BS281-5-AU-CO:
Protein Bioinformatics
2020/21
Life Sciences (School of)
Colchester Campus
Autumn
Undergraduate: Level 5
ReassessmentOnly
Thursday 08 October 2020
Friday 18 December 2020
15
30 July 2020
Requisites for this module
BS131
(none)
(none)
(none)
(none)
The post-genome era has seen significant advances in our ability to obtain biological data, be it protein sequences or structures. Bioinformatics have become an indispensible skill for the next generation of biochemists and biologists in order to retrieve, analyse and interpret data.
This module will focus on how to decode the role and the molecular evolution of a protein starting from its sequence. The lectures will teach the theory and the computer practicals will introduce some of the many computer and web resources available to perform bioinformatics analyses.
This module will introduce the different resources and tools available on-line for the study of protein structure and interaction.
On successful completion of this module, students will be able to:
1. use and retrieve information from protein databases and protein portals;
2. align protein sequences, and edit them in the light of amino acid similarities;
3. predict protein secondary and tertiary structure and protein-protein interaction;
4. observe and modify protein structure files using PyMol;
5. use webtools to recognise motifs in a protein sequence;
6. define the principles of molecular dynamics and perform energy minimisation.
No additional information available.
8 x 1 hour lectures plus 1 revision class; 7 x 2 hour workshops
- Crosara, Karla Tonelli Bicalho; Moffa, Eduardo Buozi; Xiao, Yizhi; Siqueira, Walter Luiz. (2018-01) 'Merging in - silico and in vitro salivary protein complex partners using the STRING database: A tutorial', in Journal of Proteomics. vol. 171, pp.87-94
- Prischi, Filippo; Konarev, Petr V.; Iannuzzi, Clara; Pastore, Chiara; Adinolfi, Salvatore; Martin, Stephen R.; Svergun, Dmitri I.; Pastore, Annalisa. (2010-12) 'Structural bases for the interaction of frataxin with the central components of iron–sulphur cluster assembly', in Nature Communications. vol. 1 (1)
- Brooke, Greg N.; Prischi, Filippo. (2020-12) 'Structural and functional modelling of SARS-CoV-2 entry in animal models', in Scientific Reports. vol. 10 (1)
The above list is indicative of the essential reading for the course. The library makes provision for all reading list items, with digital provision where possible, and these resources are shared between students. Further reading can be obtained from this module's reading list.
Assessment items, weightings and deadlines
| Coursework / exam |
Description |
Deadline |
Coursework weighting |
| Coursework |
Moodle Quiz |
|
30% |
| Coursework |
Worksheet |
|
30% |
| Practical |
Problem Solving Activity |
|
40% |
Exam format definitions
- Remote, open book: Your exam will take place remotely via an online learning platform. You may refer to any physical or electronic materials during the exam.
- In-person, open book: Your exam will take place on campus under invigilation. You may refer to any physical materials such as paper study notes or a textbook during the exam. Electronic devices may not be used in the exam.
- In-person, open book (restricted): The exam will take place on campus under invigilation. You may refer only to specific physical materials such as a named textbook during the exam. Permitted materials will be specified by your department. Electronic devices may not be used in the exam.
- In-person, closed book: The exam will take place on campus under invigilation. You may not refer to any physical materials or electronic devices during the exam. There may be times when a paper dictionary,
for example, may be permitted in an otherwise closed book exam. Any exceptions will be specified by your department.
Your department will provide further guidance before your exams.
Overall assessment
Reassessment
Module supervisor and teaching staff
Dr Filippo Prischi, email: fprischi@essex.ac.uk.
Dr Filippo Prischi
School Undergraduate Office, email: bsugoffice (Non essex users should add @essex.ac.uk to create the full email address)
No
No
No
Dr Thomas Clarke
University of East Anglia
Senior lecturer/associate professor
Available via Moodle
Of 31 hours, 27 (87.1%) hours available to students:
4 hours not recorded due to service coverage or fault;
0 hours not recorded due to opt-out by lecturer(s).
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