People

Professor Leonard Schalkwyk

Professor
School of Biological Sciences
Professor Leonard Schalkwyk
  • Email

  • Telephone

    +44 (0) 1206 873322

  • Location

    3SW.6.16, Colchester Campus

Profile

Biography

Originally a microbiologist from Canada, Leo studied at the University of Alberta, graduating in 1983. His PhD (Dalhousie University, 1991) was on genome mapping of Haloferax, an archaeon from the Dead Sea. He worked on genomic resources for several species and genome mapping of mouse in Hans Lehrachs laboratory at the Imperial Cancer Research Fund laboratory in London and at the Max-Planck-Institut für molekulare Genetik in Berlin. He was at the Social, Genetic and Developmental Psychiatry Research Centre, Kings College London from 2000-2014, where he worked on functional genomics and epigenomics, identifying genes involved in behaviour in the mouse and in depression, schizophrenia and Alzheimers disease in human. His research program is now widening to include environmental epigenetics ResearcherID, PhD Student:Tyler Gorrie-Stone MSD Student:Alexandria Andrayas

Qualifications

  • 1991 PhD in Biochemistry, Dalhousie University. Studies on the structure of the genome of Haloferax volcanii

  • 1983 BSc in Microbiology, University of Alberta

Appointments

University of Essex

  • Professor of Human Genetics, School of Biological Sciences, University of Essex ( 1/10/2014 - present )

Other academic

  • Visiting Professor, SGDP, Institute of Psychiatry, Psychology and Neuroscience King's College London ( 1/10/2014 - present )

  • Reader in Functional Genomics, SGDP, Institute of Psychiatry King's College London ( 1/1/2004 - 30/9/2014 )

  • Senior Lecturer in Molecular Genetics, SGDP, Institute of Psychiatry King's College London ( 1/4/2000 - 31/12/2018 )

Research and professional activities

Research interests

Genomic and epigenomic methods and software

Epigenomics and the environment

Alzheimers disease

Schizophrenia

Current research

DNA methylation profiles in human blood and brain, methods and software for epigenomic studies.

postdoctoral fellow: Dr Louis El Khoury

Teaching and supervision

  • Enterprise and Employability for the Biosciences (BS211)

  • Genome Science (BS222)

  • Computational Data Analysis: R for Life Sciences (BS231)

  • Issues in Biomolecular Science (BS304)

  • Issues in Biomedical Science (BS306)

  • Human Molecular Genetics (BS320)

  • Practical Skills in Cancer Research (BS933)

Publications

Journals (187)

Smith, RG., Hannon, E., De Jager, PL., Chibnik, L., Lott, SJ., Condliffe, D., Smith, AR., Haroutunian, V., Troakes, C., Al-Sarraj, S., Bennett, DA., Powell, J., Lovestone, S., Schalkwyk, L., Mill, J. and Lunnon, K., (2018). Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimer's and Dementia

Janecka, M., Mill, J., Basson, MA., Goriely, A., Spiers, H., Reichenberg, A., Schalkwyk, L. and Fernandes, C., (2017). Advanced paternal age effects in neurodevelopmental disorders—review of potential underlying mechanisms. Translational Psychiatry. 7 (1)

Janecka, M., Marzi, SJ., Parsons, MJ., Liu, L., Paya-Cano, JL., Smith, RG., Fernandes, C. and Schalkwyk, LC., (2017). Genetic polymorphisms and their association with brain and behavioural measures in heterogeneous stock mice. Scientific Reports. 7

Malki, K., Tosto, MG., Mouriño-Talín, H., Rodríguez-Lorenzo, S., Pain, O., Jumhaboy, I., Liu, T., Parpas, P., Newman, S., Malykh, A., Carboni, L., Uher, R., McGuffin, P., Schalkwyk, LC., Bryson, K. and Herbster, M., (2017). Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 174 (3)

Janecka, M., Haworth, CM., Ronald, A., Krapohl, E., Happé, F., Mill, J., Schalkwyk, LC., Fernandes, C., Reichenberg, A. and Rijsdijk, F., (2017). Paternal Age Alters Social Development in Offspring. Journal of the American Academy of Child & Adolescent Psychiatry. 56 (5)

Lunnon, K., Keohane, A., Pidsley, R., Newhouse, S., Riddoch-Contreras, J., Thubron, EB., Devall, M., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Schalkwyk, L., Dobson, R., Malik, AN., Powell, J., Lovestone, S. and Hodges, A., (2017). Mitochondrial genes are altered in blood early in Alzheimer's disease. Neurobiology of Aging. 53

Viana, J., Hannon, E., Dempster, E., Pidsley, R., Macdonald, R., Knox, O., Spiers, H., Troakes, C., Al-Saraj, S., Turecki, G., Schalkwyk, LC. and Mill, J., (2017). Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Human Molecular Genetics. 26 (1)

Devall, M., Smith, RG., Jeffries, A., Hannon, E., Davies, MN., Schalkwyk, L., Mill, J., Weedon, M. and Lunnon, K., (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clinical Epigenetics. 9 (1)

Rutten, BPF., Vermetten, E., Vinkers, CH., Ursini, G., Daskalakis, NP., Pishva, E., de Nijs, L., Houtepen, LC., Eijssen, L., Jaffe, AE., Kenis, G., Viechtbauer, W., van den Hove, D., Schraut, KG., Lesch, K-P., Kleinman, JE., Hyde, TM., Weinberger, DR., Schalkwyk, L., Lunnon, K., Mill, J., Cohen, H., Yehuda, R., Baker, DG., Maihofer, AX., Nievergelt, CM., Geuze, E. and Boks, MPM., (2017). Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder. Molecular Psychiatry

Janecka, M., Marzi, SJ., Parsons, MJ., Liu, L., Paya-Cano, JL., Smith, RG., Fernandes, C. and Schalkwyk, LC., (2017). Genetic polymorphisms and their association with brain and behavioural measures in heterogeneous stock mice. Scientific Reports. 7

Janecka, M., Mill, J., Basson, MA., Goriely, A., Spiers, H., Reichenberg, A., Schalkwyk, LC. and Fernandes, C., (2017). Advanced paternal age effects in neurodevelopmental disorders?review of potential underlying mechanisms. Translational Psychiatry. 7

Viana, J., Hannon, E., Dempster, E., Pidsley, R., Macdonald, R., Knox, O., Spiers, H., Troakes, C., Al-Saraj, S., Turecki, G., Schalkwyk, LC. and Mill, J., (2017). Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Human Molecular Genetics

Spiers, H., Hannon, E., Schalkwyk, LC., Bray, NJ. and Mill, J., (2017). 5-hydroxymethylcytosine is highly dynamic across human fetal brain development. BMC Genomics. 18 (1)

Smith, AR., Smith, RG., Condliffe, D., Hannon, E., Schalkwyk, L., Mill, J. and Lunnon, K., (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiology of Aging. 47

Marzi, SJ., Meaburn, EL., Dempster, EL., Lunnon, K., Paya-Cano, JL., Smith, RG., Volta, M., Troakes, C., Schalkwyk, LC. and Mill, J., (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics. 11 (1)

Carter, KW., Carter, K., Francis, R., Bresnahan, M., Gissler, M., Grønborg, T., Gross, R., Gunnes, N., Hammond, G., Hornig, M., Hultman, C., Huttunen, J., Langridge, A., Leonard, H., Newman, S., Parner, E., Petersson, G., Reichenberg, A., Sandin, S., Schendel, D., Schalkwyk, L., Sourander, A., Steadman, C., Stoltenberg, C., Suominen, A., Surén, P., Susser, E., Sylvester Vethanayagam, A. and Yusof, Z., (2016). ViPAR: a software platform for the Virtual Pooling and Analysis of Research Data. International Journal of Epidemiology. 45 (2)

Hannon, E., Dempster, E., Viana, J., Burrage, J., Smith, AR., Macdonald, R., St Clair, D., Mustard, C., Breen, G., Therman, S., Kaprio, J., Toulopoulou, T., Pol, HEH., Bohlken, MM., Kahn, RS., Nenadic, I., Hultman, CM., Murray, RM., Collier, DA., Bass, N., Gurling, H., McQuillin, A., Schalkwyk, L. and Mill, J., (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biology. 17 (1)

Lunnon, K., Hannon, E., G.Smith, R., Dempster, E., Wong, C., Burrage, J., Troakes, C., Al-Sarraj, S., Kepa, A., Schalkwyk, L. and Mill, J., (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biology. 17 (1)

Malki, K., Du Rietz, E., Crusio, WE., Pain, O., Paya-Cano, J., Karadaghi, RL., Sluyter, F., de Boer, SF., Sandnabba, K., Schalkwyk, LC., Asherson, P. and Tosto, MG., (2016). Transcriptome analysis of genes and gene networks involved in aggressive behavior in mouse and zebrafish. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 171 (6)

Houtepen, LC., Vinkers, CH., Carrillo-Roa, T., Hiemstra, M., van Lier, PA., Meeus, W., Branje, S., Heim, CM., Nemeroff, CB., Mill, J., Schalkwyk, LC., Creyghton, MP., Kahn, RS., Joëls, M., Binder, EB. and Boks, MPM., (2016). Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nature Communications. 7

Malki, K., Tosto, MG., Pain, O., Sluyter, F., Mineur, YS., Crusio, WE., de Boer, S., Sandnabba, KN., Kesserwani, J., Robinson, E., Schalkwyk, LC. and Asherson, P., (2016). Comparative mRNA analysis of behavioral and genetic mouse models of aggression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 171 (3)

Lunnon, K., Hannon, E., Smith, RG., Dempster, E., Wong, C., Burrage, J., Troakes, C., Al-Sarraj, S., Kepa, A., Schalkwyk, L. and Mill, J., (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biology. 17 (1)

Malki, K., Tosto, MG., Pain, O., Sluyter, F., Mineur, YS., Crusio, WE., de Boer, S., Sandnabba, KN., Kesserwani, J., Robinson, E., Schalkwyk, LC. and Asherson, P., (2016). Comparative mRNA analysis of behavioral and genetic mouse models of aggression. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 171 (3)

Houtepen, LC., Vinkers, CH., Carrillo-Roa, T., Hiemstra, M., van Lier, PA., Meeus, W., Branje, S., Heim, CM., Nemeroff, CB., Mill, J., Schalkwyk, LC., Creyghton, MP., Kahn, RS., Jo�ls, M., Binder, EB. and Boks, MPM., (2016). Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nature Communications. 7

Malki, K., Mineur, YS., Tosto, MG., Campbell, J., Karia, P., Jumabhoy, I., Sluyter, F., Crusio, WE. and Schalkwyk, LC., (2015). Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains. BMC Genomics. 16 (1)

Martin, C., Tansey, KE., Schalkwyk, LC. and Powell, TR., (2015). The inflammatory cytokines: molecular biomarkers for major depressive disorder?. Biomarkers in Medicine. 9 (2)

Boks, MP., Mierlo, HCV., Rutten, BP., Radstake, TR., De Witte, L., Geuze, E., Horvath, S., Schalkwyk, LC., Vinkers, CH., Broen, JC. and Vermetten, E., (2015). Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder. Psychoneuroendocrinology. 51

Elliott, G., Hong, C., Xing, X., Zhou, X., Li, D., Coarfa, C., Bell, RJ., Maire, CL., Ligon, KL., Sigaroudinia, M., Gascard, P., Tlsty, TD., Harris, RA., Schalkwyk, LC., Bilenky, M., Mill, J., Farnham, PJ., Kellis, M., Marra, MA., Milosavljevic, A., Hirst, M., Stormo, GD., Wang, T. and Costello, JF., (2015). Intermediate DNA methylation is a conserved signature of genome regulation. Nature Communications. 6

Spiers, H., Hannon, E., Schalkwyk, LC., Smith, R., Wong, CC., O’Donovan, MC., Bray, NJ. and Mill, J., (2015). Methylomic trajectories across human fetal brain development. Genome Research. 25 (3)

Hannon, E., Spiers, H., Viana, J., Pidsley, R., Burrage, J., Murphy, TM., Troakes, C., Turecki, G., O'Donovan, MC., Schalkwyk, LC., Bray, NJ. and Mill, J., (2015). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nature Neuroscience. 19 (1)

Janecka, M., Manduca, A., Servadio, M., Trezza, V., Smith, R., Mill, J., Schalkwyk, LC., Reichenberg, A. and Fernandes, C., (2015). Effects of advanced paternal age on trajectories of social behavior in offspring. Genes, Brain and Behavior. 14 (6)

Hannon, E., Lunnon, K., Schalkwyk, L. and Mill, J., (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics. 10 (11)

Malki, K., Pain, O., Tosto, MG., Du Rietz, E., Carboni, L. and Schalkwyk, LC., (2015). Identification of genes and gene pathways associated with major depressive disorder by integrative brain analysis of rat and human prefrontal cortex transcriptomes. Translational Psychiatry. 5 (3)

Malki, K., Pain, O., Tosto, MG., Du Rietz, E., Carboni, L. and Schalkwyk, LC., (2015). Identification of genes and gene pathways associated with major depressive disorder by integrative brain analysis of rat and human prefrontal cortex transcriptomes. Translational Psychiatry. 5 (3)

Elliott, G., Hong, C., Xing, X., Zhou, X., Li, D., Coarfa, C., Bell, RJA., Maire, CL., Ligon, KL., Sigaroudinia, M., Gascard, P., Tlsty, TD., Harris, RA., Schalkwyk, LC., Bilenky, M., Mill, J., Farnham, PJ., Kellis, M., Marra, MA., Milosavljevic, A., Hirst, M., Stormo, GD., Wang, T. and Costello, JF., (2015). Intermediate DNA methylation is a conserved signature of genome regulation. Nature Communications. 6

Smith, RG., Fernandes, C., Kember, R., Schalkwyk, LC., Buxbaum, J., Reichenberg, A. and Mill, J., (2014). Transcriptomic changes in the frontal cortex associated with paternal age. Molecular Autism. 5 (1)

Viana, J., Pidsley, R., Troakes, C., Spiers, H., Wong, CC., Al-Sarraj, S., Craig, I., Schalkwyk, L. and Mill, J., (2014). Epigenomic and transcriptomic signatures of a Klinefelter syndrome (47,XXY) karyotype in the brain. Epigenetics. 9 (4)

Punapart, M., Eltermaa, M., Oflijan, J., Sütt, S., Must, A., Kõks, S., Schalkwyk, LC., Fernandes, C., Vasar, E., Soomets, U. and Terasmaa, A., (2014). Effect of Chronic Valproic Acid Treatment on Hepatic Gene Expression Profile in Wfs1 Knockout Mouse. PPAR Research. 2014

Powell, TR., Powell-Smith, G., Haddley, K., Mcguffin, P., Quinn, J., Schalkwyk, LC., Farmer, AE. and D'Souza, UM., (2014). Mood-stabilizers differentially affect housekeeping gene expression in human cells. International Journal of Methods in Psychiatric Research. 23 (2)

Powell, TR., McGuffin, P., D'Souza, UM., Cohen-Woods, S., Hosang, GM., Martin, C., Matthews, K., Day, RK., Farmer, AE., Tansey, KE. and Schalkwyk, LC., (2014). Putative Transcriptomic Biomarkers in the Inflammatory Cytokine Pathway Differentiate Major Depressive Disorder Patients from Control Subjects and Bipolar Disorder Patients. PLoS ONE. 9 (3)

Malki, K., Pain, O., Du Rietz, E., Tosto, MG., Paya-Cano, J., Sandnabba, KN., de Boer, S., Schalkwyk, LC. and Sluyter, F., (2014). Genes and Gene Networks Implicated in Aggression Related Behaviour. neurogenetics. 15 (4)

Lunnon, K., Smith, R., Hannon, E., De Jager, PL., Srivastava, G., Volta, M., Troakes, C., Al-Sarraj, S., Burrage, J., Macdonald, R., Condliffe, D., Harries, LW., Katsel, P., Haroutunian, V., Kaminsky, Z., Joachim, C., Powell, J., Lovestone, S., Bennett, DA., Schalkwyk, LC. and Mill, J., (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nature Neuroscience. 17 (9)

Ilott, NE., Schneider, T., Mill, J., Schalkwyk, L., Brolese, G., Bizarro, L., Stolerman, IP., Dempster, E. and Asherson, P., (2014). Long-Term Effects of Gestational Nicotine Exposure and Food-Restriction on Gene Expression in the Striatum of Adolescent Rats. PLoS ONE. 9 (2)

Malki, K., Keers, R., Tosto, MG., Lourdusamy, A., Carboni, L., Domenici, E., Uher, R., McGuffin, P. and Schalkwyk, LC., (2014). The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder. BMC Medicine. 12 (1)

Condliffe, D., Wong, A., Troakes, C., Proitsi, P., Patel, Y., Chouliaras, L., Fernandes, C., Cooper, J., Lovestone, S., Schalkwyk, L., Mill, J. and Lunnon, K., (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiology of Aging. 35 (8)

Bell, J., Loomis, A., Butcher, L., Gao, F., Zhang, B., Hyde, C., Sun, J., Wu, H., Ward, K., Harris, J., Scollen, S., Davies, M., Schalkwyk, L., Mill, J., Ahmadi, KR., Ainali, C., Barrett, A., Bataille, V., Bell, JT., Buil, A., Deloukas, P., Dermitzakis, ET., Dimas, AS., Durbin, R., Glass, D., Grundberg, E., Hassanali, N., Hedman, AK., Ingle, C., Knowles, D., Krestyaninova, M., Lindgren, CM., Lowe, CE., McCarthy, MI., Meduri, E., di Meglio, P., Min, JL., Montgomery, SB., Nestle, FO., Nica, AC., Nisbet, J., O’Rahilly, S., Parts, L., Potter, S., Sekowska, M., Shin, S-Y., Small, KS., Soranzo, N., Spector, TD., Surdulescu, G., Travers, ME., Tsaprouni, L., Tsoka, S., Wilk, A., Yang, T-P., Zondervan, KT., Williams, F., Li, N., Deloukas, P., Beck, S., McMahon, S., Wang, J., John, S. and Spector, T., (2014). Differential methylation of the TRPA1 promoter in pain sensitivity. Nature Communications. 5

De Jager, PL., Srivastava, G., Lunnon, K., Burgess, J., Schalkwyk, LC., Yu, L., Eaton, ML., Keenan, BT., Ernst, J., McCabe, C., Tang, A., Raj, T., Replogle, J., Brodeur, W., Gabriel, S., Chai, HS., Younkin, C., Younkin, SG., Zou, F., Szyf, M., Epstein, CB., Schneider, JA., Bernstein, BE., Meissner, A., Ertekin-Taner, N., Chibnik, LB., Kellis, M., Mill, J. and Bennett, DA., (2014). Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nature Neuroscience. 17 (9)

Wong, CCY., Meaburn, EL., Ronald, A., Price, TS., Jeffries, AR., Schalkwyk, LC., Plomin, R. and Mill, J., (2014). Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Molecular Psychiatry. 19 (4)

Pidsley, R., Viana, J., Hannon, E., Spiers, H., Troakes, C., Al-Saraj, S., Mechawar, N., Turecki, G., Schalkwyk, LC., Bray, NJ. and Mill, J., (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. Genome Biology. 15 (10)

Davis, OSP., Band, G., Pirinen, M., Haworth, CMA., Meaburn, EL., Kovas, Y., Harlaar, N., Docherty, SJ., Hanscombe, KB., Trzaskowski, M., Curtis, CJC., Strange, A., Freeman, C., Bellenguez, C., Su, Z., Pearson, R., Vukcevic, D., Langford, C., Deloukas, P., Hunt, S., Gray, E., Dronov, S., Potter, SC., Tashakkori-Ghanbaria, A., Edkins, S., Bumpstead, SJ., Blackwell, JM., Bramon, E., Brown, MA., Casas, JP., Corvin, A., Duncanson, A., Jankowski, JAZ., Markus, HS., Mathew, CG., Palmer, CNA., Rautanen, A., Sawcer, SJ., Trembath, RC., Viswanathan, AC., Wood, NW., Barroso, I., Peltonen, L., Dale, PS., Petrill, SA., Schalkwyk, LS., Craig, IW., Lewis, CM., Price, TS., Donnelly, P., Plomin, R. and Spencer, CCA., (2014). The correlation between reading and mathematics ability at age twelve has a substantial genetic component. Nature Communications. 5

Tarantino, LM. and Schalkwyk, LC., (2014). Introduction to mammalian genome special issue: genetics of behavior. Mammalian Genome. 25 (1-2)

Pidsley, R., Viana, J., Hannon, E., Spiers, HH., Troakes, C., Al-Saraj, S., Mechawar, N., Turecki, G., Schalkwyk, LC., Bray, NJ. and Mill, J., (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. Genome Biology. 15 (10)

Bell, JT., Loomis, AK., Butcher, LM., Gao, F., Zhang, B., Hyde, CL., Sun, J., Wu, H., Ward, K., Harris, J., Scollen, S., Davies, MN., Schalkwyk, LC., Mill, J., Williams, FMK., Li, N., Deloukas, P., Beck, S., McMahon, SB., Wang, J., John, SL. and Spector, TD., (2014). Differential methylation of the TRPA1 promoter in pain sensitivity. Nature Communications. 5

Punapart, M., Eltermaa, M., Oflijan, J., S�tt, S., Must, A., K�ks, S., Schalkwyk, LC., Fernandes, C., Vasar, E., Soomets, U. and Terasmaa, A., (2014). Effect of chronic valproic Acid treatment on hepatic gene expression profile in wfs1 knockout mouse. PPAR Research. 2014

Ilott, NE., Schneider, T., Mill, J., Schalkwyk, LC., Brolese, G., Bizarro, L., Stolerman, IP., Dempster, E. and Asherson, P., (2014). Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats. PloS One. 9 (2)

Powell, TR., McGuffin, P., D'Souza, UM., Cohen-Woods, S., Hosang, GM., Martin, C., Matthews, K., Day, RK., Farmer, AE., Tansey, KE. and Schalkwyk, LC., (2014). Putative transcriptomic biomarkers in the inflammatory cytokine pathway differentiate major depressive disorder patients from control subjects and bipolar disorder patients. PloS One. 9 (3)

Smith, RG., Fernandes, C., Kember, R., Schalkwyk, LC., Buxbaum, J., Reichenberg, A. and Mill, J., (2014). Transcriptomic changes in the frontal cortex associated with paternal age. Molecular Autism. 5 (1)

Davis, OSP., Band, G., Pirinen, M., Haworth, CMA., Meaburn, EL., Kovas, Y., Harlaar, N., Docherty, SJ., Hanscombe, KB., Trzaskowski, M., Curtis, CJC., Strange, A., Freeman, C., Bellenguez, C., Su, Z., Pearson, R., Vukcevic, D., Langford, C., Deloukas, P., Hunt, S., Gray, E., Dronov, S., Potter, SC., Tashakkori-Ghanbaria, A., Edkins, S., Bumpstead, SJ., Blackwell, JM., Bramon, E., Brown, MA., Casas, JP., Corvin, A., Duncanson, A., Jankowski, JAZ., Markus, HS., Mathew, CG., Palmer, CNA., Rautanen, A., Sawcer, SJ., Trembath, RC., Viswanathan, AC., Wood, NW., Barroso, I., Peltonen, L., Dale, PS., Petrill, SA., Schalkwyk, LC., Craig, IW., Lewis, CM., Price, TS., Donnelly, P., Plomin, R. and Spencer, CCA., (2014). The correlation between reading and mathematics ability at age twelve has a substantial genetic component. Nature Communications. 5

Malki, K., Keers, R., Tosto, MG., Lourdusamy, A., Carboni, L., Domenici, E., Uher, R., McGuffin, P. and Schalkwyk, LC., (2014). The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder. BMC Medicine. 12

Pidsley, R., Y Wong, CC., Volta, M., Lunnon, K., Mill, J. and Schalkwyk, LC., (2013). A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics. 14 (1)

Powell, TR., Tansey, KE., Breen, G., Farmer, AE., Craig, IW., Uher, R., McGuffin, P., D’Souza, UM. and Schalkwyk, LC., (2013). ATP-binding cassette sub-family F member 1 (ABCF1) is identified as a putative therapeutic target of escitalopram in the inflammatory cytokine pathway. Journal of Psychopharmacology. 27 (7)

Powell, TR., Smith, RG., Hackinger, S., Schalkwyk, LC., Uher, R., McGuffin, P., Mill, J. and Tansey, KE., (2013). DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP. Translational Psychiatry. 3 (9)

Malki, K., Tosto, MG., Jumabhoy, I., Lourdusamy, A., Sluyter, F., Craig, I., Uher, R., McGuffin, P. and Schalkwyk, LC., (2013). Integrative mouse and human mRNA studies using WGCNA nominates novel candidate genes involved in the pathogenesis of major depressive disorder. Pharmacogenomics. 14 (16)

Lill, M., Kõks, S., Soomets, U., Schalkwyk, LC., Fernandes, C., Lutsar, I. and Taba, P., (2013). Peripheral blood RNA gene expression profiling in patients with bacterial meningitis. Frontiers in Neuroscience. 7 (7)

Koks, S., Overall, RW., Ivask, M., Soomets, U., Guha, M., Vasar, E., Fernandes, C. and Schalkwyk, LC., (2013). Silencing of the WFS1 gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage. Physiological Genomics. 45 (5)

Navarrete, K., Pedroso, I., De Jong, S., Stefansson, H., Steinberg, S., Stefansson, K., Ophoff, RA., Schalkwyk, LC. and Collier, DA., (2013). TCF4 ( e2-2; ITF2 ): A schizophrenia-associated gene with pleiotropic effects on human disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 162 (1)

Powell, TR., Schalkwyk, LC., Heffernan, AL., Breen, G., Lawrence, T., Price, T., Farmer, AE., Aitchison, KJ., Craig, IW., Danese, A., Lewis, C., McGuffin, P., Uher, R., Tansey, KE. and D'Souza, UM., (2013). Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response. European Neuropsychopharmacology. 23 (9)

Smith, RG., Reichenberg, A., Kember, RL., Buxbaum, JD., Schalkwyk, LC., Fernandes, C. and Mill, J., (2013). Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease. Molecular Psychiatry. 18 (6)

Powell, TR., Smith, RG., Hackinger, S., Schalkwyk, LC., Uher, R., McGuffin, P., Mill, J. and Tansey, KE., (2013). DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP. Translational Psychiatry. 3

Lill, M., K�ks, S., Soomets, U., Schalkwyk, LC., Fernandes, C., Lutsar, I. and Taba, P., (2013). Peripheral blood RNA gene expression profiling in patients with bacterial meningitis. Frontiers in Neuroscience. 7

Navarrete, K., Pedroso, I., De Jong, S., Stefansson, H., Steinberg, S., Stefansson, K., Ophoff, RA., Schalkwyk, LC. and Collier, DA., (2013). TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 162 (1)

Pidsley, R., Wong, CCY., Volta, M., Lunnon, K., Mill, J. and Schalkwyk, LC., (2013). A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics. 14

Malki, K., Lourdusamy, A., Binder, E., Payá-Cano, J., Sluyter, F., Craig, I., Keers, R., McGuffin, P., Uher, R. and Schalkwyk, LC., (2012). Antidepressant-dependent mRNA changes in mouse associated with hippocampal neurogenesis in a mouse model of depression. Pharmacogenetics and Genomics. 22 (11)

Pidsley, R., Fernandes, C., Viana, J., Paya-Cano, JL., Liu, L., Smith, RG., Schalkwyk, LC. and Mill, J., (2012). DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice. Molecular Brain. 5 (1)

Davies, MN., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, RA., Milosavljevic, A., Troakes, C., Al-Sarraj, S., Dobson, R., Schalkwyk, LC. and Mill, J., (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biology. 13 (6)

Parsons, MJ., Grimm, C., Paya-Cano, JL., Fernandes, C., Liu, L., Philip, VM., Chesler, EJ., Nietfeld, W., Lehrach, H. and Schalkwyk, LC., (2012). Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains. BMC Genomics. 13 (1)

Malki, K., Campbell, J., Davies, M., Keers, R., Uher, R., Ward, M., Paya-Cano, J., Aitchinson, KJ., Binder, E., Sluyter, F., Kuhn, K., Selzer, S., Craig, I., McGuffin, P. and Schalkwyk, LC., (2012). Pharmacoproteomic investigation into antidepressant response in two mouse inbred strains. PROTEOMICS. 12 (14)

Keers, R., Pedroso, I., Breen, G., Aitchison, KJ., Nolan, PM., Cichon, S., Nöthen, MM., Rietschel, M., Schalkwyk, LC. and Fernandes, C., (2012). Reduced Anxiety and Depression-Like Behaviours in the Circadian Period Mutant Mouse Afterhours. PLoS ONE. 7 (6)

Jeffries, AR., Perfect, LW., Ledderose, J., Schalkwyk, LC., Bray, NJ., Mill, J. and Price, J., (2012). Stochastic Choice of Allelic Expression in Human Neural Stem Cells. STEM CELLS. 30 (9)

Kember, RL., Dempster, EL., Lee, THA., Schalkwyk, LC., Mill, J. and Fernandes, C., (2012). Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to Nr3c1 , Avp , and Nr4a1 in mouse. Brain and Behavior. 2 (4)

Pidsley, R., Fernandes, C., Viana, J., Paya-Cano, JL., Liu, L., Smith, RG., Schalkwyk, LC. and Mill, J., (2012). DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice. Molecular Brain. 5

Davies, MN., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, RA., Milosavljevic, A., Troakes, C., Al-Sarraj, S., Dobson, R., Schalkwyk, LC. and Mill, J., (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biology. 13 (6)

Parsons, MJ., Grimm, C., Paya-Cano, J., Fernandes, C., Liu, L., Philip, VM., Chesler, EJ., Nietfeld, W., Lehrach, H. and Schalkwyk, LC., (2012). Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains. BMC Genomics. 13

Keers, R., Pedroso, I., Breen, G., Aitchison, KJ., Nolan, PM., Cichon, S., Nothen, MM., Rietschel, M., Schalkwyk, LC. and Fernandes, C., (2012). Reduced Anxiety and Depression-Like Behaviours in the Circadian Period Mutant Mouse Afterhours. PloS One. 7 (6)

Binder, E., Malki, K., Paya-Cano, JL., Fernandes, C., Aitchison, KJ., Mathé, AA., Sluyter, F. and Schalkwyk, LC., (2011). Antidepressants and the resilience to early-life stress in inbred mouse strains. Pharmacogenetics and Genomics. 21 (12)

Malki, K., Uher, R., Paya-Cano, J., Binder, E., Rietschel, M., Zobel, A., Mors, O., Hauser, J., Henigsberg, N., Jerman, B., Souery, D., Placentino, A., Ng, MY., Cohen-Woods, S., Sluyter, F., Farmer, A., Aitchison, KJ., Craig, IW., Lewis, CM., McGuffin, P. and Schalkwyk, LC., (2011). Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants. Biological Psychiatry. 69 (4)

Dempster, EL., Pidsley, R., Schalkwyk, LC., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., Murray, RM. and Mill, J., (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Human Molecular Genetics. 20 (24)

Koks, S., Soomets, U., Plaas, M., Terasmaa, A., Noormets, K., Tillmann, V., Vasar, E., Fernandes, C. and Schalkwyk, LC., (2011). Hypothalamic gene expression profile indicates a reduction in G protein signaling in the Wfs1 mutant mice. Physiological Genomics. 43 (24)

Sikk, K., (2011). Peripheral blood RNA expression profiling in illicit methcathinone users reveals effect on immune system. Frontiers in Genetics. 2 (AUG)

Kember, RL., Fernandes, C., Tunbridge, EM., Liu, L., Payá-Cano, JL., Parsons, MJ. and Schalkwyk, LC., (2010). A B2 SINE insertion in the Comt1 gene (Comt1B2i) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains. Genes, Brain and Behavior. 9 (8)

Davis, OSP., Butcher, LM., Docherty, SJ., Meaburn, EL., Curtis, CJC., Simpson, MA., Schalkwyk, LC. and Plomin, R., (2010). A Three-Stage Genome-Wide Association Study of General Cognitive Ability: Hunting the Small Effects. Behavior Genetics. 40 (6)

Docherty, SJ., Davis, OSP., Kovas, Y., Meaburn, EL., Dale, PS., Petrill, SA., Schalkwyk, LC. and Plomin, R., (2010). A genome-wide association study identifies multiple loci associated with mathematics ability and disability. Genes, Brain and Behavior. 9 (2)

Schalkwyk, LC., Meaburn, EL., Smith, R., Dempster, EL., Jeffries, AR., Davies, MN., Plomin, R. and Mill, J., (2010). Allelic Skewing of DNA Methylation Is Widespread across the Genome. The American Journal of Human Genetics. 86 (2)

Lad, HV., Liu, L., Paya-Cano, JL., Parsons, MJ., Kember, R., Fernandes, C. and Schalkwyk, LC., (2010). Behavioural battery testing: Evaluation and behavioural outcomes in 8 inbred mouse strains. Physiology & Behavior. 99 (3)

Davies, MN., Meaburn, EL. and Schalkwyk, LC., (2010). Gene set enrichment; a problem of pathways. Briefings in Functional Genomics. 9 (5-6)

Kõks, S., Velthut, A., Sarapik, A., Altmäe, S., Reinmaa, E., Schalkwyk, L., Fernandes, C., Lad, H., Soomets, U., Jaakma, Ü. and Salumets, A., (2010). The differential transcriptome and ontology profiles of floating and cumulus granulosa cells in stimulated human antral follicles. MHR: Basic science of reproductive medicine. 16 (4)

Schosser, A., Pirlo, K., Gaysina, D., Cohen-Woods, S., Schalkwyk, LC., Elkin, A., Korszun, A., Gunasinghe, C., Gray, J., Jones, L., Meaburn, E., Farmer, AE., Craig, IW. and McGuffin, P., (2010). Utility of the pooling approach as applied to whole genome association scans with high-density Affymetrix microarrays. BMC Research Notes. 3 (1)

Ronald, A., Butcher, LM., Docherty, S., Davis, OSP., Schalkwyk, LC., Craig, IW. and Plomin, R., (2010). A Genome-Wide Association Study of Social and Non-Social Autistic-Like Traits in the General Population Using Pooled DNA, 500 K SNP Microarrays and Both Community and Diagnosed Autism Replication Samples. Behavior Genetics. 40 (1)

Meaburn, EL., Schalkwyk, LC. and Mill, J., (2010). Allele-specific methylation in the human genome. Epigenetics. 5 (7)

Ronald, A., Butcher, LM., Docherty, SJ., Davis, OSP., Schalkwyk, LC., Craig, IW. and Plomin, R., (2010). Response to comment by Stuart Macgregor. Behavior Genetics. 40 (1)

Sikk, K., K�ks, S., Soomets, U., Schalkwyk, LC., Fernandes, C., Haldre, S., Aquilonius, SM. and Taba, P., (2010). Peripheral blood RNA gene expression profiling in illicit methcathinone users reveals effect on immune system. Movement Disorders. 25 (S2)

Smith, RG., Kember, RL., Mill, J., Fernandes, C., Schalkwyk, LC., Buxbaum, JD. and Reichenberg, A., (2009). Advancing Paternal Age Is Associated with Deficits in Social and Exploratory Behaviors in the Offspring: A Mouse Model. PLoS ONE. 4 (12)

Meaburn, EL., Fernandes, C., Craig, IW., Plomin, R. and Schalkwyk, LC., (2009). Assessing Individual Differences in Genome-Wide Gene Expression in Human Whole Blood: Reliability Over Four Hours and Stability Over 10 Months. Twin Research and Human Genetics. 12 (04)

Kas, MJ., Gelegen, C., Schalkwyk, LC. and Collier, DA., (2009). Interspecies comparisons of functional genetic variations and their implications in neuropsychiatry. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 150B (3)

Davis, OSP., Plomin, R. and Schalkwyk, LC., (2009). The SNPMaP package for R: a framework for genome-wide association using DNA pooling on microarrays. Bioinformatics. 25 (2)

Koks, S., Soomets, U., Paya-Cano, JL., Fernandes, C., Luuk, H., Plaas, M., Terasmaa, A., Tillmann, V., Noormets, K., Vasar, E. and Schalkwyk, LC., (2009). Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway. Physiological Genomics. 37 (3)

Overall, R., (2009). Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Frontiers in Neuroscience. 3 (NOV)

Davies, M., (2009). To what extent is blood a reasonable surrogate for brain in gene expression studies: estimation from mouse hippocampus and spleen. Frontiers in Neuroscience. 1 (OCT)

Meaburn, EL., Fernandes, C., Craig, IW., Plomin, R. and Schalkwyk, LC., (2009). Assessing Individual Differences in Genome-Wide Gene Expression in Human Whole Blood: Reliability Over Four Hours and Stability Over 10 Months. Twin Research and Human Genetics. 12 (4)

Kas, MJH., Gelegen, C., Schalkwyk, LC. and Collier, DA., (2009). Interspecies Comparisons of Functional Genetic Variations and Their Implications in Neuropsychiatry. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 150B (3)

Kõks, S., Fernandes, C., Kurrikoff, K., Vasar, E. and Schalkwyk, LC., (2008). Gene expression profiling reveals upregulation of Tlr4 receptors in Cckb receptor deficient mice. Behavioural Brain Research. 188 (1)

Meaburn, EL., Harlaar, N., Craig, IW., Schalkwyk, LC. and Plomin, R., (2008). Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children. Molecular Psychiatry. 13 (7)

Parsons, MJ., Grimm, CH., Paya-Cano, JL., Sugden, K., Nietfeld, W., Lehrach, H. and Schalkwyk, LC., (2008). Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function. Mammalian Genome. 19 (7-8)

Kas, MJH., Fernandes, C., Schalkwyk, LC. and Collier, DA., (2007). Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men. Molecular Psychiatry. 12 (4)

Schalkwyk, LC., Fernandes, C., Nash, MW., Kurrikoff, K., Vasar, E. and Kõks, S., (2007). Interpretation of knockout experiments: the congenic footprint. Genes, Brain and Behavior. 6 (3)

Caspi, A., Williams, B., Kim-Cohen, J., Craig, IW., Milne, BJ., Poulton, R., Schalkwyk, LC., Taylor, A., Werts, H. and Moffitt, TE., (2007). Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proceedings of the National Academy of Sciences. 104 (47)

Plomin, R. and Schalkwyk, LC., (2007). Microarrays. Developmental Science. 10 (1)

Lad, HV., Liu, L., Payá-Cano, JL., Fernandes, C. and Schalkwyk, LC., (2007). Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping. Mammalian Genome. 18 (6-7)

Docherty, SJ., Butcher, LM., Schalkwyk, LC. and Plomin, R., (2007). Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies. BMC Genomics. 8 (1)

Sugden, K., D'Souza, U., Aitchison, K., Schalkwyk, L., McGuffin, P., Byers, H., Campbell, J., Hye, A. and Pariante, C., (2007). P.1.31 Gene expression analyses of mouse fibroblast cell line L929 after antidepressant treatment. European Neuropsychopharmacology. 17

Docherty, SJ., Butcher, LM., Schalkwyk, LC. and Plomin, R., (2007). Applicability of DNA pools on 500 KSNP microarrays for cost-effective initial screens in genomewide association studies. BMC Genomics. 8

Meaburn, E., (2006). Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans. Nucleic Acids Research. 34 (4)

Fernandes, C., Hoyle, E., Dempster, E., Schalkwyk, LC. and Collier, DA., (2006). Performance deficit of α7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes, Brain and Behavior. 5 (6)

D'Souza, U., Sugden, K., Aitchison, K., Schalkwyk, L., McGuffin, P. and Pariante, M., (2006). S.16.02 Depression: the GENDEP study. European Neuropsychopharmacology. 16

D'Souza, UM., Sugden, K., Pariante, CM., Byers, H., Ward, M., Schalkwyk, LC., McGuffin, P. and Aitchison, KJ., (2006). Effects of antidepressant treatment on gene expression in mouse cultured cells. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 141B (7)

Meaburn, EL., Butcher, LM., Schalkwyk, LC. and Plomin, R., (2006). Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans. Nucleic acids research. 34 (4)

Butcher, LM., Meaburn, EL., Craig, IW., Schalkwyk, LC. and Plomin, R., (2006). A genomewide association scan for GE interplay in childhood. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 141B (7)

Galsworthy, MJ., Paya-Cano, JL., Liu, L., Monleón, S., Gregoryan, G., Fernandes, C., Schalkwyk, LC. and Plomin, R., (2005). Assessing Reliability, Heritability and General Cognitive Ability in a Battery of Cognitive Tasks for Laboratory Mice. Behavior Genetics. 35 (5)

Butcher, LM., Meaburn, E., Knight, J., Sham, PC., Schalkwyk, LC., Craig, IW. and Plomin, R., (2005). SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children. Human Molecular Genetics. 14 (10)

Butcher, LM., Meaburn, E., Dale, PS., Sham, P., Schalkwyk, LC., Craig, IW. and Plomin, R., (2005). Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single-nucleotide polymorphisms. Molecular Psychiatry. 10 (4)

Simpson, CL., (2005). A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays. Nucleic Acids Research. 33 (3)

Meaburn, E., Butcher, LM., Liu, L., Fernandes, C., Hansen, V., Al-Chalabi, A., Plomin, R., Craig, I. and Schalkwyk, LC., (2005). Genotyping DNA pools on microarrays: Tackling the QTL problem of large samples and large numbers of SNPs. BMC Genomics. 6

Butcher, LM., Meaburn, E., Knight, J., Sham, PC., Schalkwyk, LC., Craig, IW. and Plomin, R., (2005). SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children. HUMAN MOLECULAR GENETICS. 14 (10)

Meaburn, EL., Butcher, LM., Liu, L., Fernandes, C., Hansen, V., Al-Chalabi, A., Plomin, R., Craig, IW. and Schalkwyk, LC., (2005). Genotyping DNA pools on microarrays: Tackling the QTL problem of large samples and large numbers of SNPs. BMC Genomics. 6

Simpson, CL., Knight, J., Butcher, LM., Hansen, VK., Meaburn, EL., Schalkwyk, LC., Craig, IW., Powell, JF., Sham, PC. and Al-Chalabi, A., (2005). A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays. Nucleic acids research. 33 (3)

Fernandes, C., Liu, L., Paya-Cano, JL., Gregorov�, S., Forejt, J. and Schalkwyk, LC., (2004). Behavioral Characterization of Wild Derived Male Mice (Mus musculus musculus) of the PWD/Ph Inbred Strain: High Exploration Compared to C57BL/6J. Behavior Genetics. 34 (6)

Nyberg, J., Sandnabba, K., Schalkwyk, L. and Sluyter, F., (2004). Genetic and environmental (inter)actions in male mouse lines selected for aggressive and nonaggressive behavior. Genes, Brain and Behavior. 3 (2)

Butcher, LM., Meaburn, E., Liu, L., Fernandes, C., Hill, L., Al-Chalabi, A., Plomin, R., Schalkwyk, L. and Craig, IW., (2004). Genotyping Pooled DNA on Microarrays: A Systematic Genome Screen of Thousands of SNPs in Large Samples to Detect QTLs for Complex Traits. Behavior Genetics. 34 (5)

Stolerman, I., Chamberlain, S., Bizarro, L., Fernandes, C. and Schalkwyk, L., (2004). The role of nicotinic receptor α7 subunits in nicotine discrimination. Neuropharmacology. 46 (3)

Churchill, GA., Airey, DC., Allayee, H., Angel, JM., Attie, AD., Beatty, J., Beavis, WD., Belknap, JK., Bennett, B., Berrettini, W., Bleich, A., Bogue, M., Broman, KW., Buck, KJ., Buckler, E., Burmeister, M., Chesler, EJ., Cheverud, JM., Clapcote, S., Cook, MN., Cox, RD., Crabbe, JC., Crusio, WE., Darvasi, A., Deschepper, CF., Doerge, RW., Farber, CR., Forejt, J., Gaile, D., Garlow, SJ., Geiger, H., Gershenfeld, H., Gordon, T., Gu, J., Gu, W., de Haan, G., Hayes, NL., Heller, C., Himmelbauer, H., Hitzemann, R., Hunter, K., Hsu, H-C., Iraqi, FA., Ivandic, B., Jacob, HJ., Jansen, RC., Jepsen, KJ., Johnson, DK., Johnson, TE., Kempermann, G., Kendziorski, C., Kotb, M., Kooy, RF., Llamas, B., Lammert, F., Lassalle, J-M., Lowenstein, PR., Lu, L., Lusis, A., Manly, KF., Marcucio, R., Matthews, D., Medrano, JF., Miller, DR., Mittleman, G., Mock, BA., Mogil, JS., Montagutelli, X., Morahan, G., Morris, DG., Mott, R., Nadeau, JH., Nagase, H., Nowakowski, RS., O'Hara, BF., Osadchuk, AV., Page, GP., Paigen, B., Paigen, K., Palmer, AA., Pan, H-J., Peltonen-Palotie, L., Peirce, J., Pomp, D., Pravenec, M., Prows, DR., Qi, Z., Reeves, RH., Roder, J., Rosen, GD., Schadt, EE., Schalkwyk, LC., Seltzer, Z., Shimomura, K., Shou, S., Sillanpää, MJ., Siracusa, LD., Snoeck, H-W., Spearow, JL., Svenson, K., Tarantino, LM., Threadgill, D., Toth, LA., Valdar, W., de Villena, FP-M., Warden, C., Whatley, S., Williams, RW., Wiltshire, T., Yi, N., Zhang, D., Zhang, M. and Zou, F., (2004). The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics. 36 (11)

Ben Abdelkhalek, H., (2004). The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes & Development. 18 (14)

Fernandes, C., Paya-Cano, JL., Sluyter, F., D'Souza, U., Plomin, R. and Schalkwyk, LC., (2004). Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behaviour. European Journal of Neuroscience. 19 (9)

Craig, IW., Mill, J., Craig, GM., Loat, C. and Schalkwyk, LC., (2004). Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes. European Journal of Human Genetics. 12 (8)

The Complex Trait Consortium, (2003). Guidelines: The nature and identification of quantitative trait loci: a community's view. Nature Reviews Genetics. 4 (11)

Sluyter, F. and Schalkwyk, LC., (2003). Aggression across species. Behavior Genetics. 33 (5)

Mill, J., Galsworthy, MJ., Paya-Cano, JL., Sluyter, F., Schalkwyk, LC., Plomin, R. and Asherson, P., (2002). Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activity. Genes, Brain and Behavior. 1 (3)

Klose, J., Nock, C., Herrmann, M., Stühler, K., Marcus, K., Blüggel, M., Krause, E., Schalkwyk, LC., Rastan, S., Brown, SD., Büssow, K., Himmelbauer, H. and Lehrach, H., (2002). Genetic analysis of the mouse brain proteome. Nature Genetics. 30 (4)

Tandon, K., Schalkwyk, LC., Checkley, S., Patel, M., Kinirons, M., Kerwin, RW., McGuffin, P. and Aitchison, KJ., (2002). CYP2D6 genotype and treatment with tricyclic antidepressants. American Journal of Medical Genetics. 114 (7)

Schalkwyk, LC., (2001). Advanced Integrated Mouse YAC Map Including BAC Framework. Genome Research. 11 (12)

Ryu, S., Cho, S., Park, S., Lim, W., Kim, M., Hong, S., Bae, D., Park, Y., Kim, B., Kim, H. and Yun, H., (2001). Cloning of the cel 9A gene and characterization of its gene product from marine bacterium Pseudomonas sp. SK38. Applied Microbiology and Biotechnology. 57 (1-2)

Leong, WL., Dobson, MJ., Logsdon, Jr., JM., Abdel-Majid, RM., Schalkwyk, LC., Guernsey, DL. and Neumann, PE., (2000). ETn insertion in the mouse Adcy1 gene: transcriptional and phylogenetic analyses. Mammalian Genome. 11 (2)

Gösele, C., Hong, L., Kreitler, T., Rossmann, M., Hieke, B., Groß, U., Kramer, M., Himmelbauer, H., Bihoreau, M-T., Kwitek-Black, AE., Twigger, S., Tonellato, PJ., Jacob, HJ., Schalkwyk, LC., Lindpaintner, K., Ganten, D., Lehrach, H. and Knoblauch, M., (2000). High-Throughput Scanning of the Rat Genome Using Interspersed Repetitive Sequence-PCR Markers. Genomics. 69 (3)

Knoblauch, M., Gösele, C., Zimdahl, H., Hieke, B., Himmelbauer, H., Schalkwyk, L., Lindpaintner, K., Ganten, D. and Lehrach, H., (2000). New tools for the high throughput characterization of rat genomic DNA samples. Journal of Experimental Animal Science. 41 (1-2)

Himmelbauer, H., (2000). Interspersed repetitive sequence (IRS)-PCR for typing of whole genome radiation hybrid panels. Nucleic Acids Research. 28 (2)

Zhu, B., Smith, JA., Tracey, SM., Konfortov, BA., Welzel, K., Schalkwyk, LC., Lehrach, H., Kollers, S., Masabanda, J., Buitkamp, J., Fries, R., Williams, JL. and Miller, JR., (1999). A 5× genome coverage bovine BAC library: production, characterization, and distribution. Mammalian Genome. 10 (7)

Hills, D., Tracey, S., Masabanda, J., Fries, R., Schalkwyk, LC., Lehrach, H., Miller, JR. and Williams, JL., (1999). A bovine YAC library containing four- to five-fold genome equivalents. Mammalian Genome. 10 (8)

Nock, C., Gauss, C., Schalkwyk, LC., Klose, J., Lehrach, H. and Himmelbauer, H., (1999). Technology development at the interface of proteome research and genomics: Mapping nonpolymorphic proteins on the physical map of mouse chromosomes. Electrophoresis. 20 (4-5)

Nock, C., Gauss, C., Schalkwyk, LC., Klose, J., Lehrach, H. and Himmelbauer, H., (1999). Technology development at the interface of proteome research and genomics: Mapping nonpolymorphic proteins on the physical map of mouse chromosomes. Electrophoresis. 20 (4-5)

Schalkwyk, LC., (1999). Panel of Microsatellite Markers for Whole-Genome Scans and Radiation Hybrid Mapping and a Mouse Family Tree. Genome Research. 9 (9)

Schalkwyk, LC., Himmelbauer, H. and Lehrach, H., (1999). Toward the mammalian transcript map. Archiv fur Tierzucht. 42 (6 SUPPL.)

Buitkamp, J., Ewald, D., Schalkwyk, L., Weiher, M., Masabanda, J., Sazanov, A., Lehrach, H. and Fries, R., (1998). Construction and characterisation of a gridded chicken cosmid library with four-fold genomic coverage. Animal Genetics. 29 (4)

Priestley, A., (1998). Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20. Nucleic Acids Research. 26 (8)

Schalkwyk, LC., Weiher, M., Kirby, M., Cusack, B., Himmelbauer, H. and Lehrach, H., (1998). Refined radiation hybrid map of mouse Chromosome 17. Mammalian Genome. 9 (10)

Himmelbauer, H., Wedemeyer, N., Haaf, T., Wanker, EE., Schalkwyk, LC. and Lehrach, H., (1998). IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse Chromosome 5. Mammalian Genome. 9 (1)

Himmelbauer, H., Dunkel, I., Otto, GW., Burgtorf, C., Schalkwyk, LC. and Lehrach, H., (1998). Complex probes for high-throughput parallel genetic mapping of genomic mouse BAC clones. Mammalian Genome. 9 (8)

Abdel-Majid, RM., Leong, WL., Schalkwyk, LC., Smallman, DS., Wong, ST., Storm, DR., Fine, A., Dobson, MJ., Guernsey, DL. and Neumann, PE., (1998). Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex. Nature Genetics. 19 (3)

Toye, AA., Schalkwyk, L., Lehrach, H. and Bumstead, N., (1997). A yeast artificial chromosome (YAC) library containing 10 haploid chicken genome equivalents. Mammalian Genome. 8 (4)

Crnogorac-Jurcevic, T., Brown, J., Lehrach, H. and Schalkwyk, L., (1997). Tetraodon fluviatilis,a New Puffer Fish Model for Genome Studies. Genomics. 41 (2)

Cai, L., Schalkwyk, LC., Schoeberlein-Stehli, A., Zee, RY., Smith, A., Haaf, T., Georges, M., Lehrach, H. and Lindpaintner, K., (1997). Construction and Characterization of a 10-Genome Equivalent Yeast Artificial Chromosome Library for the Laboratory Rat,Rattus norvegicus. Genomics. 39 (3)

Hunter, KW., Riba, L., Schalkwyk, L., Clark, M., Resenchuk, S., Beeghly, A., Su, J., Tinkov, F., Lee, P., Ramu, E., Lehrach, H. and Housman, D., (1996). Toward the construction of integrated physical and genetic maps of the mouse genome using interspersed repetitive sequence PCR (IRS-PCR) genomics.. Genome Research. 6 (4)

McCarthy, L., Hunter, K., Schalkwyk, L., Riba, L., Anson, S., Mott, R., Newell, W., Bruley, C., Bar, I. and Ramu, E., (1995). Efficient high-resolution genetic mapping of mouse interspersed repetitive sequence PCR products, toward integrated genetic and physical mapping of the mouse genome.. Proceedings of the National Academy of Sciences. 92 (12)

Schalkwyk, LC., Francis, F. and Lehrach, H., (1995). Techniques in mammalian genome mapping. Current Opinion in Biotechnology. 6 (1)

Breen, M., Deakln, L., Macdonald, B., Miller, S., Sibson, R., Tarttelln, E., Avner, P., Bourgade, F., Guenet, J-L., Montagutelli, X., Polrier, C., Simon, D., Tailor, D., Bishop, M., Kelly, M., Rysavy, F., Rastan, S., Norris, D., Shepherd, D., Abbott, C., Pllz, A., Hodge, S., Jackson, I., Boyd, Y., Blair, H., Maslen, G., A.Todd, J., W.Reed, P., Stoye, J., Ashworth, A., McCarthy, L., Cox, R., Schalkwyk, L., Lehrach, H., Klose, J., Gangadharan, U. and Brown, S., (1994). Towards high resolution maps of the mouse and human genomes—a facility for ordering markers to 0.1 cM resolution. Human Molecular Genetics. 3 (4)

A.Jones, K., M.Black, D., A.Brown, M., L.Griffiths, B., M.Nicolai, H., A.Chambers, J., Bonjardim, M., Xu, C-F., Boyd, M., MeFariane, R., Korn, B., Poustka, A., A.North, M., Schalkwyk, L., Lehrach, H. and Solomon, E., (1994). The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase. Human Molecular Genetics. 3 (11)

Jones, JE., Huckaby, CS., Stafford, MD. and Linnoila, RI., (1994). An MspI RFLP of the human AHR gene.. Human molecular genetics. 3 (11)

BREEN, M., DEAKIN, L., MACDONALD, B., MILLER, S., SIBSON, R., TARTTELIN, E., AVNER, P., BOURGADE, F., GUENET, JL., MONTAGUTELLI, X., POIRIER, C., SIMON, D., TAILOR, D., BISHOP, M., KELLY, M., RYSAVY, F., RASTAN, S., NORRIS, D., SHEPHERD, D., ABBOTT, C., PILZ, A., HODGE, S., JACKSON, I., BOYD, Y., BLAIR, H., MASLEN, G., TODD, JA., REED, PW., STOYE, J., ASHWORTH, A., MCCARTHY, L., COX, R., SCHALKWYK, L., LEHRACH, H., KLOSE, J., GANGADHARAN, U. and BROWN, S., (1994). TOWARDS HIGH-RESOLUTION MAPS OF THE MOUSE AND HUMAN GENOMES - A FACILITY FOR ORDERING MARKERS TO 0.1 CM RESOLUTION (VOL 3, PG 621, 1994). HUMAN MOLECULAR GENETICS. 3 (5)

Breen, M., Deakin, L., Macdonald, B., Miller, S., Sibson, R., Tarttelin, E., Avner, P., Bourgade, F., Guenet, JL., Montagutelli, X., Poirier, C., Simon, D., Tailor, D., Bishop, M., Kelly, M., Rysavy, F., Rastan, S., Norris, D., Shepherd, D., Abbott, C., Pilz, A., Hodge, S., Jackson, I., Boyd, Y., Blair, H., Maslen, G., Todd, JA., Reed, PW., Stoye, J., Ashworth, A., McCarthy, L., Cox, R., Schalkwyk, LC., Lehrach, H., Klose, J., Gangadharan, U. and Brown, S., (1994). Towards high resolution maps of the mouse and human genomes?a facility for ordering markers to 0.1 cM resolution. Human Molecular Genetics. 3 (4)

Hoheisel, J., (1993). High resolution cosmid and P1 maps spanning the 14 Mb genome of the fission yeast S. pombe. Cell. 73 (1)

Schalkwyk, LC., Charlebois, RL. and Doolittle, WF., (1993). Insertion sequences on plasmid pHV1 of Haloferax volcanii. Canadian Journal of Microbiology. 39 (2)

Schalkwyk, LC., (1993). Halobacterial genes and genomes. New Comprehensive Biochemistry. 26 (C)

Cohen, A., Lam, WL., Charlebois, RL., Doolittle, WF. and Schalkwyk, LC., (1992). Localizing genes on the map of the genome of Haloferax volcanii, one of the Archaea.. Proceedings of the National Academy of Sciences. 89 (5)

Doolittle, WF., Lam, WL., Schalkwyk, LC., Charlebois, RL., Cline, SW. and Cohen, A., (1992). Progress in developing the genetics of the halobacteria.. Biochemical Society Symposia. 58 (58)

Charlebois, RL., Schalkwyk, LC., Hofman, JD. and Doolittle, W., (1991). Detailed physical map and set of overlapping clones covering the genome of the archaebacterium Haloferax volcanii DS2. Journal of Molecular Biology. 222 (3)

Charlebois, RL., Hofman, JD., Schalkwyk, LC., Lam, WL. and Doolittle, WF., (1989). Genome mapping in halobacteria. Canadian Journal of Microbiology. 35 (1)

Cline, SW., Schalkwyk, LC. and Doolittle, WF., (1989). Transformation of the archaebacterium Halobacterium volcanii with genomic DNA.. Journal of Bacteriology. 171 (9)

Cline, SW., Lam, WL., Charlebois, RL., Schalkwyk, LC. and Doolittle, WF., (1989). Transformation methods for halophilic archaebacteria. Canadian Journal of Microbiology. 35 (1)

Hofman, JD., Schalkwyk, LC. and Doolittle, WF., (1986). ISH51: a large, degenerate family of insertion sequence-like elements in the genome of the archaehacterium, Halobacterium volcanii. Nucleic Acids Research. 14 (17)

Chapters (1)

Nock, C., Gauss, C., Schalkwyk, LC., Klose, J., Lehrach, H. and Himmelbauer, H., (2007). Technology development at the interface of proteome research and genomics: Mapping nonpolymorphic proteins on the physical map of mouse chromosomes. In: From Genome to Proteome: Advances in the Practice & Application of Proteomics. 447- 452. 9783527613489

Conferences (32)

Spiers, H., Bray, N., Hannon, E., Schalkwyk, L., Wong, C., Pidsley, R., Smith, R. and Mill, J., (2015). Dynamic and sex-specific changes in DNA methylation during human fetal brain development

Boks, MPM., van Mierlo, H., Rutten, BPF., Radstake, TRDJ., De Witte, LD., Geuze, E., Horvath, S., Schalkwyk, LC., Vinkers, CH., Broen, JCA. and Vermetten, E., (2015). Longitudinal Changes of Telomere Length and Epigenetic Age Related to Traumatic Stress and Post-traumatic Stress Disorder

Rutten, B., Vermetten, E., Vinkers, C., Pishva, E., Kenis, G., de Nijs, L., Eijssen, L., Viechtbauer, W., van den Hove, D., Schraut, K., Lesch, K-P., Daskalakis, N., Yehuda, R., Schalkwyk, L., Lunnon, K., Mill, J., Nievergelt, C., Baker, DS., Geuze, E. and Boks, MPM., (2015). Blood-based DNA Methylation Signatures of Susceptibility to Traumatic Stress; Results From A Dutch Prospective Military Cohort Study

Powell, TR., Schalkwyk, LC., Breen, G., Lawrence, T., Pariante, C., McGuffin, P., Tansey, K., Uher, R. and D'Souza, UM., (2012). Identifying transcriptomic biomarkers for response to escitalopram in the inflammatory cytokine pathway

Kõks, S., Velthut, A., Sarapik, A., Altmäe, S., Reinmaa, E., Schalkwyk, LC., Fernandes, C., Lad, H., Soomets, U., Jaakma, Ü. and Salumets, A., (2011). 166 THE DIFFERENTIAL TRANSCRIPTOME AND ONTOLOGY PROFILES OF MURAL AND CUMULUS GRANULOSA CELLS IN STIMULATED HUMAN ANTRAL FOLLICLES

Sikk, K., Koks, S., Soomets, U., Schalkwyk, LC., Fernandes, C., Haldre, S., Aquilonius, S-M. and Taba, P., (2010). Peripheral blood RNA gene expression profiling in illicit methcathinone users reveals effect on immune system

Amos-Landgraf, J. and Schalkwyk, LC., (2008). The 21st International Mammalian Genome Conference Meeting Report

Meaburn, E., Harlaar, N., Craig, IW., Schalkwyk, LC. and Plomin, R., (2007). Genomewide gene expression profiles as a biological basis for non-shared environment: MZ twins discordant for reading ability

Paya-Cano, J., Sluyter, F., Mineur, Y., Fernandes, C., Crusio, W. and Schalkwyk, L., (2006). P.1.a.015 Strain differences in susceptibility to unpredictable chronic mild stress as assessed by hippocampal gene expression profiling

Binder, E., Paya-Cano, J., Sluyter, F. and Schalkwyk, L., (2006). P.1.d.016 The effects of a selective serotonin reuptake inhibitor and a tricyclic antidepressant on the behaviour of chronically stressed 129SvemJ and C57BL/6J mice in the hole board and forced swim test

Meaburn, E., Butcher, LM., Harlaar, N., Curtis, C., Craig, IW., Schalkwyk, LC. and Plomin, R., (2006). An association scan using pooled DNA and 100k SNPS identifies a 'SNP set' for early reading

Huezo-Diaz, P., Williamson, R., Nash, MW., Sim, SC., Alhberg, S., Hoda, F., Rietschel, M., Schmal, C., Farmer, A., Schulze, T., Hauser, J., Henigsberg, N., Maier, W., Zobel, A., Larsen, ER., Mors, O., Mendelewicz, J., Marusic, A., Perez, J., Schalkwyk, L., McGuffin, P., Craig, I., Ingelman-Sundberg, M. and Aitchison, KJ., (2006). CYP2D6 and CYP2C19 association data from GENDEP, a multicentre European study

Liu, L., Fernandes, C., Brookes, K., Paya-Capo, J., Asherson, P. and Schalkwyk, L., (2005). P.2.07 Selecting over-active extremes in outbred heterogeneous stock (HS) mice for gene expression profiling: nominating novel candidate genes for over-activity

Meaburn, EL., Butcher, LM., Knight, J., Craig, I., Schalkwyk, LC. and Plomin, R., (2005). QTLs for reading disability at 7 years: Genotyping pooled DNA on 100K SNP microarrays

Butcher, LM., Meaburn, E., Knight, J., Sham, PC., Schalkwyk, LC., Craig, IW. and Plomin, R., (2005). SNPs, microarrays, and pooled DNA: Identification of four loci associated with mild mental impairment in a sample of 6000 children

Butcher, LM., Meaburn, E., Knight, J., Sham, PC., Schalkwyk, LC., Craig, IW. and Plomin, R., (2005). Allelotyping over 10,000 SNPs using DNA pools and microarrays nominates four SNPs associated with mild mental impairment

Sugden, K., D'Souza, UM., McGuffin, P., Schalkwyk, LC., Aitchison, KJ. and Pariante, CM., (2005). Gene expression analyses of a mouse fibroblast cell line after antidepressant treatment

Butcher, LM., Meaburn, E., Dale, PS., Sham, P., Schalkwyk, L. and Plomin, R., (2004). Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single nucleotide polymorphisms

Fernandes, C., Liu, L., Paya-Cano, JL., Whatley, SA. and Schalkwyk, LC., (2004). Correlating behaviour with gene expression: Identifying genes for anxiety and cognition in the mouse.

Meaburn, EL., Butcher, ML., Liu, L., Fernandes, C., Sham, P., Plomin, R., Craig, I. and Schalkwyk, L., (2004). DNA pools on 10K genechips: Solving the QTL problem of large samples and large numbers of SNPS

Fernandes, C., Paya-Cano, J., Sluyter, F., D'Souza, U., Plomin, R. and Schalkwyk, LC., (2003). The power of gene expression profiling and mouse models to unravel behavior.

Sluyter, F. and Schalkwyk, LC., (2003). Symposium: Using microarrays in the analysis of behavior

Chamberlain, S., Bizarro, L., Fernandes, C., Schalkwyk, L. and Stolerman, IP., (2003). Nicotinic receptors containing the alpha7 subunit do not contribute to nicotine discrimination

Meaburn, E., Schalkwyk, L., Criag, I. and Plomin, R., (2003). A genome wide scan using 400 non-synonymous SNP markers in DNA pools identifies genes associated with language impairment in children

Galsworthy, MJ., Paya-Cano, JL., Liu, L., Fernandes, C., Schalkwyk, L. and Plomin, R., (2002). The reliabilities, interrelationships and quantitative genetics of cognitive tasks in mus musculus: A study of 250 heterogeneous stock mice

Meaburn, EK., Butcher, LM., Schalkwyk, L., Craig, I. and Plomin, R., (2002). Localisation of quantitative trait loci responsible for the heritability of language impairment using DNA pooling

Hill, L., Meaburn, E., Butcher, LM., Schalkwyk, L., Craig, IW. and Plomin, R., (2002). A genome scan using non-synonymous SNPs in coding regions and general cognitive ability

Tandon, K., Schalkwyk, L., Patel, M., Kinirons, M., Kerwin, R., McGuffin, P. and Aitchison, KJ., (2002). An amino acid substitution (IIe109Val) in CYP2D6

Meaburn, EL., Plomin, R. and Schalkwyk, L., (2001). Single nucleotide polymorphism genotyping in DNA pools.

Vettakkorumakankav, NN., Stevenson, KJ., Schalkwyk, LC. and Doolittle, WF., (1994). Disruption of the gene coding for dihydrolipoamide dehydrogenase in Haloferax volcanii by homologous recombination.

ROSS, MT., KNIGHTS, CJ., ROEST CROLLIUS, H., LABELLA, T., HOLLOWAY, E., MIFSUD, J., LI, K., LAM, V., VATCHEVA, R., KUMLEIN, J., FRANCIS, F., MOTT, R., SCHALKWYK, L., BHOGAL, R., ZEHETNER, G. and LEHRACH, H., (1993). BUILDING AN INTEGRATED PHYSICAL AND GENETIC-MAP OF THE HUMAN X-CHROMOSOME

DOOLITTLE, WF., CHARLEBOIS, RL., SCHALKWYK, LC., LAM, WL., CONOVER, RK., TSOULUHAS, D., CLINE, SW., HOFMAN, JD. and COHEN, A., (1991). PHYSICAL MAPPING AND GENE-TRANSFER METHODS FOR HALOBACTERIUM (HALOFERAX) VOLCANII

Other (8)

Wong, CCY., Parikshak, N., Spiers, H., Brays, NJ., Lysenko, L., Troakes, C., Viana, J., Hannon, E., Schalkwyk, L., Geschwind, D. and Mill, J., (2017).METHYLOMIC ANALYSIS OF AUTISM BRAIN: DISEASE ASSOCIATED VARIATION AND SUPPORT FOR A NEURODEVELOPMENTAL COMPONENT TO ETIOLOGY. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Viana, J., Pidsley, R., Hannon, E., Spiers, H., Troakes, C., Al-Saraj, S., Mechawar, N., Turecki, G., Schalkwyk, L., Bray, NJ. and Mill, J., (2017).INVESTIGATING EPIGENOMIC REGULATION IN SCHIZOPHRENIA. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Spiers, H., Hannon, E., Schalkwyk, L., Bray, N. and Mill, J., (2017).DNA HYDROXYMETHYLATION ASSOCIATED WITH HUMAN FETAL BRAIN DEVELOPMENT. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Hannon, E., Lunnon, K., Schalkwyk, L. and Mill, J., (2017).CHARACTERIZING INTER-INDIVIDUAL VARIATION IN DNA METHYLATION BETWEEN BLOOD AND BRAIN: IMPLICATIONS FOR EPIGENETIC STUDIES OF PSYCHIATRIC PHENOTYPES. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Hannon, E., Dempster, E., Burrage, J., Smith, A., Gurling, H., Basso, N., McQuillin, A., Schalkwyk, L. and Mill, J., (2017).AN INTEGRATED GENETIC-EPIGENETIC ANALYSIS OF SCHIZOPHRENIA. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Hannon, E., Spiers, H., Viana, J., Pidsley, R., Burrage, J., Murphy, T., Troakes, C., Turecki, G., O'Donovan, M., Schalkwyk, L., Bray, NJ. and Mill, J., (2017).METHYLATION QUANTITATIVE TRAIT LOCI (MQTL) IN THE DEVELOPING HUMAN BRAIN AND THEIR ENRICHMENT IN GENOMIC REGIONS ASSOCIATED WITH SCHIZOPHRENIA. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Dempster, E., Hannon, E., Schalkwyk, L., Bohlken, M., Kaprio, J., Toulopoulou, T., Spector, T., Hulshoffpol, H., Nenadic, I., Cannon, T., Hultman, C., Murray, R. and Mill, J., (2017).GENOME-WIDE METHYLOMIC ANALYSIS OF MONOZYGOTIC TWINS DISCORDANT FOR SCHIZOPHRENIA. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Xia, B., Kepa, A., Colvert, E., Mea-burn, E., Ronald, A., Schalkwyk, L., Mill, J., Plomin, R., Happe, F. and Wong, CCY., (2017).AN INVESTIGATION OF X-CHROMOSOME INACTIVATION PROFILES USING A GENETICALLY SENSITIVE DISCORDANT TWIN DESIGN. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Grants and funding

2017

Regulatory genomic profiling in schizophrenia

Medical Research Council

2014

Methylomic Profiling in Schizophrenia: Towards an Integrated Genetic-Epigenetic Approach

Medical Research Council

Contact

lschal@essex.ac.uk
+44 (0) 1206 873322

Location:

3SW.6.16, Colchester Campus