(i) Research papers (2005-2011)

Hesford, C. M., Laing, S., Cardinale, M. and Cooper, C.E. (2011) Asymmetry of quadriceps muscle oxygenation during elite short-track speed skating.  Med. Sci. Sports Exerc.  In press

Holladay, R.S., Mason, M.G., Nicholls, P. and Cooper, C.E. (2011) Nitrogen dioxide oxidizes mitochondrial cytochrome c Free Radic. Biol. Med. In press

Gao, L. Elwell, C. E., Kohl-Bareis, M., Gramer, M., Cooper, C. E., Leung, T. S. and Tachtsidis, I. (2011) Effects of Assuming Constant Optical Scattering on Haemoglobin Concentration Measurements Using NIRS during a Valsalva Manoeuvre. Adv. Exp. Med. Biol. 915, 15-20 

Gao, L. Elwell, C. E., Kohl-Bareis, M., Gramer, M., Cooper, C. E., Leung, T. S. and Tachtsidis, I. Effects of Assuming Constant Optical Scattering on Haemoglobin Concentration Measurements Using NIRS during a Valsalva Manoeuvre. Adv. Exp. Med. Biol. 915, 15-20 (2011).

Bischin, C., Deac, F., Silaghi-Dumitrescu, R., Worrall, J. A., Rajagopal, B. S., Damian, G. and Cooper, C. E. (2011) Ascorbate peroxidase activity of cytochrome c  Free Radic. Res. 45: 439-444

Binzoni, T., Cooper, C. E., Wittekind, A. L., Beneke, R., Elwell, C. E., Van De Ville, D., and Leung, T. S. (2010) A new method to measure local oxygen consumption in human skeletal muscle during dynamic exercise using near-infrared spectroscopy. Physiol. Meas. 31:1257-1269

Cooper, C. E., Penfold, S. M., Elwell, C. E. and Angus, C. (2010) Comparison of local adipose tissue content and SRS-derived NIRS muscle oxygenation measurements in 90 individuals. Adv. Exp. Med. Biol. 662, 177-181

Tachtsidis, I., Gao, L., Leung, T. S., Kohl-Bareis, M., Cooper, C. E. and Elwell, C. E. (2010) A hybrid multi-distance phase and broadband spatially resolved spectrometer and algorithm for resolving absolute concentrations of chromophores in the near-infrared light spectrum. Adv. Exp. Med. Biol. 662, 169-175

Banaji, M., Mallet, A., Elwell, C. E., Nicholls, P., Tachtsidis, I., Smith, M. and Cooper, C. E. (2010) Modelling of mitochondrial oxygen consumption and NIRS detection of cytochrome oxidase redox state. Adv. Exp. Med. Biol. 662, 285-291.

Leung, T. S., Wittekind, A., Binzoni, T., Beneke, R., Cooper, C. E., and Elwell, C. E. (2010) Muscle oxygen saturation measured using “Cyclic NIR Signals” during exercise, Adv. Exp. Med. Biol. 662, 183-190. 

 Mason, M. G., Nicholls, P. and Cooper, C. E. (2009) The steady state mechanism of cytochrome c oxidase: redox interactions between metal centres. Biochem. J. 422, 237-246

Mason, M. G., Shepherd, M., Nicholls, P., Dobbin, P. S., Dodsworth, K. S., Poole, R. K. and Cooper, C. E. (2009) Cytochrome bd confers nitric oxide resistance to E. coli. Nature Chem. Biol. 5, 94-96.

Gaucher-Di Stasio, C., Paternotte, E., Prin-Mathieu, C., Reeder, B. J., Gaël Poitevin, G., Labrude, P., Stoltz, J-F., Cooper, C. E., Menu, P. (2009) The importance of the effect of shear stress on endothelial cells in determining the performance of hemoglobin based oxygen carriers Biomaterials 30, 445-451

Cooper, C. E., Cope, M., Elwell, C. E. and Delpy, D. T. (2009) Bicuculline-induced seizures: a challenge for optical and biochemical modeling of the cytochrome oxidase CuA NIRS signal Adv Exp Med Biol 645, 129-134.

Cooper, C. E., Sharpe, M. A., Mason, M. G. and Nicholls, P. (2009) Steady state redox levels in cytochrome oxidase: relevance for in vivo near infrared spectroscopy (NIRS) Adv Exp Med Biol 645, 123-128.

Reeder, B. J., Grey, M., Silaghi-Dumitrescu, R. L., Svistunenko, D. A., Bulow, L., Cooper, C. E. and Wilson, M. T. (2008) Tyrosine residues as redox cofactors in human hemoglobin: Implications for engineering non toxic blood substitutes. J. Biol. Chem 283, 30780-30787

Banaji, M., Mallett, A., Elwell, C. E., Nicholls, P. and Cooper, C. E. (2008) A model of brain circulation and metabolism: NIRS signal changes during physiological challenges PLOS Computational Biology Volume 4, e1000212 (15 pages)

Cooper, C. E. , Silaghi-Dumitrescu, R. L., Rukengwa, M., Alayash, A. I., and Buehler, P. W. (2008) Peroxidase activity of hemoglobin towards ascorbate and urate: a synergistic protective strategy against toxicity of hemoglobin-based oxygen carriers (HBOC) Biochim. et Biophys. Acta 1784 1415-1420

Leung, T. S., Tachtsidis, I., Elwell, C. E., Tisdall, M., Pritchard, C., Smith, M. and Cooper, C. (2008) Investigating Cross-Talk in Cytochrome C Oxidase Concentration Quantification Using Near Infrared Spectroscopy in a Two-Layered Model in Biomedical Optics, OSA Technical Digest (CD) (Optical Society of America, 2008), paper BSuE77.

Cooper, C. E. Mason, M. G., Nicholls, P. (2008) A dynamic model of nitric oxide inhibition of mitochondrial cytochrome c oxidase, Biochim. et Biophys. Acta, 1777, 867-876

Pipirou, Z., Bottrill, A. R., Svistunenko, D. A., Efimov, I., Basran, J., Mistry, S. C., Cooper, C. E., and Raven, E. L. (2007) The reactivity of heme in biological systems: autocatalytic formation of both tyrosine-heme and tryptophan-heme covalent links in a single protein architecture. Biochemistry, 46, 13269-13278

Svistunenko, D.A., Reeder, B.J., Wankasi, M.M., Silaghi-Dumitrescu, R.L., Cooper, C.E., Rinaldo, S., Cutruzzola, F. and Wilson, M.T. (2007) Reaction of Aplysia limacina metmyoglobin with hydrogen peroxide Dalton Trans. 840-850

Silaghi-Dumitrescu, R., Reeder, B.J., Nicholls, P., Cooper, C.E. and Wilson, M.T. (2007) Ferryl haem protonation gates peroxidatic reactivity in globins. Biochem. J. 403, 391-395

Tachtsidis, I., Tisdall, M., Leung, T.S., Cooper, C.E., Delpy, D.T., Smith, M. and Elwell, C.E. (2007) Investigation of in-vivo measurement of cerebral cytochrome-c-oxidase redox changes using near-infrared spectroscopy in patients with orthostatic hypotension. Physiol. Meas. 28, 199-21

Vollaard, N. B., Cooper, C. E. and Shearman, J. P. (2006) Exercise-induced oxidative stress in overload training and tapering, Med. Sci. Sports Exerc. 38, 1335-41.

Dunne, J., Caron, A., Menu, P., Alayash, A. I., Buehler, P. W., Wilson, M. T., Silaghi-Dumitrescu, R., Faivre, B. and Cooper, C. E. (2006) Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo, Biochem J. 399, 513-524.

Svistunenko, D. A., Davies, N., Brealey, D., Singer, M. and Cooper, C. E. (2006) Mitochondrial dysfunction in patients with severe sepsis: an EPR interrogation of individual respiratory chain components, Biochim. Biophys. Acta. 1757, 262-272.

Mason, M. G., Nicholls, P., Wilson, M. T. and Cooper, C. E. (2006) Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidase, Proc. Natl. Acad. Sci. U S A. 103, 708-713.

Vollaard, N. B., Cooper, C. E. and Shearman, J. P. (2006) Exercise-induced oxidative stress in overload training and tapering, Med. Sci. Sports Exerc. 38, 1335-41.

Myers, D. E., Cooper, C. E., Beilman, G. J., Mowlem, J. D., Anderson, L. D., Seifert, R. P. and Ortner, J. P. (2006) A wide gap second derivative NIR spectroscopic method for measuring tissue hemoglobin oxygen saturation, Adv Exp Med Biol. 578, 217-222.

Cooper, C. E., Pryor, D., Hall, C. and Griffin, M. (2006) NIRS-detected changes in the motor cortex during mental rehearsal of physical activity (imaginary exercise), Adv Exp Med Biol. 578, 185-190.

Cooper, C. E., Blannin, M., Hall, C. and Griffin, M. (2006) NIRS-detected changes in the arm during mental rehearsal of physical activity (imaginary exercise), Adv Exp Med Biol. 578, 191-196.

Griffin, M., Prior, D., Cooper, C. E., Wilkins, A. J. and Elwell, C. E. (2006) Near infrared spectroscopy as a noninvasive assessment of cortical abnormality in migraine?, Adv Exp Med Biol. 578, 203-208.

Davies, N.A., Brealey, D.A., Stidwill, R., Singer, M., Svistunenko, D.A. and Cooper, C.E. (2005) Nitrosyl heme production compared in endotoxemic and hemorraghic shock. Free Rad. Biol. Med. 38, 41-49.

Silkstone, G.G., Cooper, C.E. Svistunenko, D.A. and Wilson, M.T. (2005) EPR and Optical Spectroscopic Studies of Met80X Mutants of Yeast Ferricytochrome c. Models for Intermediates in the Alkaline Transition. J. Amer. Chem. Soc. 127, 92-99.

Myers, D.E., Anderson, L.D., Seifert, R.P., Ortner, J.P., Cooper, C.E. , Beilman, G.J., and Mowlem, J.D. (2005) Noninvasive method for measuring local hemoglobin oxygen saturation in tissue using wide gap second derivative near-infrared spectroscopy. J. Biomed. Optics 10, 034017 (18 pages)

Silaghi-Dunitrescu, R. and Cooper, C.E. Transient species involved in catalytic dioxygen/peroxide activation by hemoproteins: possible involvement of protonated compound I species (2005) Dalton Trans. 21, 3477-3482.

Cooper, C.E., Jurd, M., Nicholls, P., Wankasi, M.M., Svistunenko, D.A., Reeder, B.J. and Wilson, M.T. (2005) On the formation, nature, stability and biological relevance of the primary reaction intermediates of myoglobins with hydrogen peroxide Dalton Trans. 21, 3483 – 3488.

Vollaard, N.B.J., Reeder, B.J., Shearman, J.P., Menu, P., Wilson, M.T. and Cooper, C.E. (2005) A new sensitive assay reveals that hemoglobin is oxidatively modified in vivo Free Rad. Biol. Med. 39, 1216-1228

(ii) Books edited  (2005-2011)

C. E. Cooper and R. Beneke, Drugs and Ergogenic Aids to Improve Sport Performance (2008) Essays in Biochemistry Volume 44,  Portland Press, London

(iii) Review articles (2005-2011)

Cooper, C.E. (2009) Radical producing and consuming reactions of hemoglobin: how can we limit toxicity Art. Organ 33, 110-114

C. E. and Brown, G. C. (2008) The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance. J. Bioenerg. Biomemb. 40, 533-539

Cooper, C. E., (2008) The biochemistry of drugs and doping methods used to enhance aerobic sport performance, Essays in Biochemistry 44, 63-83.

Cooper, C. E. (2008) Drugs and ergogenic aids to improve sport performance, Essays in Biochemistry 44, 1-10.

Mason, M.G., Holladay, R. S., Nicholls, Shepherd, M. and Cooper, C. E. (2008) A quantitative approach to nitric oxide inhibition of terminal oxidases of the respiratory chain, Methods in Enzymology 437, 135-159

Cooper, C. E and Giulivi, C., (2007) Nitric oxide regulation of mitochondrial oxygen consumption II: molecular mechanism and tissue physiology, Am. J. Physiol. Cell Physiol. 292, C1993-C2003.

Giulivi, C., Kato, K. and Cooper, C. E. (2006) Nitric oxide regulation of mitochondrial oxygen consumption I: cellular physiology, Am. J. Physiol. Cell Physiol. 291, C1225-C1231