Apoptotic signalling pathways
Apoptotic Signaling Pathways in Colorectal Cancer Chemotherapy: I am investigating the mechanisms by which chemotherapy induces programmed cell death (apoptosis) in colorectal cancer. My research focuses on the two major pathways involved in apoptosis: (a) The intrinsic pathway, which is often associated with cellular stress and the role of the p53 tumor suppressor protein.
(b) The extrinsic pathway, which involves death receptors such as TRAIL-R1, TRAIL-R2, and their ligand TRAIL.
Role of TRAIL-R2 in Chemotherapy-Induced Apoptosis
TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) is a a pro-apoptotic receptor found on the cell membrane. Since many cancer cells also express membrane death receptors, it presents a promising option for future therapeutic interventions. I am particularly interested in understanding the role of TRAIL-R2 in chemotherapy-induced apoptosis and its potential implications for conventional cancer treatment.