Conformational disorder in regulation of enzymatic catalysis

  • Thu 3 Mar 22

    14:00 - 15:00

  • Online


  • Event speaker

    Vincenzo Venditti

  • Event type

    Lectures, talks and seminars

  • Event organiser

    Life Sciences, School of

  • Contact details

    Filippo Prischi

Please note that this event is now being held at 2pm.

Enzymes are remarkable nanomachines that play a myriad of essential functions in cellular metabolism.

Modulation of enzyme structure and flexibility by cofactor/substrate binding provides an important source of regulation of enzyme function, yet our understanding of the fundamental mechanisms coupling protein dynamics to enzymatic activity is still largely incomplete.

In the Venditti lab we use NMR combined with other biophysical and biochemical approaches to reveal how the complex interplay between cofactor/substrate binding and conformational dynamics regulates the activity of high molecular weight enzymes that are essential for human and bacterial metabolism. The systems of interest in our research are Enzyme I (EI) of the bacterial phosphotransferase system (PTS), and the human RNA demethylases FTO and Alkbh5.

Our results demonstrate a role for conformational disorder in regulating the activity of these important enzymes and suggest strategies for their selective inhibition.


Vincenzo Venditti received a Ph.D. from the University of Siena in 2009 for his work with Neri Niccolai and Sam Butcher on the surface accessibility of biopolymers.

From 2009 to 2014 he was a Postdoctoral Fellow at the National Institutes of Health in the group of Marius Clore where he specialized in biomolecular NMR techniques for the investigation of protein structure, dynamics and interactions. Vincenzo joined the Department of Chemistry at ISU in January 2015.

How to attend

This seminar is being held on Zoom (meeting ID: 925 4561 0277) only.

If you have any queries about this seminar please email Dr Filippo Prischi (afprischi@essex.ac.uk).

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