Postponed: Many faces of gene regulation

From 3D chromatin organisation to transcription factor binding in Drosophila

  • Thu 23 Apr 20

    13:00 - 14:00

  • Colchester Campus


  • Event speaker

    Dr Radu Zabet (University of Essex)

  • Event type

    Lectures, talks and seminars

  • Event organiser

    Life Sciences, School of

  • Contact details

    Dr Patrick Varga-Weisz

This event has been postponed. We hope to arrange a new date for it in due course.

Compartmentalisation of the genome as topologically associating domains (TADs) was shown to have regulatory role in development and cellular functioning, but the mechanism involved in TAD establishment is still unclear.

We generated the first high-resolution contact map of Drosophila melanogaster neuronal cells (BG3) and identified different classes of TADs by comparing this to the genome 3D organisation in embryonic cells (Kc167).

In particular, we observed changes in genome organisation in differentiated neuronal cells, consisting mainly of enhanced long-range interactions and we show that the rich repertoire of architectural proteins in Drosophila might have a tissue specific role in the chromatin organisation.

Our results indicate that TADs are dynamic across developmental stages and reflect the interplay between architectural proteins, transcriptional states and enhancer activities. 


Dr Radu Zabet is a Lecturer in the School of Life Sciences, University of Essex

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