Chromatin remodelling and cell fate plasticity during neuronal maturation

  • Thu 10 Mar 22

    13:00 - 14:00

  • Colchester Campus

    STEM 3.1

  • Event speaker

    Tony Southall

  • Event type

    Lectures, talks and seminars

  • Event organiser

    Life Sciences, School of

  • Contact details

    Joaquin De Navascues

Once a neuron has been generated by a mitotic progenitor, it is post-mitotic and will not divide again. Whilst cellular changes during neuronal maturation are well studied, relatively little is known about how the epigenetic state of the genome changes and how these changes relate to the loss of cell fate plasticity during neuronal maturation.

We have identified candidate factors that could be facilitating the ‘locking down’ of neural stem cell genes (NuRD complex (MEP-1) and the condensin complex (Cap-G)).

Knockdown of Cap-G and MEP-1 specifically in neurons (from their birth onwards) results in developmental arrest and dramatic gene expression changes, including aberrant expression of genes that are not normally expressed in the developing brain. Also, both factors show dynamic binding to chromatin during the process of neuronal maturation.

We aim to build on these findings to develop a mechanistic understanding of how the neuronal genome is remodelled to restrict developmental plasticity.


Originally from Malvern, England, Tony has a BSc (Honours) degree in Genetics, a PhD Molecular Genetics and a post-doc in Neural Development. He established his independent research group in 2014 at the Department of Life Sciences, Imperial College London. Here he is a Senior Lecturer and carries out research into: Drosophila neural development; roles of micropeptides; technology development.

How to attend

This seminar is being held in person in STEM 3.1 (STEM Centre on Square 1, Colchester campus). You can also watch via Zoom (meeting ID: 925 4561 0277)

If you have any queries about this seminar please email Dr Joaquin De Navascues (j.denavascues@essex.ac.uk)

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