People

Dr Benjamin Skinner

Lecturer
School of Life Sciences
Dr Benjamin Skinner

Profile

Biography

I'm a biologist interested in structural and evolutionary genomics - how genomes and the chromosomes they contain change and rearrange over time. Currently I'm looking at the shape and organisation of chromatin in asymmetric cell nuclei - for example sperm - which can give information on mechanisms of chromatin packaging during cellular differentiation.

Qualifications

  • PhD in Genetics University of Kent, (2009)

  • BSc (Hons) in Biochemistry University of Kent, (2005)

Appointments

University of Essex

  • Lecturer, School of Life Sciences, University of Essex (1/7/2019 - present)

Other academic

  • Research Associate, Department of Pathology, University of Cambridge (5/8/2009 - 5/7/2019)

Teaching and supervision

Current teaching responsibilities

  • Genetics and Evolution (BS102)

  • Genome Science (BS222)

  • Human Molecular Genetics (BS320)

  • Research Project in Biomolecular Science (BS831)

  • Molecular Mechanisms of Disease (BS938)

Publications

Journal articles (24)

Skinner, BM., Rathje, CC., Bacon, J., Johnson, EEP., Larson, EL., Kopania, EEK., Good, JM., Yousafzai, G., Affara, NA. and Ellis, PJI., (2019). A high-throughput method for unbiased quantitation and categorization of nuclear morphology. Biology of Reproduction. 100 (5), 1250-1260

Skinner, BM., Bacon, J., Rathje, CC., Larson, EL., Kopania, EEK., Good, JM., Affara, NA. and Ellis, PJI., (2019). Automated Nuclear Cartography Reveals Conserved Sperm Chromosome Territory Localization across 2 Million Years of Mouse Evolution. Genes. 10 (2), 109-109

O’Connor, RE., Kiazim, L., Skinner, B., Fonseka, G., Joseph, S., Jennings, R., Larkin, DM. and Griffin, DK., (2019). Patterns of microchromosome organization remain highly conserved throughout avian evolution. Chromosoma. 128 (1), 21-29

Rathje, CC., Johnson, EEP., Drage, D., Patinioti, C., Silvestri, G., Affara, NA., Ialy-Radio, C., Cocquet, J., Skinner, BM. and Ellis, PJI., (2019). Differential Sperm Motility Mediates the Sex Ratio Drive Shaping Mouse Sex Chromosome Evolution. Current Biology. 29 (21), 3692-3698

Rathje, CC., Randle, SJ., Al Rawi, S., Skinner, BM., Nelson, DE., Majumdar, A., Johnson, EEP., Bacon, J., Vlazaki, M., Affara, NA., Ellis, PJ. and Laman, H., (2019). A Conserved Requirement for Fbxo7 During Male Germ Cell Cytoplasmic Remodeling. Frontiers in Physiology. 10

Skinner, BM. and Johnson, EEP., (2017). Nuclear morphologies: their diversity and functional relevance. Chromosoma. 126 (2), 195-212

Osei-Amponsah, R., Skinner, BM., Adjei, DO., Bauer, J., Larson, G., Affara, NA. and Sargent, CA., (2017). Origin and phylogenetic status of the local Ashanti Dwarf pig (ADP) of Ghana based on genetic analysis. BMC Genomics. 18 (1), 193-

Skinner, BM., Sargent, CA., Churcher, C., Hunt, T., Herrero, J., Loveland, JE., Dunn, M., Louzada, S., Fu, B., Chow, W., Gilbert, J., Austin-Guest, S., Beal, K., Carvalho-Silva, D., Cheng, W., Gordon, D., Grafham, D., Hardy, M., Harley, J., Hauser, H., Howden, P., Howe, K., Lachani, K., Ellis, PJI., Kelly, D., Kerry, G., Kerwin, J., Ng, BL., Threadgold, G., Wileman, T., Wood, JMD., Yang, F., Harrow, J., Affara, NA. and Tyler-Smith, C., (2016). The pig X and Y Chromosomes: structure, sequence, and evolution. Genome Research. 26 (1), 130-139

Skinner, BM., Lachani, K., Sargent, CA., Yang, F., Ellis, P., Hunt, T., Fu, B., Louzada, S., Churcher, C., Tyler-Smith, C. and Affara, NA., (2015). Expansion of the HSFY gene family in pig lineages. BMC Genomics. 16 (1), 442-

Quilter, CR., Cooper, WN., Cliffe, KM., Skinner, BM., Prentice, PM., Nelson, L., Bauer, J., Ong, KK., Constância, M., Lowe, WL., Affara, NA. and Dunger, DB., (2014). Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk. The FASEB Journal. 28 (11), 4868-4879

Skinner, BM., Al Mutery, A., Smith, D., Völker, M., Hojjat, N., Raja, S., Trim, S., Houde, P., Boecklen, WJ. and Griffin, DK., (2014). Global patterns of apparent copy number variation in birds revealed by cross-species comparative genomic hybridization. Chromosome Research. 22 (1), 59-70

Lithgow, PE., O’Connor, R., Smith, D., Fonseka, G., Al Mutery, A., Rathje, C., Frodsham, R., O’Brien, P., Kasai, F., Ferguson-Smith, MA., Skinner, BM. and Griffin, DK., (2014). Novel tools for characterising inter and intra chromosomal rearrangements in avian microchromosomes. Chromosome Research. 22 (1), 85-97

Romanov, MN., Farré, M., Lithgow, PE., Fowler, KE., Skinner, BM., O’Connor, R., Fonseka, G., Backström, N., Matsuda, Y., Nishida, C., Houde, P., Jarvis, ED., Ellegren, H., Burt, DW., Larkin, DM. and Griffin, DK., (2014). Reconstruction of gross avian genome structure, organization and evolution suggests that the chicken lineage most closely resembles the dinosaur avian ancestor. BMC Genomics. 15 (1), 1060-1060

Ellis, PJI., Morris, TJ., Skinner, BM., Sargent, CA., Vickers, MH., Gluckman, PD., Gilmour, S. and Affara, NA., (2014). Thrifty metabolic programming in rats is induced by both maternal undernutrition and postnatal leptin treatment, but masked in the presence of both: implications for models of developmental programming. BMC Genomics. 15 (1), 49-49

Skinner, BM., Lachani, K., Sargent, CA. and Affara, NA., (2013). Regions of XY homology in the pig X chromosome and the boundary of the pseudoautosomal region. BMC Genetics. 14 (1), 3-3

Khulan, B., Cooper, WN., Skinner, BM., Bauer, J., Owens, S., Prentice, AM., Belteki, G., Constancia, M., Dunger, D. and Affara, NA., (2012). Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in the Gambia. Human Molecular Genetics. 21 (9), 2086-2101

Skinner, BM. and Griffin, DK., (2012). Intrachromosomal rearrangements in avian genome evolution: evidence for regions prone to breakpoints. Heredity. 108 (1), 37-41

Volker, M., Backstrom, N., Skinner, BM., Langley, EJ., Bunzey, SK., Ellegren, H. and Griffin, DK., (2010). Copy number variation, chromosome rearrangement, and their association with recombination during avian evolution. Genome Research. 20 (4), 503-511

Warren, WC., Clayton, DF., Ellegren, H., Arnold, AP., Hillier, LW., Künstner, A., Searle, S., White, S., Vilella, AJ., Fairley, S., Heger, A., Kong, L., Ponting, CP., Jarvis, ED., Mello, CV., Minx, P., Lovell, P., Velho, TAF., Ferris, M., Balakrishnan, CN., Sinha, S., Blatti, C., London, SE., Li, Y., Lin, Y-C., George, J., Sweedler, J., Southey, B., Gunaratne, P., Watson, M., Nam, K., Backström, N., Smeds, L., Nabholz, B., Itoh, Y., Whitney, O., Pfenning, AR., Howard, J., Völker, M., Skinner, BM., Griffin, DK., Ye, L., McLaren, WM., Flicek, P., Quesada, V., Velasco, G., Lopez-Otin, C., Puente, XS., Olender, T., Lancet, D., Smit, AFA., Hubley, R., Konkel, MK., Walker, JA., Batzer, MA., Gu, W., Pollock, DD., Chen, L., Cheng, Z., Eichler, EE., Stapley, J., Slate, J., Ekblom, R., Birkhead, T., Burke, T., Burt, D., Scharff, C., Adam, I., Richard, H., Sultan, M., Soldatov, A., Lehrach, H., Edwards, SV., Yang, S-P., Li, X., Graves, T., Fulton, L., Nelson, J., Chinwalla, A., Hou, S., Mardis, ER. and Wilson, RK., (2010). The genome of a songbird. Nature. 464 (7289), 757-762

Skinner, BM., Völker, M., Ellis, M. and Griffin, DK., (2009). An Appraisal of Nuclear Organisation in Interphase Embryonic Fibroblasts of Chicken, Turkey and Duck. Cytogenetic and Genome Research. 126 (1-2), 156-164

Skinner, BM., Robertson, LBW., Tempest, HG., Langley, EJ., Ioannou, D., Fowler, KE., Crooijmans, RPMA., Hall, AD., Griffin, DK. and Völker, M., (2009). Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysis. BMC Genomics. 10 (1), 357-357

Ioannou, D., Tempest, HG., Skinner, BM., Thornhill, AR., Ellis, M. and Griffin, DK., (2009). Quantum dots as new-generation fluorochromes for FISH: an appraisal. Chromosome Research. 17 (4), 519-530

Griffin, DK., Robertson, LBW., Tempest, HG. and Skinner, BM., (2007). The evolution of the avian genome as revealed by comparative molecular cytogenetics. Cytogenetic and Genome Research. 117 (1-4), 64-77

Morris, WB., Stephenson, JE., Robertson, LBW., Turner, K., Brown, H., Ioannou, D., Tempest, HG., Skinner, BM. and Griffin, DK., (2007). Practicable approaches to facilitate rapid and accurate molecular cytogenetic mapping in birds and mammals. Cytogenetic and Genome Research. 117 (1-4), 36-42

Conferences (20)

Johnson, EEP., Skinner, BM., Ellis, PJL. and Affara, NA., (2016). Sex Ratio Distortion in a Y Chromosome Deletion Model

Skinner, BM., Johnson, EEP., Rathje, CC. and Ellis, PJI., (2016). Nuclear Morphology and Fertility in Mouse Sperm

Ellis, PJI., Rathje, CC., Mills, BP., Yousafzai, G., Silvestri, G., Stewart, V., Larson, EL., Good, JM. and Skinner, BM., (2016). Quantitative Morphometric Analysis as a Tool for Investigating the Evolution of Sperm Morphology and Nuclear Organisation in Mouse

Lithgow, PE., O'Connor, RE., Smith, D., Fonseka, G., Al Mutery, A., Rathje, C., Frodsham, R., O'Brien, P., Ferguson-Smith, MA., Skinner, BM. and Griffin, DK., (2015). Inter and intra chromosomal rearrangements in avian microchromosomes

Romanov, MN., Farre, M., Lithgow, PE., O'Connor, R., Fowler, KE., Skinner, BM., Larkin, DM. and Griffin, DK., (2015). Avian ancestral karyotype reconstruction and differential rates of inter-and intra-chromosomal change in different lineages

Skinner, BM., Ellis, PJI., Johnson, EE. and Affara, NA., (2015). Mapping chromosome positions with 'sperm cartography'

Johnson, EEP., Skinner, BM., Ellis, PJI. and Affara, NA., (2015). Investigating physiological and molecular mechanisms of sex ratio distortion

Skinner, BM., Sargent, CA., Yang, F., Lachani, K., Fu, B., Ellis, PJI., Pereira, SLG., Churcher, C., Tyler-Smith, C., Affara, NA. and Grp, PXYS., (2015). A first generation sequence assembly of the pig Y chromosome

Griffin, DK., Voelker, ME., Trim, SA. and Skinner, BM., (2010). Avian "Chromonomics" the bird genome from the chromosome's point of view

Voelker, M., Skinner, BM., Langley, EJ., Bunzey, SK., Gera, C. and Griffin, DK., (2009). How conserved are bird genomes? Insights from the chicken and zebra finch genome projects

Skinner, BM., Robertson, LBW., Tempest, HG., Langley, EJ., Ioannou, D., Fowler, KE., Crooijmans, RPMA., Hall, AD., Griffin, DK. and Voelker, ME., (2009). Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysis

Skinner, BM., Voelker, M., Al Mutery, A. and Griffin, DK., (2009). An overview of copy number variation in birds

Ioannou, D., Tempest, HG., Skinner, BM., Thornhill, AR., Ellis, M. and Griffin, DK., (2009). Quantum dots as new-generation fluorochromes for FISH: an appraisal

Skinner, BM., Voelker, M., Ellis, M. and Griffin, DK., (2009). A detailed appraisal of nuclear organization in chicken embryonic fibroblasts and comparative genomics in turkey and duck

Volker, M., Skinner, BM., Tempest, HG. and Griffin, DK., (2008). Evolution of the avian genome as revealed by molecular cytogenetics

Skinner, BM., Volker, M., Fonseka, GL., Ellis, M. and Griffin, DK., (2008). Nuclear (genome) organisation and comparative genomics in birds

Fonseka, GL., Ioannou, D., Skinner, BM., Ellis, M. and Griffin, DK., (2008). Manual vs. automated methods to assess nuclear organisation

Fowler, KE., Skinner, BM., Robertson, LBW., Tempest, HG., Volker, M. and Griffin, DK., (2008). Molecular cytogenetic maps of turkey, duck and zebra finch and their implications for genome evolution

Morris, W., Stephenson, J., Robertson, L., Turner, K., Brown, H., Ioannou, D., Tempest, H., Skinner, B. and Griffin, D., (2007). Computer based learning approaches to facilitate rapid and accurate molecular cytogenetic mapping in birds and mammals

Cheng, R., Finch, K., Skinner, B. and Griffin, D., (2007). Sperm aneuploidy screening in ICSI males: To automate or not to automate

Reports and Papers (1)

Skinner, BM., Bacon, J., Rathje, CC., Larson, EL., Kopania, EEK., Good, JM., Affara, NA. and Ellis, PJI., (2019). Automated nuclear cartography reveals conserved sperm chromosome territory localization across 2 million years of mouse evolution

Contact

b.skinner@essex.ac.uk
+44 (0) 1206 874868

Location:

3SW.6.18, Colchester Campus