in chemotherapy-induced apoptosis and its potential implications for conventional cancer treatment.



Colchester Campus