Normal gene expression is controlled, in part, through careful coordination of gene regulatory elements, including transcription factors, promoter/enhancer interactions, and 3-dimensional chromatin structure.
The Cohesin complex is essential in maintaining the integrity of local interactions within structurally defined topologically associating domains (TADs) and in influencing dynamic cell-type specific transcriptional programs.
The functional consequences of Cohesin loss of function mutations reveal a link between chromatin architecture and TF activity in hematopoietic lineage commitment and differentiation.
Aaron Viny is Assistant Professor of Medicine, Division of Hematology/Oncology and Department of Genetics & Development at Columbia University. He obtained his BSc in Biopsychology and Cognitive Science in the University of Michigan, then MD/MS in Biomedical Investigation in the Cleveland Clinic Lerner College of Medicine.
Following this, he was an Internal Medicine Intern and Resident in the New York Presbyterian/Weill Cornell Medical College, and later held the hematology and oncology fellowship at the Memorial Sloan Kettering Cancer Center where he was Hematology Chief Fellow and a postdoctoral scientist in the laboratory of Professor Ross Levine. He joined Columbia University as a faculty member in 2020.