Synthetic and systems biology of carbon fixation in Chlamydomonas

  • Thu 5 Mar 20

    13:00 - 14:00

  • Colchester Campus

    STEM 3.1

  • Event speaker

    Dr Stephane Lemaire (Institut de Biologie Paris Seine)

  • Event type

    Lectures, talks and seminars

  • Event organiser

    Life Sciences, School of

  • Contact details

    Dr Patrick Varga-Weisz

Redox regulation and signaling play a major role in numerous fundamental cell processes and participate in the mechanisms allowing cells to sense environmental changes and trigger adaptive responses. These regulations and signaling pathways are mainly operated by redox post-translational modifications, such as disulfide bond formation, glutathionylation or nitrosylation, which play a major role at the interface between the environment and the functional proteome.

Using qualitative and quantitative large-scale proteomic approaches in Chlamydomonas reinhardtii, we have unraveled an intricate redox network of more than 1000 proteins regulated by redox post-translational modifications. The results indicate that the Calvin-Benson cycle, responsible for photosynthetic carbon fixation, integrates diverse redox signals since all 11 enzymes of the pathway undergo multiple redox post-translational modifications.

The biochemical, structural and synthetic biology approaches developed to study carbon fixation and its reglation in Chlamydomonas will be presented.

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