People

Megan Cowan

Postgraduate Research Student
School of Life Sciences
 Megan Cowan

Profile

Ask me about
  • Molecular Dynamics
  • Protein Crystallography
  • Protein Sequence Alignments and Homology Modelling
  • NanoBRET, BRET and FRET
  • Fluorescence and Bioluminescence

Biography

I did my undergraduate degree in Biochemistry at the University of Essex. I have 12 months experience within AstraZeneca working on the development of a NanoBRET and FRET for identification of inhibitors for a strain of lung cancer. These two assays were successfully and fully developed and were used in high throughput screening. My final year project involved creating 2 mutant variants of copper nitrite reductase. These 2 mutant proteins were expressed, purified, crystallised and their structures solved using x-ray crystallography. I am currently in the second year of my PhD (studying in Singapore) where I am using classical molecular dynamics simulations to visualise the motion of protein molecules in explicit water solvent to aid in structure based drug design for a protein involved in prostate cancer. Since proteins are naturally fluid and dynamic structures in vivo, these simulations allow you to take a static protein structure from the PDB and simulate its movements using computation. If you have any questions or would like to know more about anything I do or have done, just drop me an email! :)

Research and professional activities

Thesis

Development of a Novel Therapy for the Treatment of Castrate Resistant Prostate Cancer

Supervisor: Dr. Richard Strange, , Dr. Mike Hough, , Dr. Chandra Verma.

Contact

mcowana@essex.ac.uk

Location:

Colchester Campus

Working pattern:

I am currently in Singapore, so my work hours are from 12:00am-10:00am (GMT)