People

Dr Joaquin De Navascues

Lecturer
School of Life Sciences
Dr Joaquin De Navascues

Research and professional activities

Research interests

Molecular regulation of cell fate decisions

Key words: Gene expression regulation
Open to supervise

Stem cell-based adult tissue homeostasis

Key words: Stem cells
Open to supervise

Late radiation toxicity

Key words: Radiotherapy
Open to supervise

Conferences and presentations

Is the radiosensitivity of fruitflies clinically relevant?

Annual meeting of the Association for Radiation Research, Francis Crick Institute, London, 6/6/2022

Drosophila as a tool for radiobiology

Invited presentation, Drosophila gut meeting, University of Glasgow, Glasgow, 5/5/2022

Modelling late radiation toxicity to normal tissue in Drosophila

Invited presentation, Annual meeting of the Association for Radiation Research, (online), 13/7/2021

Modelling tissue-level responses to radiation in Drosophila

Invited presentation, Annual fly JEDI meeting, University of Essex, Colchester, United Kingdom, 16/9/2019

Teaching and supervision

Current teaching responsibilities

  • Genetics and Evolution (BS102)

  • Transferable Skills in Life Sciences (BS143)

  • Employability Skills for the Biosciences (BS211)

  • Molecular Biology: Genes, Proteins and Disease (BS221)

  • Issues in Biomolecular Science (BS304)

  • Advanced Cancer Biology (BS932)

  • Gene Technology and Synthetic Biology (BS934)

  • Molecular Mechanisms of Disease (BS938)

  • Biomedical Science: Practice and Employability (BS214)

Publications

Journal articles (10)

Guisoni, N., Martinez-Corral, R., Garcia-Ojalvo, J. and de Navascués, J., (2017). Diversity of fate outcomes in cell pairs under lateral inhibition. Development. 144 (7), 1177-1186

Fang, HY., Martinez-Arias, A. and de Navascués, J., (2016). Autocrine and paracrine Wingless signalling in the Drosophila midgut by both continuous gradient and asynchronous bursts of wingless expression. F1000Research. 5, 317-317

Porazinski, S., de Navascués, J., Yako, Y., Hill, W., Jones, MR., Maddison, R., Fujita, Y. and Hogan, C., (2016). EphA2 Drives the Segregation of Ras-Transformed Epithelial Cells from Normal Neighbors. Current Biology. 26 (23), 3220-3229

Jurado, J., de Navascués, J. and Gorfinkiel, N., (2016). α-Catenin stabilises Cadherin–Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction. Journal of Cell Science. 129 (24), 4496-4508

Guisoni, N., Martinez-Corral, R., Garcia Ojalvo, J. and de Navascués, J., (2015). Diversity of fate outcomes in cell pairs under lateral inhibition

de Navascués, J., Perdigoto, CN., Bian, Y., Schneider, MH., Bardin, AJ., Martínez-Arias, A. and Simons, BD., (2012). Drosophilamidgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells. The EMBO Journal. 31 (11), 2473-2485

Muñoz‐Descalzo, S., de Navascues, J. and Arias, AM., (2012). Wnt‐Notch signalling: An integrated mechanism regulating transitions between cell states. BioEssays. 34 (2), 110-118

de Navascués, J. and Modolell, J., (2010). The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila. Mechanisms of Development. 127 (9-12), 393-406

de Navascués, J. and Modolell, J., (2007). tailup, a LIM-HD gene, and Iro-C cooperate inDrosophiladorsal mesothorax specification. Development. 134 (9), 1779-1788

Villa-Cuesta, E., de Navascués, J., Ruiz-Gómez, M., del Corral, RD., Domínguez, M., de Celis, JF. and Modolell, J., (2003). Tufted Is a Gain-of-Function Allele That Promotes Ectopic Expression of the Proneural Gene amos in Drosophila. Genetics. 163 (4), 1403-1412

Grants and funding

2022

Advanced live imaging for the Eastern ARC with dual inverted light-sheets and AI-led analysis

Biotechnology and Biological Sciences Research Council

2021

Acquisition of the Drosophila model system to understand mechanisms of innate immunity regulation by chromatin dynamics

National Centre for the Replacement Refinement & Reduction of Animals in Research

2019

Molecular dynamics of a bHLH transcription factor network in stemness and bi-lineage differentiation in the intestine

The Royal Society

Contact

j.denavascues@essex.ac.uk
+44 (0) 1206 876585

Location:

3SW.3.10, Colchester Campus