We would like to understand how errors in translation impact ageing. In stark contrast to the well-established effect of DNA mutations on multi-cellular organismal ageing and disease, the role of translation errors is far less studied and understood.
Translation errors are rarely investigated in the context of multi-cellular organismal physiology and their effect on ageing of metazoan organisms remains unexplored. We hypothesised that improving fidelity of protein synthesis could be an anti-ageing intervention in multi-cellular organisms.
We investigated the physiological consequences of directly mutating a single evolutionarily conserved residue in the decoding centre of the ribosome and examined for the first time in metazoan species the effect of increased translation fidelity on ageing.
Great interest in the biology of ageing stems from a possibility to improve health in the elderly by mimicking the effect of longevity mutations on organismal physiology through pharmacological approaches. We explore the effect of known anti-ageing drugs on translation fidelity and we also investigate novel screening approaches for pharmacological anti-ageing therapies.
Dr Ivana Bjedov earned a BSc degree in Molecular Biology form University of Zagreb. She did her PhD at the University Pierre and Marie Curie in Paris, in the laboratory of Prof. Miroslav Radman, where she learned about DNA repair in E. coli.
Her interest in ageing research started when she moved to University College London, where she was a postdoctoral EMBO fellow in the laboratory of Prof. Linda Partridge. Her postdoc was focused on understanding how to manipulate the mTOR pathway with rapamycin to improve health and extend lifespan in Drosophila. She joined UCL Cancer Institute upon obtaining ERC Starting Grant and her laboratory is interested in DNA repair and protein synthesis. Recently she became part of the CRUK RadNet City of London network.