Metazoans establish reciprocal interactions with their commensal bacterial communities.
Despite recent progress, a clear view of the physiological benefits associated with host/microbiota relationship remains elusive. Hence the molecular mechanisms through which the microbiota exerts its beneficial influences are still largely undefined.
In this line, we aim at deciphering the molecular dialogue governing the mutualistic interaction between intestinal bacteria and their host. To this end, we are using a genetically tractable gnotobiotic animal model: Drosophila melanogaster, which are associated to its natural dominant commensals, Lactobacillus plantarum and Acetobacter pomorum.
We are developing multiscale functional approaches to identify the mechanisms that underlie their mutualistic relationship, which results in the promotion of host juvenile growth. Our approaches aim at identifying both the bacterial and host genetic and metabolic networks required to sustain their mutualistic relationship.
In addition, we are translating our discoveries to mouse gnotobiotic and conventional models by studying the impact of selected strains or synthetic communities of intestinal bacteria on mice linear growth. Dr Leulier will present the latest results using Drosophila and Mouse models.