2015 - current: Lecturer. University of Essex, School of Biological Sciences
2008 – 2015: German Cancer Research Center (DKFZ) and BioQuant, Heidelberg
2011 – 2015: BIOMS Fellowship
2009 – 2011: Fellow of the Cellnetworks Cluster of Excellence
2008 – 2009: DKFZ Guest Scientist, Group of Prof. Karsten Rippe
2004 – 2008: Belarus National Academy of Sciences, Minsk, Belarus
2009 – 2010: Senior Scientist
2004 – 2008: Research Scientist
VISITING SCIENTIST POSITIONS:
02/2008 – 06/2008: University of California San Diego, (with Prof. Terence Hwa).
10/2007: DKFZ, Boehringer Ingelheim Short-Term Fellowship.
09/2007: International Center of Theoretical Physics, Trieste (UNESCO Fellow).
04/2007 – 05/2007, 11/2005 – 02/2006: Hebrew University, (FEBS Fellow).
2011: BIOMS Fellowship, DKFZ and BioQuant, 2011-2015
2009: German Excellence Cluster Cellnetworks Fellowship
2009: DKFZ Guest Scientist Grant, DKFZ and BioQuant
2008: CTBP Visiting Scientist Grant, University of California at San Diego
2008: SFI Visiting Scientist Grant, Institute of Complex Systems, Santa Fe
2007: Boehringer Ingelheim Short-Term Fellowship, DKFZ
2007: UNESCO Visiting Scientist, International Center of Theoretical Physics
2007: President’s Fellowship (top 100 young scientists of Belarus)
2007: FEBS Short-Term Fellowship, Hebrew University, Jerusalem
2006: Golda Meir Fellowship, Hebrew University, Jerusalem
2004: Fellow of the Belarus National Academy of Sciences, 2004
2002: INTAS Young Scientist Ph.D. Fellowship, CEA/Saclay, France
- Wellcome Trust Seed Award, 2016. “Nucleosome repositioning as a mechanism for cell memory in cancer transitions”, PI. € 112,000.
- @RAction grant, ANR (France), 2015. “Deciphering and modifying epigenetic mechanisms of stem cell development”, PI. € 870,000.
- Merck grant "Chaire Junior Fondagen", 2015, PI. € 275,000
- Sonata-BIS-4 grant, NCN (Poland), 2015, "Predicting differential transcription factor binding in chromatin", PI. € 500,000.
- Intramural Grant of the German Cancer Research Center, 2012-2013, “Calculating transcription factor binding maps in chromatin”, PI. € 120,000.
- Intramural Grant of the German Cancer Research Center, 2012-2013, “Developing a software suite for the analysis of epigenetic regulation from high-throughput sequencing data”, Co-PI, with Yevhen Vainshtein. € 20,000
- Belarus National Foundation of Fundamental Research, Grant #B10M-060, “Investigation of chromatin rearrangements during gene regulation in tumor and normal tissues”, 2010-12, PI.
- Belarusian Governmental Program “Bio-rational Pesticides-II”, “Study of synergistic effects of pesticide combinations using statistical analysis”, 2009-2010, co-PI.
- Belarus National Foundation of Fundamental Research, Grant #B06M-127 “Biomolecular interactions with condensed DNA”, 2006-2008, PI.
- Belarus National Foundation of Fundamental Research, #B02M-091 “Influence of anticancer and carcinogenic metal complexes on DNA condensation”, 2002-2004, PI.
Dr Vladimir Teif (PI)
Dr Graeme Thorn
Dr Svetlana Gretton
Mr Christopher Clarkson
Alumni: Dr Ioanna Pavlaki | Tanvi Sharma | Joshua Burton
We are a small friendly group currently consisting of four members, working on (1) biophysical modelling of epigenetic regulation in chromatin, (2) bioinformatics analysis of high-throughput sequencing data; and (3) sequencing experiments such as ChIP-seq. At the moment we are running several projects devoted to nucleosome positioning, chemical modifications of DNA and histones, and differential binding of proteins in chromatin during stem cell differentiation and cancer transitions.
If you are interested to join us please contact by email with your CV and a short cover letter, indicating how your skills fit to at least one of the directions outlined above.
- Modelling epigenetic regulation
- Next Generation Sequencing
- Biophysics of chromatin
- DNA-protein binding
- Cell differentiation
- Cancer transition
- Lattice models
- BS320 Human Molecular Genetics
- BS222 Genome Science
- BS304 Issues in Biomolecular Science
- BS831 3rd Year Research Projects
- BS984 MSc Molecular Medicine
- BS986 MSc Biotechnology
Advanced Ph.D. lectures:
- Online tools for researchers
- Next Generation Sequencing analysis
Automatically updated list of publications in Google Scholar | Manually updated ORCID profile
- Vainshtein Y., Rippe K. and Teif V.B. (2017). NucTools: analysis of chromatin feature occupancy profiles from high-throughput sequencing data. BMC Genomics 18, 158 | Open access article
- Teif V.B., Mallm J.-P., Sharma T., Mark Welch D.B., Rippe K., Eils R., Langowski J., Olins A.L. and Olins D.E. (2017). Nucleosome repositioning during differentiation of a human myeloid leukemia cell line. Nucleus, in press | Open access article | Preprint
- Teif V.B and Cherstvy A.G. (2016). Chromatin and epigenetics: current biophysical views. AIMS Biophysics 3, 88-98 | Open access article | PDF
- Teif V.B., Kepper N., Yserentant K., Wedemann G., Rippe K. (2015). Affinity, stoichiometry and cooperativity of heterochromatin protein 1 (HP1) binding to nucleosomal arrays. J. Phys.: Condens. Matter 27, 064110 | PDF |
- Salih B., Teif V.B., Tripathi V., Trifonov E.N. (2015) Strong nucleosomes of mouse genome in recovered centromeric sequences. J. Biomol. Struct. Dynam. 33, 1164-1175 | Taylor & Francis Online | PDF |
- Teif V.B., Beshnova D.A., Marth C., Vainshtein Y., Mallm J.-P., Höfer T. and Rippe K. (2014). Nucleosome repositioning links DNA (de)methylation and differential CTCF binding during stem cell development. Genome Research. 24, 1285-1295 | Pubmed | PDF | Press release |
- Beshnova D.A., Cherstvy A.G. Vainshtein Y. and Teif V.B. (2014). Regulation of the nucleosome repeat length in vivo by the DNA sequence, protein concentrations and long-range interactions. PLoS Comp. Biol. 10, e1003698 | PDF |
- Cherstvy A.G. and Teif V.B. (2014). Electrostatic effect of H1-histone protein binding on nucleosome repeat length. Phys. Biol. 11, 044001 | PDF |
- Teif V.B. (2014). On the Sociology of Science 2.0. In "Opening Science: The Evolving Guide on How the Internet is Changing Research, Collaboration and Scholarly Publishing", Eds. S. Bartling, S. Friesike. Springer, 2014, IX, 335 p. 43 illus. | ISBN 978-3-319-00026-8 | Order book online |
- Teif V.B., Erdel F., Beshnova D.A., Vainshtein Y., Mallm J.-P., Rippe K. (2013) Taking into account nucleosomes for predicting gene expression. Methods 62, 26-38 | Sciencedirect | PDF |
- Schöpflin, R., Teif, V. B., Müller, O., Weinberg, C., Rippe, K. & Wedemann, G. (2013). Modeling nucleosome position distributions from experimental nucleosome positioning maps. Bioinformatics. 29, 2380-2386 | Pubmed | Full Text |
- Cherstvy A.G. and Teif V.B. (2013) Structure-driven homology pairing of chromatin fibers: The role of electrostatics and protein bridging. J. Biol. Phys. 39, 363-385 | PDF |
- Teif V.B., Beshnova D., Vainshtein Y., Höfer T., Rippe K. (2013). Developing a software suite to analyze the interplay between nucleosome arrangement, DNA methylation and tanscription factor binding. EMBnet.journal 19A, 39-40. | Abstract | PDF |
- Teif V.B. (2013). Science 3.0: Corrections to the Science 2.0 paradigm. | ArXiv:1301.2522 |
- Teif V. B., Shkrabkou A.V., Egorova V.P., Krot V.I. (2012). Nucleosomes in gene regulation: Theoretical approaches. Molecular Biology 46, 1-10. | PDF |
- Teif V. B. and Rippe K. (2011). Nucleosome mediated crosstalk between transcription factors. Phys. Biol. 8, 04400. | PubMed | PDF |
- Teif V. B. and Bohinc K. (2011). Condensed DNA: condensing the concepts. Progr. Biophys. Mol. Biol. 105, 208-222. | PDF |
- Längst G., Teif V. B. and Rippe K. (2011). Chromatin remodeling by translocation of nucleosomes. In “Genome organization and function in the cell nucleus”, Ed. K. Rippe, Wiley-VCH, Weinheim. P. 111-139. |
- Teif V. B., Ettig R. and Rippe K. (2010). A lattice model for transcription factor access to nucleosomal DNA. Biophys. J. 99, 2597-2607 | PDF |
- Teif V. B. and Rippe K. (2010). Statistical-mechanical lattice models for protein-DNA binding in chromatin. J. Phys.: Condens. Matter. 22, 414105 | PDF |
- Teif V. B., Harries D., Lando D.Y. and Ben-Shaul A. (2010). Matrix formalism for sequence-specific polymer binding to multicomponent lipid membranes. In “Membrane-active peptides: methods and results on structure and function", Ed. M. Castanho, International University Line, La Jolla. | PDF |
2009 and earlier:
- Teif V. B. and Rippe K. (2009). Predicting nucleosome positions on the DNA: combining intrinsic affinities and remodeler activities. Nucleic Acids Res. 37, 5641-5655. | PubMed | PDF | Supplementary Materials |
- Teif V. B., Harries D., Lando D. Y. and Ben-Shaul A. (2008). Matrix formalism for site-specific binding of unstructured proteins to multicomponent lipid membranes. J. Pept. Sci. 14, 368-373. | PubMed | PDF | Supplementary computer program |
- Teif V. B. (2007). General transfer matrix formalism to calculate DNA-protein-drug binding in gene regulation: Application to OR operator of phage lambda. Nucleic Acids Res. 35, e80.
- Teif V. B. (2005). Ligand-induced DNA condensation: choosing the model. Biophys. J. 89, 2574-2587.
- Teif V. B., Lando D. Y. On the cooperativity of metal ion binding to the bases of single-stranded DNA. Europ. J. Biochem. 271(1), 19 (2004). | Abstract
- Teif V. B. (2003). On the cooperativity of metal ion binding to DNA. J. Biomol. Struct. Dynam. 20, 897-898. | Abstract
- Teif V. B. and Lando D. Y. (2003) DNA condensation caused by ligand binding. In “Bioregulators: investigation and application”, Minsk, “Technoprint”. P. 116-128. | PDF (Rus)
- Teif V.B. and Lando D.Y. (2002). Modeling of DNA Condensation and Decondensation Caused by Ligand Binding. J. Biomol Struct Dynam. 20, 215-222. .| PDF | Full Text |
- Teif V. B., Haroutunian S. H., Vorob'ev V. I. and Lando D. Y. (2002) Short-range interactions and size of ligands bound to DNA strongly influence adsorptive phase transition caused by long-range interactions. J. Biomol. Struct. Dynam. 19, 1103-1110.| PDF | Full Text at Taylor & Francis Online |
- Teif V. B. and Lando D. Y. (2001) Calculation of DNA condensation caused by ligand adsorption. Molecular Biology 35, 117-119. | PDF
- Teif V. B. and Lando D. Y. (2001) DNA condensation caused by ligand binding may serve as a sensor. Sensor Technology 2001, ed. M. Elwenspoek, Kluver, Dordrecht, P. 155-160. | PDF
- Teif V. B., Vorob’ev V. I., Lando D. Y. (2001). Calculation of DNA condensation caused by ligand binding using a two-state model. J. Biomol. Struct. Dynam. 18, 908-909. | Abstract |
- Lando D. Y. and Teif V. B. (2000) Long-range interactions between ligands bound to a DNA molecule give rise to adsorption with the character of phase transition of the first kind. J. Biomol. Struct. Dynam. 17, 903-911. | PDF | | Full Text at Taylor & Francis Online |