Dr. Jody Mason

My main research aims are to develop new inhibitors to age-related diseases such as Alzheimer's and Parkinson's. The approach I'm taking involves using CANDI-PCA to both find and then select small peptides that bind amyloid.

Dr. Neil Kad

My group uses single molecule techniques to investigate how amyloid proteins form fibrils. In particular we are using TIRF imaging to follow the growth of amyloid. We have designed a unique flow-through system that plugs into our TIRFM to allow the exchange of solutions. This has allowed us to introduce inhibitors designed by Jody's group into our fibril growth assays and begin to understand how they work.

Dr. Philip Reeves

My lab focuses on characterisation of mutations located in the rhodopsin gene; these comprise the majority of mutations known to be associated with autosomal dominant retinitis pigmentosa (ADRP). Retinitis Pigmentosa (RP) is a group of inherited disorders that leads to degeneration of the retina and results in varying degrees of blindness. The precise mechanism of RP remains ill-defined and there is currently no cure. We are interested in understanding rhodopsin misfolding and aggregation so we can find new targets for therapeutic intervention to halt or slow down disease progression.