2020 applicants

Dr Nicos Angelopoulos

School of Computer Science and Electronic Engineering (CSEE)
Dr Nicos Angelopoulos
  • Email

  • Telephone

    +44 (0) 1206 872898

  • Location

    5A.525, Colchester Campus

  • Academic support hours

    Wednesdays 12:00-13:00 & Fridays 11:00-12:00, or by appointment



I work on explainable, model based AI with application in bio-medicine and emphasis on backing ideas with open source code. My research interests lie in three broad categories: probabilistic logic programming specially for Bayesian machine learning logic programming for biological big data analytics Bayesian networks for the elucidation of genomic landscapes in cancer


  • BSc in Computer Science and Statistics University of Keele, (1992)

  • MSc in Advanced Computer Science (AI) Imperial College London, (1993)

  • PhD in Computer Science City, University London, (2001)

Research and professional activities

Research interests

probabilistic logic programming specially for Bayesian Machine Learning

Open to supervise

logic programming for biological big data analytics

Open to supervise

Bayesian networks for the elucidattion of genomic landscapes in cancer

Open to supervise

logic programming

Open to supervise

Conferences and presentations

Logic Programming for Big Data in Computational Biology

Invited presentation, Keynote presentation, 10th South of England Regional Programming Language Seminar (S-REPLS 10), London, United Kingdom, 18/9/2018

Bayesian inference over model structure

Invited presentation, Keynote presentation, Probabilistic Logic Programming (PLP 2015), ICLP, Cork, Ireland, 31/8/2015

Teaching and supervision

Current teaching responsibilities

  • Databases and Information Retrieval (CE205)


Journal articles (20)

Draaisma, K., Chatzipli, A., Taphoorn, M., Kerkhof, M., Weyerbrock, A., Sanson, M., Hoeben, A., Lukacova, S., Lombardi, G., Hanse, M., Fleischeuer, R., Leenstra, S., Watts, C., McAbee, J., Angelopoulos, N., Gorlia, T., Golfinopoulos, V., Kros, JM., Verhaak, RGW., van den Bent, MJ., McDermott, U., Robe, PA. and French, PJ., (2020). Molecular Evolution of IDH Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study. Journal of Clinical Oncology. 38 (1), 81-99

Jones, S., King, PJ., Antonescu, CN., Sugiyama, MG., Bhamra, A., Surinova, S., Angelopoulos, N., Kragh, M., Pedersen, MW., Hartley, JA., Futter, CE. and Hochhauser, D., (2020). Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation. Scientific Reports. 10 (1)

Rustad, EH., Yellapantula, V., Leongamornlert, D., Bolli, N., Ledergor, G., Nadeu, F., Angelopoulos, N., Dawson, KJ., Mitchell, TJ., Osborne, RJ., Ziccheddu, B., Carniti, C., Montefusco, V., Corradini, P., Anderson, KC., Moreau, P., Papaemmanuil, E., Alexandrov, LB., Puente, XS., Campo, E., Siebert, R., Avet-Loiseau, H., Landgren, O., Munshi, N., Campbell, PJ. and Maura, F., (2020). Timing the initiation of multiple myeloma. Nature Communications. 11 (1), 1917-

Maura, F., Bolli, N., Angelopoulos, N., Dawson, KJ., Leongamornlert, D., Martincorena, I., Mitchell, TJ., Fullam, A., Gonzalez, S., Szalat, R., Abascal, F., Rodriguez-Martin, B., Samur, MK., Glodzik, D., Roncador, M., Fulciniti, M., Tai, YT., Minvielle, S., Magrangeas, F., Moreau, P., Corradini, P., Anderson, KC., Tubio, JMC., Wedge, DC., Gerstung, M., Avet-Loiseau, H., Munshi, N. and Campbell, PJ., (2019). Genomic landscape and chronological reconstruction of driver events in multiple myeloma. Nature Communications. 10 (1), 3835-

Grinfeld, J., Nangalia, J., Baxter, J., Wedge, DC., Angelopoulos, N., Cantrill, R., Godfrey, AL., Papaemmanuil, E., Gundem, G., MacLean, C., Cook, J., Mudie, L., Meara, SO., Teague, JW., Butler, AP., Massie, CE., Williams, N., Nice, FL., Andersen, CL., Hasselbalch, HC., Guglielmelli, P., McMullin, MF., Vannucchi, AM., Harrison, CN., Gerstung, M., Green, AR. and Campbell, PJ., (2018). Classification and Personalized Prognosis in Myeloproliferative Neoplasms. The New England Journal of Medicine. 379 (15), 1416-1430

Mitchell, TJ., Turajlic, S., Rowan, A., Nicol, D., Farmery, JHR., Brien, TO., Martincorena, I., Tarpey, P., Angelopoulos, T., Yates, LR., Butler, AP., Raine, K., Stewart, GD., Challacombe, B., Fernando, A., Lopez, JI., Hazell, S., Chandra, A., Chowdhury, S., Rudman, S., Soultati, A., Stamp, G., Fotiadis, N., Pickering, L., Au, L., Spain, L., Lynch, J., Stares, M., Teague, J., Maura, F., Wedge, DC., Horswell, S., Chambers, T., Litchfield, K., Xu, H., Stewart, A., Elaidi, R., Oudard, S., McGranahan, N., Csabai, I., Gore, M., Futreal, PA., Larkin, J., Lynch, AG., Szallasi, Z., Swanton, C. and Campbell, PJ., (2018). Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal. Cell. 173 (3), 611-623

Angelopoulos, N. and Cussens, J., (2017). Distributional Logic Programming for Bayesian Knowledge Representation. International Journal of Approximate Reasoning. 80, 52-66

Maura, F., Petljak, M., Lionetti, M., Cifola, I., Liang, W., Pinatel, E., Alexandrov, L., Fullam, A., Martincorena, I., Dawson, K., Angelopoulos, T., Samur, M., Szalat, R., Zamora, J., Tarpey, P., Davies, H., Corradini, P., Anderson, K., Minvielle, S., Neri, A., Avet-Loiseau, H., Keats, J., Campbell, P., Munshi, N. and Bolli, N., (2017). Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines. Leukemia. 32 (4), 1043-1047

Angelopoulos, N., Stebbing, J., Xu, Y., Giamas, G. and Zhang, H., (2016). Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer. Data in Brief. 7, 740-746

Nunes, J., Zhang, H., Angelopoulos, N., Chetri, J., Osipo, C., Stebbing, J. and Giamas, G., (2016). ATG9A loss confers resistance to trastuzumab via c-Cbl mediated Her2 degradation. Oncotarget. 7 (19), 27599-27612

Angelopoulos, N., Abdallah, S. and Giamas, G., (2016). Advances in integrative statistics for logic programming. International Journal of Approximate Reasoning. 78, 103-115

Spanjaard, E., Smal, I., Angelopoulos, N., Verlaan, I., Matov, A., Meijering, E., Wessels, L., Bos, H. and Rooij, JD., (2015). Quantitative imaging of focal adhesion dynamics and their regulation by HGF and Rap1 signaling. Experimental Cell Research. 330 (2), 382-397

Zhang, H., Angelopoulos, N., Stebbing, J. and Giamas, G., (2015). Proteomic profile of KSR1-regulated signaling in response to genotoxic agents in breast cancer. Breast Cancer Research and Treatment. 151 (3), 555-568

Angelopoulos, N., (2015). Probabilistic Logic Programming (PLP’14). International Journal of Approximate Reasoning. 67, 59-59

Xu, Y., Zhang, H., Nguyen, VTTM., Angelopoulos, N., Nunes, J., Reid, A., Buluwela, L., Magnani, L., Stebbing, J. and Giamas, G., (2015). LMTK3 Represses Tumour Suppressor-Like Genes through Chromatin Remodeling in Breast Cancer. Cell Reports. 12 (5), 837-849

Stebbing, J., Zhang, H., Xu, Y., Arnhild, G., Paul, A., Angelopoulos, N. and Giamas, G., (2015). Characterization of the Tyrosine Kinase-Regulated Proteome in Breast Cancer by Combined use of RNA interference (RNAi) and Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) Quantitative Proteomics. Molecular and Cellular Proteomics. 14 (9), 2479-2492

MacIntyre, D., Chandiramani, M., Lee, YS., Kindinger, L., Smith, A., Angelopoulos, N., Lehne, BC., Arulkumaran, S., Brown, R., Teoh, TG., Holmes, E., Nicholson, JK., Marchesi, J. and Bennett, PR., (2015). The vaginal microbiome during pregnancy and the postpartum period in a European population. Scientific Reports. 5 (1)

Husi, H., McAllister, F., Angelopoulos, N., Butler, VJ., Bailey, KR., Malone, K., MacKay, L., Taylor, P., Page, AP., Turner, NJ., Barran, PE. and Walkinshaw, M., (2010). Selective Chemical Intervention in the Proteome ofCaenorhabditis elegans. Journal of Proteome Research. 9 (11), 6060-6070

Angelopoulos, N., Hadjiprocopis, A. and Walkinshaw, MD., (2009). Bayesian Model Averaging for Ligand Discovery. Journal of Chemical Information and Modeling. 49 (6), 1547-1557

Kemp, GJL., Angelopoulos, N. and Gray, PMD., (2002). Architecture of a mediator for a bioinformatics database federation. IEEE Transactions on Information Technology in Biomedicine. 6 (2), 116-122

Book chapters (1)

Angelopoulos, N., (2002). Probabilistic Finite Domains: A Brief Overview. In: Logic Programming. Springer Berlin Heidelberg. 475- 475. 9783540439301

Conferences (6)

Angelopoulos, N. and Wielemaker, J., (2019). Advances in Big Data Bio Analytics

Maura, F., Rustad, E., Yellapantula, V., Bolli, N., Leongamornlert, D., Nadeu, F., Angelopoulos, N., Dawson, K., Mitchell, T., Osborne, R., Ziccheddu, BZ., Carniti, C., Montefusco, V., Corradini, P., Anderson, KC., Moreau, P., Papaemmanuil, E., Alexandrov, L., Puente, X., Campo, E., Siebert, R., Avet-Loiseau, H., Munshi, N., Campbell, P. and Landgren, CO., (2019). Timing the initiation of multiple myeloma

Angelopoulos, N. and Wielemaker, J., (2017). Accessing biological data as Prolog facts

Angelopoulos, N. and Giamas, G., (2015). A logical approach to working with biological databases

Angelopoulos, N., Costa, VS., Azevedo, JA., Wielemaker, J., Camacho, R. and Wessels, L., (2013). Integrative functional statistics in logic programming

Canisius, S., Angelopoulos, N. and Wessels, L., (2013). ProSQLite: Prolog file based databases via an SQLite interface


+44 (0) 1206 872898


5A.525, Colchester Campus

Academic support hours:

Wednesdays 12:00-13:00 & Fridays 11:00-12:00, or by appointment

More about me
My personal web site.: http://stoics.org.uk/~nicos