Academic Staff

I am interested in applying mathematics and statistics towards all areas of biomedical research. My research efforts are concentrated on the analysis of data-rich functional genomics experiments. These include microarrays and proteomics, and I collaborate with a number of biologists and medics.

Linked with the Department of Biological Sciences.

• Bioinformatics

Memon, F. N., Owen, A. M., Sanchez-Graillet, O., Upton, G. J. G. and Harrison, A. P. (2010) Identifying the impact of G-Quadruplexes on Affymetrix 3' Arrays using Cloud Computing. Journal of Integrative Bioinformatics, 7(2):111, 2010. Online Journal: http://journal.imbio.de/index.php?paper id=111

Upton G., Sanchez-Graillet O., Rowsell J., Graham N., Arteaga-Salas J., Stalteri M., Memon F., May S. and Harrison A. “On the causes of outliers in Affymetrix GeneChip data”, Briefings in Functional Genomics and Proteomics, 8, 199

Langdon W., Upton G. and Harrison A. 2009, “Probes containing runs of guanines provide insights into the biophysics and bioinformatics of Affymetrix GeneChips”, Briefings in Bioinformatics, 10, 259-277

Langdon W. and Harrison A. 2009, “Evolving DNA motifs to predict GeneChip probe performance”, Algorithms for Molecular Biology, 4, 6

Chen M. and Harrison A. 2008, “In-silico analysis of crop science: Report on the first China-UK workshop on Chips, computers and crops”, Genomics, Proteomics and Bioinformatics, 6, 190-198

Upton G., Langdon W. and Harrison A. 2008, “G-spots cause incorrect expression measurements in Affymetrix microarrays”, BMC Genomics, 9, 613

Langdon W., Upton G., da Silva Camargo R. and Harrison A. 2008, “A survey of spatial defects in Homo Sapiens Affymetrix GeneChips”, IEEE/ACM Transactions on Computational Biology and Bioinformatics, 9, 5555

Arteaga-Salas J., Harrison A. and Upton G., 2008, “Reducing spatial flaws in oligonucleotide arrays by using neighbourhood informations”, Statistical Applications in Genetics and Molecular Biology, 7, 29

Sanchez-Graillet O., Rowsell J., Langdon W., Stalteri M., Arteaga-Salas J., Upton G. and Harrison A., 2008, “Widespread existence of uncorrelated probe intensities from within the same probeset on Affymetrix GeneChips”, Journal of Integrative Bioinformatics, 5, 98

Langdon W. and Harrison A., 2008, “Genetic Programming on parallel Graphics Hardware for mega Bioinformatics Data Mining”, Soft Computing, 12, 1169-1183

Arteaga-Salas J., Zuzan H., Langdon W., Upton G. and Harrison A., 2008, “An overview of image processing methods for Affymetrix GeneChips”, Briefings in Bioinformatics, 9, 25-33

Harrison A., Johnston C. and Orengo C., 2007, “Establishing a major cause of discrepancy in the calibration of Affymetrix GeneChips”, BMC Bioinformatics, 8, 195

Redfern O., Harrison A., Dallman T., Pearl F. and Orengo C., 2007, “CATHEDRAL: Assigning folds and domain boundaries to multi-domain protein structures”, PLoS Computational Biology, 3, e323

Stalteri M. and Harrison A., Interpretation of multiple probe sets mapping to the same gene in Affymetrix GeneChips. BMC Bioinformatics. 2007 Jan 15;8(1):13

Stalteri M. and Harrison A., Comparisons of annotation predictions for affymetrix GeneChips. Appl Bioinformatics. 2006;5(4):237-48.

Myers RE, Gale CV, Harrison A, Takeuchi Y, Kellam P., A statistical model for HIV-1 sequence classification using the subtype analyser (STAR). Bioinformatics. 2005 Sep 1;21(17):3535-40

Pearl F, Todd A, Sillitoe I, Dibley M, Redfern O, Lewis T, Bennett C, Marsden R, Grant A, Lee D, Akpor A, Maibaum M, Harrison A, Dallman T, Reeves G, Diboun I, Addou S, Lise S, Johnston C, Sillero A, Thornton J, Orengo C., The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D247-51.

Harrison A. and Orengo C., 2004, 10 entries in "Dictionary of Bioinformatics and Computational Biology", ed. Zvelebil M. and Hancock J., Wiley

Harrison A., Pearl F., Sillitoe I., Slidel T., Mott R., Thornton J. & Orengo C. 2003, "Recognising the fold of a protein", Bioinformatics, 19(14), 1748-1759

Pearl F., Bennett C., Bray J., Harrison A., Martin N., Shepherd A., Sillitoe I., Thornton J., Orengo C. 2003, "The CATH database: an extended protein family resouce for structural and functional genomics", Nucleic Acids Research, 31(1), 452

Harrison A., Pearl F., Mott R., Thornton J. & Orengo C. 2002, "Quantifying the similarities within fold space", 2002, Journal of Molecular Biology, 323(5), 909

Orengo C., Bray J., Buchan D., Harrison A., Lee D., Pearl F., Sillitoe I., Todd A. & Thornton J. 2002, "The CATH protein family database: A resource for structural and functional annotation of genomes", Proteomics, 2, 11

Wiedner M., Wilson C., Harrison A., Hills R., Lay O. & Carlstrom J. 2002, "Interferometric observations of the nuclear region of Arp 220 at Submillimeter Wavelengths", Astrophysical Journal, 581, 229

Pearl F., Martin N., Bray J., Buchan D., Harrison A., Lee D., Reeves G., Shepherd A., Sillitoe I., Todd A., Thornton J., & Orengo C. 2001, "A rapid classification for the CATH domain database to support Structural Genomics", Nucleic Acids Research 29, 223I

Pearl F., Lee D., Bray J., Sillitoe I, Todd A., Harrison A., Thornton J. & Orengo C. 2000, "Assigning genomic sequences to CATH", Nucleic Acids Research 28, 277

Harrison A., Henkel C. & Russell A. 1999, "Carbon Monoxide in the centre of NGC 253 revisited", Monthly Notices of the Royal Astronomical Society, 303, 157

Harrison A., Puxley P., Russell A. & Brand P. 1998, "The ortho- to para- ratio of H2 in the starburst of NGC 253", Monthly Notices of the Royal Astronomical Society, 297, 624

Ivison R. & Harrison A. & Coulson I. 1998, "No C+ emission from the z=3.317 damped Lyman-alpha absorbed towards PC1643+4631A", Astronomy & Astrophysics, 330, 443

Ivison R. & Harrison A. 1996, "A search for N+ at z=3.8", Astronomy & Astrophysics, 309, 416

Harrison A., Puxley P., Russell A. & Brand P. 1995, "Atomic carbon and carbon monoxide in the nuclear region of NGC 253", Monthly Notices of the Royal Astronomical Society, 277, 413