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Event

B-FORM DNA: ain’t what it used to be! or Improved understanding of the forces holding the complementary strands together

Wed 3 Apr 19

11:00 - 12:00
Colchester Campus

5S.4.19
Event speaker

Professor Colyn Crane-Robinson (University of Portsmouth)
Event type

Lectures, talks and seminars
Event organiser

Life Sciences, School of
Contact details

Dr Patrick Varga Weisz patrick.varga-weisz@essex.ac.uk
01206 872318

Abstract

The current thermodynamic description of B-form DNA stability is seriously in error in two critical aspects. 1) The enthalpy and entropy of unfolding are shown to be temperature dependent quantities. 2) The greater stabilizing effect of CG pairs does not come from their extra H-bond but from their lower entropy of melting.

A consequence of the new findings is that melting temperature calculations and secondary structure predictions need to use methods quite different from those currently employed.

Speaker

Professor Colyn Crane-Robinson is an Emeritus Professor of the University of Portsmouth.

B-FORM DNA: ain’t what it used to be! or Improved understanding of the forces holding the complementary strands together

Wed 3 Apr 19

Colchester Campus

Event speaker

Event type

Event organiser

Contact details

Abstract

Speaker