People

Patricia Lopez

Senior Research Officer
School of Life Sciences
 Patricia Lopez
  • Email

  • Telephone

    +44 (0) 1206 873726

  • Location

    3SW.5.36, Colchester Campus

Research and professional activities

Current research

Systems analysis has identified points of limitation in the overall photosynthetic process. Some of these points are speculated to have resulted from rapid changes in environmental conditions like rising atmospheric CO2 and others to be evolutionary legacies. Currently my main focus is in this project is to aim to overcome these limitations by up-regulating the expression of specific protein and down-regulating the expression of others. To this end we are using Golden Gate technology to build multigene constructs that once stably transformed into the plant should alter the expression levels of our target genes generating phenotypes of increased photosynthesis and growth. Most of the work is currently based on tobacco, nevertheless; we are hoping to quickly move into species of agronomic interest like rice, cassava and soy bean.

Additionally, I have some lines of work looking at the importance of CP12 in higher plants and cyanobacteria.

Publications

Journal articles (8)

Lopez-Calcagno, PE., Fisk, S., Brown, KL., Bull, SE., South, PF. and Raines, CA., (2019). Overexpressing the H-protein of the glycine cleavage system increases biomass yield in glasshouse and field grown transgenic tobacco plants. Plant Biotechnology Journal. 17 (1), 141-151

Simkin, AJ., López-Calcagno, PE. and Raines, CA., (2019). Feeding the world: improving photosynthetic efficiency for sustainable crop production. Journal of Experimental Botany. 70 (4), 1119-1140

South, PF., Cavanagh, AP., Lopez-Calcagno, PE., Raines, CA. and Ort, DR., (2018). Optimizing photorespiration for improved crop productivity. Journal of Integrative Plant Biology. 60 (12), 1217-1230

Elena López-Calcagno, P., Omar Abuzaid, A., Lawson, T. and Anne Raines, C., (2017). Arabidopsis CP12 mutants have reduced levels of phosphoribulokinase and impaired function of the Calvin–Benson cycle. Journal of Experimental Botany. 68 (9), 2285-2298

Simkin, AJ., Lopez-Calcagno, PE., Davey, PA., Headland, LR., Lawson, T., Timm, S., Bauwe, H. and Raines, CA., (2017). Simultaneous stimulation of sedoheptulose 1,7‐bisphosphatase, fructose 1,6‐bisphophate aldolase and the photorespiratory glycine decarboxylase‐H protein increases CO2 assimilation, vegetative biomass and seed yield in Arabidopsis. Plant Biotechnology Journal. 15 (7), 805-816

Exposito-Rodriguez, M., Laissue, PP., López-Calcagno, PE., Mullineaux, PM., Raines, CA. and Simkin, AJ., (2017). Development of pGEMINI, a Plant Gateway Destination Vector Allowing the Simultaneous Integration of Two cDNA via a Single LR-Clonase Reaction. Plants. 6 (4), 55-55

López-Calcagno, PE., Howard, TP. and Raines, CA., (2014). The CP12 protein family: a thioredoxin-mediated metabolic switch?. Frontiers in Plant Science. 5 (JAN), 9-

López-Calcagno, PE., Moreno, J., Cedeño, L., Labrador, L., Concepción, JL. and Avilán, L., (2009). Cloning, expression and biochemical characterization of mitochondrial and cytosolic malate dehydrogenase from Phytophthora infestans. Mycological Research. 113 (6-7), 771-781

Contact

pelope@essex.ac.uk
+44 (0) 1206 873726

Location:

3SW.5.36, Colchester Campus