Unravelling the logic of gene regulation by distal DNA elements

  • Thu 22 Nov 18

    13:00 - 14:00

  • Colchester Campus

    STEM 3.1

  • Event speaker

    Dr Mikhail Spivakov

  • Event type

    Lectures, talks and seminars
    School of Biological Sciences Seminar Series

  • Event organiser

    Life Sciences, School of

  • Contact details

    Patrick Varga-Weisz
    01206 872318

Unravelling the logic of gene regulation by distal DNA elements

Dr Mikhail Spivakov, Functional Gene Control, MRC London Institute of Medical Sciences

Host: Dr Patrick Varga-Weisz

Three-dimensional chromatin organisation plays a major role in metazoan gene regulation. However, the dynamic nature of genomic architecture across cell types and its effect on lineage commitment are still not fully understood. We have used Promoter-Capture Hi-C to identify distal sequences interacting with the majority of annotated promoters in human cells globally and at high resolution. I will highlight two projects: (1) the analysis of interactome rewiring upon human ES cell commitment, with implications for gene regulation by multiple enhancers and (2) the profiling of promoter interactions in 17 primary haemopoietic cell types and using this information for linking common disease variants with putative target genes and pathways. Taken together, this work demonstrates the power of high-resolution interactome profiling for gaining insights into both global gene regulatory principles and for understanding the mechanisms of specific diseases.

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