Metazoans establish reciprocal interactions with their commensal bacterial communities.
Despite recent progress, a clear view of the physiological benefits associated with host/microbiota relationship remains elusive. Hence the molecular mechanisms through which the microbiota exerts its beneficial influences are still largely undefined.
In this line, we aim at deciphering the molecular dialogue governing the mutualistic interaction between intestinal bacteria and their host. To this end, we are using a genetically tractable gnotobiotic animal model: Drosophila melanogaster, which are associated to its natural dominant commensals, Lactobacillus plantarum and Acetobacter pomorum.
We are developing multiscale functional approaches to identify the mechanisms that underlie their mutualistic relationship, which results in the promotion of host juvenile growth. Our approaches aim at identifying both the bacterial and host genetic and metabolic networks required to sustain their mutualistic relationship.
In addition, we are translating our discoveries to mouse gnotobiotic and conventional models by studying the impact of selected strains or synthetic communities of intestinal bacteria on mice linear growth. Dr Leulier will present the latest results using Drosophila and Mouse models.
François Leulier is a geneticist by training. In 2003 he obtained his PhD under the supervision of Prof. Bruno Lemaitre at the CNRS "Centre de Génétique Moléculaire" in Gif-sur-Yvette where he studied the genetic basis of host resistance mechanisms to bacterial infections using Drosophila as a model host. He joined the CNRS in 2007 as a staff scientist in the lab of Prof. Bruno Lemaitre before moving to the lab of Prof. Julien Royet in the IBDML in Marseille. In those laboratories he followed his studies on the mechanisms underlying host resistance to bacterial infections.
In 2011, he showed that intestinal Lactobacilli promote systemic growth in juvenile Drosophila and he was appointed by the FINOVI foundation in summer 2012 to set up a research group at the "Institut de Génomique Fonctionnelle de Lyon (IGFL)" to develop his research on deciphering the mechanisms underlying the beneficial properties of intestinal Lactobacilli on their host biology using Drosophila and Mice as host models.
Since Jan 2021 he is the Director of the Institut de Génomique Fonctionnelle de Lyon a joint research unit of the Ecole Normale Supérieure de Lyon, CNRS and Université Claude Bernard Lyon-I."
This seminar is being held on Zoom (meeting ID: 925 4561 0277) only.
If you have any queries about this seminar please email Dr Joaquin De Navascues (email@example.com).